| UniProt ID | SAS3_YEAST | |
|---|---|---|
| UniProt AC | P34218 | |
| Protein Name | Histone acetyltransferase SAS3 | |
| Gene Name | SAS3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 831 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. In vitro, SAS3 acetylates free histones H3 and H4. It is involved in silencing the HMR locus.. | |
| Protein Sequence | MSLTANDESPKPKKNALLKNLEIDDLIHSQFVRSDTNGHRTTRRLFNSDASISHRIRGSVRSDKGLNKIKKGLISQQSKLASENSSQNIVNRDNKMGAVSFPIIEPNIEVSEELKVRIKYDSIKFFNFERLISKSSVIAPLVNKNITSSGPLIGFQRRVNRLKQTWDLATENMEYPYSSDNTPFRDNDSWQWYVPYGGTIKKMKDFSTKRTLPTWEDKIKFLTFLENSKSATYINGNVSLCNHNETDQENEDRKKRKGKVPRIKNKVWFSQIEYIVLRNYEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKCLTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTLYYDVEPFIFYILTEREDTENHPYQNAAKFHFVGYFSKEKFNSNDYNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEKPLSDLGLLTYRTFWKIKCAEVLLKLRDSARRRSNNKNEDTFQQVSLNDIAKLTGMIPTDVVFGLEQLQVLYRHKTRSLSSLDDFNYIIKIDSWNRIENIYKTWSSKNYPRVKYDKLLWEPIILGPSFGINGMMNLEPTALADEALTNETMAPVISNNTHIENYNNSRAHNKRRRRRRRSSEHKTSKLHVNNIIEPEVPATDFFEDTVSSLTEYMCDYKNTNNDRLIYQAEKRVLESIHDRKGIPRSKFSTETHWELCFTIKNSETPLGNHAARRNDTGISSLEQDEVENDVDTELYVGENAKEDEDEDEDFTLDDDIEDEQISEENDEEEDTYEEDSDDDEDGKRKGQEQDENDIESHIRKERVRKRRKITLIEDDEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLTANDES ------CCCCCCCCC | 34.13 | 22369663 | |
| 4 | Phosphorylation | ----MSLTANDESPK ----CCCCCCCCCCC | 18.99 | 22369663 | |
| 9 | Phosphorylation | SLTANDESPKPKKNA CCCCCCCCCCCCCCC | 40.88 | 22369663 | |
| 79 | Acetylation | GLISQQSKLASENSS CHHHHHHHHHCCCCC | 43.67 | 22865919 | |
| 82 | Phosphorylation | SQQSKLASENSSQNI HHHHHHHCCCCCCCC | 47.98 | 27214570 | |
| 85 | Phosphorylation | SKLASENSSQNIVNR HHHHCCCCCCCCCCC | 29.29 | 27214570 | |
| 86 | Phosphorylation | KLASENSSQNIVNRD HHHCCCCCCCCCCCC | 38.54 | 27214570 | |
| 246 | Phosphorylation | SLCNHNETDQENEDR EECCCCCCCCCCHHH | 48.58 | 19779198 | |
| 367 | Acetylation | AKCFINSKTLYYDVE HHHHHCCCCCEEECC | 37.75 | - | |
| 532 | Phosphorylation | RHKTRSLSSLDDFNY HHCCCCCCCCCCCCE | 30.06 | 30377154 | |
| 533 | Phosphorylation | HKTRSLSSLDDFNYI HCCCCCCCCCCCCEE | 40.90 | 27214570 | |
| 684 | Acetylation | RLIYQAEKRVLESIH CCHHHHHHHHHHHHH | 51.31 | 25381059 | |
| 718 | Phosphorylation | FTIKNSETPLGNHAA EEECCCCCCCCCCHH | 24.51 | 23749301 | |
| 824 | Phosphorylation | VRKRRKITLIEDDEE HHHHCCCEEEECCCC | 25.39 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAS3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 367 | K | Acetylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAS3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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