VPS70_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS70_YEAST
• UniProt AC: P47161
• Protein Name: Vacuolar protein sorting-associated protein 70
• Gene Name: VPS70
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 811
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Involved in vacuolar protein sorting..
• Protein Sequence: MRMIQRERKREKEEGQLKERTVVNMADPDDNEAEATGLQQYSGETTRDDNEESMNDSFTLTSRNRGRSNTISSIVSGYEIMKEHMDKEKFMYLILASLLLYMGFVAAFAPRTSLSRDFRRFHSSRLTNAEVYRIYLNSLQQENRAKEHVYKYAGYMSNGASDSSTFKYTLDEFLDMGYKPKVEKYYPWIGEPVDTNVAPLENGKVVYEASMIEDRVKGDPASHARKRQKGFHQYSKNGSVTARYVFCNYGSISDYKLLLKKNIDIEDKIHIVRSGKILPGLKVKNAELYGASSVIIYTDPFDDGKVTEENGFLHYPYGPARNPSYIRRDSVNYFSDTPGDPTTPGYPSKDSDTEHMSPVGRVPRIPSVPMSARDVQPILERLNGRGFQIGPGSNIKDFGSFTGPSSSIDKVHLHNELTYNIKEMSSVEVSIPGIFTEGEIIIGAHRDSLASSSAGDANSGSAILLEIARGMSKLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHAAILRRRALVYLNLDNAISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYTSNATISLLDGLSSYTSFQYHLGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNSDYKLHNTMAMFVGLTTLMLSENELARFNTHVYLKKIYNWYIAWHSNLSSAFPQDDEVNSLAKRVLDLLKVATQEDSIQFDQQNGILYKECREALPVWAFYKKIKSYIKLQRSNSKSKQIDQLFITHRGLKDREWMKYSLLAPSKFEGSVGEVLPGLHEGLADIDRNEVIQWLTILLSQFSNVRYLLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	N-linked_Glycosylation	DDNEESMNDSFTLTS CCCHHHCCCCEEEEE	51.56	-
78	Phosphorylation	ISSIVSGYEIMKEHM HHHHHHCHHHHHHHC	8.52	27017623
237	N-linked_Glycosylation	GFHQYSKNGSVTARY CCCCCCCCCCEEEEE	41.87	-
351	Phosphorylation	PGYPSKDSDTEHMSP CCCCCCCCCCCCCCC	50.60	28889911
353	Phosphorylation	YPSKDSDTEHMSPVG CCCCCCCCCCCCCCC	31.57	28889911
357	Phosphorylation	DSDTEHMSPVGRVPR CCCCCCCCCCCCCCC	20.52	28889911
533	Ubiquitination	SGTNFHCKANPLLQD CCCCCCCCCCHHHHH	42.50	17644757
547	Ubiquitination	DVIYEAAKLTEFNGH HHHHHHHHHHCCCCC	64.09	17644757
568	N-linked_Glycosylation	DHWKYTSNATISLLD CCCCCCCCCEEEHHH	33.05	-
599	N-linked_Glycosylation	AHFQFNANDTSGAVY EEEEEECCCCCCCEE	54.95	-
658	Ubiquitination	FNTHVYLKKIYNWYI CCCHHHHHHHHHHHH	21.31	17644757
659	Ubiquitination	NTHVYLKKIYNWYIA CCHHHHHHHHHHHHH	48.07	17644757
670	N-linked_Glycosylation	WYIAWHSNLSSAFPQ HHHHHHCCHHHCCCC	30.93	-
730	Phosphorylation	FYKKIKSYIKLQRSN HHHHHHHHHHHHHCC	9.32	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS70_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS70_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS70_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCM1_YEAST	HCM1	genetic	17314980
BFA1_YEAST	BFA1	genetic	17314980
PFD3_YEAST	PAC10	genetic	17314980
PFD2_YEAST	GIM4	genetic	17314980
MON1_YEAST	MON1	genetic	17314980
UME6_YEAST	UME6	genetic	17314980
TAF12_YEAST	TAF12	genetic	17314980
MAD2_YEAST	MAD2	genetic	17314980
SWR1_YEAST	SWR1	genetic	17314980
LSM1_YEAST	LSM1	genetic	17314980
XRN1_YEAST	XRN1	genetic	17314980
MET18_YEAST	MET18	genetic	17314980
SRB8_YEAST	SRB8	genetic	17314980
RT103_YEAST	RTT103	genetic	17314980
ELP2_YEAST	ELP2	genetic	17314980
SWD3_YEAST	SWD3	genetic	17314980
SSB1_YEAST	SSB1	physical	22940862
RL36A_YEAST	RPL36A	genetic	29158977

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.