OPY2_YEAST - dbPTM
OPY2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPY2_YEAST
UniProt AC Q06810
Protein Name Protein OPY2
Gene Name OPY2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 360
Subcellular Localization Cell membrane
Single-pass membrane protein . Vacuole membrane
Single-pass membrane protein .
Protein Description Component of the high-osmolarity glycerol (HOG) pathway involved in mating response and osmotolerance. May act as a membrane anchor for the STE50/STE11 complex..
Protein Sequence MSSSSKASASSSLSSTATSSTSATRGSDGCVVCDSTASCPVCASGEYCVMTSLTCDKCPSTYCAKQSDSQLSSLSSSSSSSSSSNSNEKTSLIVGFTVGIVGGAMLIALVALYFINKRYWKPKRQKNKALKLEEASQSYGNEEEYFDDEDDDDEDDEDDGGMRKDESHTLFNTSLVPPTLNVPGNRSSASTTRTRASNILPIAYIPGVTSGLSTDKLQSKLRSSSKRQNAAGDIRSHITLGSSILDGLDDEDDEHNQVLNKDADDNLITAIRAKPKLVQIAEEESDKEIQDLDVIEEQTEADDLSHMAKSEASHGNNDEDDDEEGSFILDLEIPESIRESTQGSRTESPFEDKFEIHDER
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSSKASA
------CCCCCCCCC		38.6430377154
3Phosphorylation-----MSSSSKASAS
-----CCCCCCCCCC		37.0130377154
4Phosphorylation----MSSSSKASASS
----CCCCCCCCCCC		28.6630377154
8PhosphorylationMSSSSKASASSSLSS
CCCCCCCCCCCCCCC		32.2130377154
10PhosphorylationSSSKASASSSLSSTA
CCCCCCCCCCCCCCC		20.2630377154
11PhosphorylationSSKASASSSLSSTAT
CCCCCCCCCCCCCCC		34.7130377154
12PhosphorylationSKASASSSLSSTATS
CCCCCCCCCCCCCCC		29.7630377154
14PhosphorylationASASSSLSSTATSST
CCCCCCCCCCCCCCC		27.8230377154
19PhosphorylationSLSSTATSSTSATRG
CCCCCCCCCCCCCCC		29.2030377154
20PhosphorylationLSSTATSSTSATRGS
CCCCCCCCCCCCCCC		23.2530377154
136PhosphorylationALKLEEASQSYGNEE
CCHHHHHHHHHCCHH		23.9621551504
138PhosphorylationKLEEASQSYGNEEEY
HHHHHHHHHCCHHHH		32.2921551504
164UbiquitinationEDDGGMRKDESHTLF
CCCCCCCCCCCCCCC		57.8823749301
172N-linked_GlycosylationDESHTLFNTSLVPPT
CCCCCCCCCCCCCCC		31.69-
185N-linked_GlycosylationPTLNVPGNRSSASTT
CCCCCCCCCCCCCCC		34.29-
187PhosphorylationLNVPGNRSSASTTRT
CCCCCCCCCCCCCCC		33.9723749301
188PhosphorylationNVPGNRSSASTTRTR
CCCCCCCCCCCCCCC		24.0123749301
209PhosphorylationIAYIPGVTSGLSTDK
EEECCCCCCCCCHHH		24.0030377154
236PhosphorylationNAAGDIRSHITLGSS
HCCHHHHHHHHHCCH		21.4128889911
239PhosphorylationGDIRSHITLGSSILD
HHHHHHHHHCCHHHC		21.4628889911
242PhosphorylationRSHITLGSSILDGLD
HHHHHHCCHHHCCCC		19.8128889911
243PhosphorylationSHITLGSSILDGLDD
HHHHHCCHHHCCCCC		25.9328889911
285PhosphorylationVQIAEEESDKEIQDL
EEECCHHCCHHHCCH		58.2122369663
287UbiquitinationIAEEESDKEIQDLDV
ECCHHCCHHHCCHHH		67.0323749301
299PhosphorylationLDVIEEQTEADDLSH
HHHHHHHHHHHHHHH		36.1023749301
305PhosphorylationQTEADDLSHMAKSEA
HHHHHHHHHHHHHHH		20.4323749301
326PhosphorylationEDDDEEGSFILDLEI
CCCCCCCCEEEEEEC		16.6429650682
344PhosphorylationIRESTQGSRTESPFE
