ATU1_YEAST - dbPTM
ATU1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATU1_YEAST
UniProt AC P38360
Protein Name P-type cation-transporting ATPase
Gene Name PCA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1216
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions..
Protein Sequence MKPEKLFSGLGTSDGEYGVVNSENISIDAMQDNRGECHRRSIEMHANDNLGLVSQRDCTNRPKITPQECLSETEQICHHGENRTKAGLDVDDAETGGDHTNESRVDECCAEKVNDTETGLDVDSCCGDAQTGGDHTNESCVDGCCVRDSSVMVEEVTGSCEAVSSKEQLLTSFEVVPSKSEGLQSIHDIRETTRCNTNSNQHTGKGRLCIESSDSTLKKRSCKVSRQKIEVSSKPECCNISCVERIASRSCEKRTFKGSTNVGISGSSSTDSLSEKFFSEQYSRMYNRYSSILKNLGCICNYLRTLGKESCCLPKVRFCSGEGASKKTKYSYRNSSGCLTKKKTHGDKERLSNDNGHADFVCSKSCCTKMKDCAVTSTISGHSSSEISRIVSMEPIENHLNLEAGSTGTEHIVLSVSGMSCTGCESKLKKSFGALKCVHGLKTSLILSQAEFNLDLAQGSVKDVIKHLSKTTEFKYEQISNHGSTIDVVVPYAAKDFINEEWPQGVTELKIVERNIIRIYFDPKVIGARDLVNEGWSVPVSIAPFSCHPTIEVGRKHLVRVGCTTALSIILTIPILVMAWAPQLREKISTISASMVLATIIQFVIAGPFYLNALKSLIFSRLIEMDLLIVLSTSAAYIFSIVSFGYFVVGRPLSTEQFFETSSLLVTLIMVGRFVSELARHRAVKSISVRSLQASSAILVDKTGKETEINIRLLQYGDIFKVLPDSRIPTDGTVISGSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPKIQNIADKIASYFVPTIIGITVVTFCVWIAVGIRVEKQSRSDAVIQAIIYAITVLIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEGKLTVVHETVRGDRHNSQSLLLGLTEGIKHPVSMAIASYLKEKGVSAQNVSNTKAVTGKRVEGTSYSGLKLQGGNCRWLGHNNDPDVRKALEQGYSVFCFSVNGSVTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSEYIKDIVEGRNCDSSSQSKRPVVVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLNNILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFVDFHIPPEYAGLGELVSILPVIFVAILLRYAKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
255PhosphorylationSRSCEKRTFKGSTNV
HCCCCCCEECCCCCE		40.5427017623
259PhosphorylationEKRTFKGSTNVGISG
CCCEECCCCCEECCC		19.8727017623
274PhosphorylationSSSTDSLSEKFFSEQ
CCCCHHHHHHHHHHH		42.5727017623
294UbiquitinationNRYSSILKNLGCICN
HHHHHHHHHHHHHHH		48.7517644757
691PhosphorylationVKSISVRSLQASSAI
CCEEEHHHHHCCEEE		23.7628889911
695PhosphorylationSVRSLQASSAILVDK
EHHHHHCCEEEEECC		13.8227017623
769PhosphorylationVAGSVNGTGTLFVKL
EEEEECCCEEEEEEE		23.0727017623
771PhosphorylationGSVNGTGTLFVKLSK
EEECCCEEEEEEEEC		19.5027017623
787PhosphorylationPGNNTISTIATMVDE
CCCCCHHHHHHHHHH		15.6927017623
798PhosphorylationMVDEAKLTKPKIQNI
HHHHHHCCCHHHHHH		44.5927017623
964UbiquitinationAQNVSNTKAVTGKRV
CCCCCCCCCCCCCCC		45.1423749301
1048PhosphorylationGISLHILSGDDDGAV
CCEEEEECCCCCHHH		39.3028889911
1057PhosphorylationDDDGAVRSMAARLGI
CCCHHHHHHHHHHCC		13.2328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATU1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATU1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATU1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DOA10_YEASTSSM4physical
19515821
CTU1_YEASTNCS6genetic
20093466
PALF_YEASTRIM8genetic
20093466
RL24A_YEASTRPL24Agenetic
20093466
RS25A_YEASTRPS25Agenetic
20093466
TNA1_YEASTTNA1genetic
20093466
YO163_YEASTYOL163Wgenetic
20093466
AP2M_YEASTAPM4genetic
20093466
AUS1_YEASTAUS1genetic
20093466
BRR1_YEASTBRR1genetic
20093466
ACE2_YEASTACE2genetic
27708008
AUS1_YEASTAUS1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
FAB1_YEASTFAB1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
ATC1_YEASTPMR1genetic
27708008
FKS2_YEASTGSC2genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
THIK_YEASTPOT1genetic
27708008
VPS70_YEASTVPS70genetic
27708008
HMX1_YEASTHMX1genetic
27708008
RS25B_YEASTRPS25Bgenetic
27708008
PABC_YEASTABZ2genetic
27708008
AP2M_YEASTAPM4genetic
27708008
YO163_YEASTYOL163Wgenetic
27708008
BRR1_YEASTBRR1genetic
27708008
HSP71_YEASTSSA1physical
27059957
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATU1_YEAST

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Related Literatures of Post-Translational Modification

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