HHHHCCCCCCCCCCC		26.6419779198
346PhosphorylationESTQGSRTESPFEDK
HHCCCCCCCCCCCCC		42.3828889911
348PhosphorylationTQGSRTESPFEDKFE
CCCCCCCCCCCCCCC		33.9917330950
353UbiquitinationTESPFEDKFEIHDER
CCCCCCCCCCCCCCC		37.3923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPY2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPY2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPY2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSK1_YEASTSSK1genetic
16543225
STE50_YEASTSTE50physical
16543225
MNN11_YEASTMNN11genetic
17314980
MNN10_YEASTMNN10genetic
17314980
SSN8_YEASTSSN8genetic
17314980
UBP3_YEASTUBP3genetic
17314980
RMI1_YEASTRMI1genetic
17314980
ARO1_YEASTARO1genetic
17314980
EAF1_YEASTEAF1genetic
17314980
LSM7_YEASTLSM7genetic
17314980
ZRT1_YEASTZRT1genetic
17314980
SSN3_YEASTSSN3genetic
17314980
SLX5_YEASTSLX5genetic
17314980
SNF1_YEASTSNF1genetic
17314980
ACT_YEASTACT1genetic
17314980
RPB1_YEASTRPO21genetic
17314980
CTR9_YEASTCTR9genetic
17314980
BMH1_YEASTBMH1genetic
17314980
SAS3_YEASTSAS3genetic
17314980
IWR1_YEASTIWR1genetic
17314980
TRS85_YEASTTRS85genetic
17314980
GET3_YEASTGET3physical
18719252
STE50_YEASTSTE50physical
22904036
MTC1_YEASTMTC1physical
22904036
MIG1_YEASTMIG1physical
22904036
MIG2_YEASTMIG2physical
22904036
SSK1_YEASTSSK1genetic
23149115
COPA_YEASTCOP1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
STT3_YEASTSTT3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
ATU1_YEASTPCA1genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
CYK3_YEASTCYK3genetic
27708008
SWI5_YEASTSWI5genetic
27708008
MNN10_YEASTMNN10genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
SA190_YEASTSAP190genetic
27708008
PAM17_YEASTPAM17genetic
27708008
BPT1_YEASTBPT1genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
GAS1_YEASTGAS1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
MSB2_YEASTMSB2physical
26116211
SGTA_HUMANSGTAphysical
27107014
SWC5_YEASTSWC5genetic
29674565
SNT1_YEASTSNT1genetic
29674565
PP2C1_YEASTPTC1genetic
29674565
CYK3_YEASTCYK3genetic
29674565
SWI5_YEASTSWI5genetic
29674565
ERD1_YEASTERD1genetic
29674565
EMI1_YEASTEMI1genetic
29674565
CLG1_YEASTCLG1genetic
29674565
HOC1_YEASTHOC1genetic
29674565
CDC11_YEASTCDC11genetic
29674565
SA190_YEASTSAP190genetic
29674565
CDC73_YEASTCDC73genetic
29674565
POB3_YEASTPOB3genetic
29674565
MED4_YEASTMED4genetic
29674565
RUD3_YEASTRUD3genetic
29674565
AIM44_YEASTAIM44genetic
29674565
FUMH_YEASTFUM1genetic
29674565
LCB2_YEASTLCB2genetic
29674565
LCB1_YEASTLCB1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPY2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, AND MASSSPECTROMETRY.

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