NTO1_YEAST - dbPTM
NTO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NTO1_YEAST
UniProt AC Q12311
Protein Name NuA3 HAT complex component NTO1
Gene Name NTO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 748
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation..
Protein Sequence MNRGSLDDGPKLREEKHFQDFYPDLNADTLLPFIVPLVETKDNSTDTDSDDISNRNNREIGSVKSVQTKELIFKGRVTTEPLVLKKNEVEFQKCKITTNELKGKKNPYCVRFNESFISRYYHINKVRNRKSYKQQQKEFDGVEAPYFTKFSSKEAPNITISTSTKSAIQKFASISPNLVNFKPQYDMDEQDELYLHYLNKRYFKDQMSHEIFEILMTTLETEWFHIEKHIPSTNSLIARHNILRDCKNYELYGSDDGTGLSMDQACAVCLGTDSDNLNTIVFCDGCDIAVHQECYGIIFIPEGKWLCRRCMISKNNFATCLMCPSHTGAFKQTDTGSWVHNICALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCYICKKKMGACIQCFQRNCFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGINKARKYFSLLSTLQTETPQHNEANDRTNSKFNKTIWKTPNQTPVAPHVFAEILQKVVDFFGLANPPAGAFDICKYWSMKRELTGGTPLTACFENNSLGSLTEEQVQTRIDFANDQLEDLYRLKELTTLVKKRTQASNSLSRSRKKVFDIVKSPQKYLLKINVLDIFIKSEQFKALERLVTEPKLLVILEKCKHCDFDTVQIFKEEIMHFFEVLETLPGASRILQTVSSKAKEQVTNLIGLIEHVDIKKLLSRDFIINDDKIEERPWSGPVIMEEEGLSDAEELSAGEHRMLKLILNSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNRGSLDDGPKL
---CCCCCCCCCHHH		25.9530377154
44PhosphorylationLVETKDNSTDTDSDD
EEECCCCCCCCCCHH		37.4821551504
45PhosphorylationVETKDNSTDTDSDDI
EECCCCCCCCCCHHH		49.5320377248
47PhosphorylationTKDNSTDTDSDDISN
CCCCCCCCCCHHHCC		37.1720377248
49PhosphorylationDNSTDTDSDDISNRN
CCCCCCCCHHHCCCC		39.0020377248
53PhosphorylationDTDSDDISNRNNREI
CCCCHHHCCCCCCCC		36.4124961812
62PhosphorylationRNNREIGSVKSVQTK
CCCCCCCCEEEEEEC		31.8424961812
115PhosphorylationYCVRFNESFISRYYH
CEEECCHHHHHHHHH		29.0528889911
118PhosphorylationRFNESFISRYYHINK
ECCHHHHHHHHHHHC		16.5430377154
125AcetylationSRYYHINKVRNRKSY
HHHHHHHCCCCCHHH		41.8022865919
163PhosphorylationPNITISTSTKSAIQK
CCEEEECCCHHHHHH		27.3530377154
576PhosphorylationLYRLKELTTLVKKRT
HHHHHHHHHHHHHHH		21.1228889911
580AcetylationKELTTLVKKRTQASN
HHHHHHHHHHHHHCH		39.3824489116
588PhosphorylationKRTQASNSLSRSRKK
HHHHHCHHCCHHHHH		25.8119779198
590PhosphorylationTQASNSLSRSRKKVF
HHHCHHCCHHHHHHH		28.2019779198
592PhosphorylationASNSLSRSRKKVFDI
HCHHCCHHHHHHHHH		45.1119779198
728PhosphorylationIMEEEGLSDAEELSA
EECCCCCCCHHHHCC		45.7028889911
734PhosphorylationLSDAEELSAGEHRML
CCCHHHHCCCCHHHH		37.1919779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NTO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NTO1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NTO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSN8_YEASTSSN8genetic
17314980
REB1_YEASTREB1genetic
17314980
IES5_YEASTIES5genetic
17314980
ARP8_YEASTARP8genetic
17314980
IES3_YEASTIES3genetic
17314980
GET2_YEASTGET2genetic
17314980
SWD1_YEASTSWD1genetic
17314980
LRP1_YEASTLRP1genetic
17314980
IES1_YEASTIES1genetic
17314980
VPS72_YEASTVPS72genetic
17314980
RSC1_YEASTRSC1genetic
17314980
DEP1_YEASTDEP1genetic
17314980
H2AZ_YEASTHTZ1genetic
17314980
CLA4_YEASTCLA4genetic
17314980
SAP30_YEASTSAP30genetic
17314980
HAT1_YEASTHAT1genetic
17314980
RRP6_YEASTRRP6genetic
17314980
RXT2_YEASTRXT2genetic
17314980
RAD1_YEASTRAD1genetic
17314980
SWC5_YEASTSWC5genetic
17314980
PP4C_YEASTPPH3genetic
17314980
BUB3_YEASTBUB3genetic
17314980
RSC6_YEASTRSC6genetic
17314980
SSN3_YEASTSSN3genetic
17314980
PFD1_YEASTPFD1genetic
17314980
SSN2_YEASTSSN2genetic
17314980
SSB2_YEASTSSB2physical
19536198
SSB1_YEASTSSB1physical
19536198
HAA1_YEASTHAA1genetic
19547744
VPS71_YEASTVPS71genetic
19547744
SIN3_YEASTSIN3genetic
19547744
AF9_YEASTYAF9genetic
19547744
H3_YEASTHHT1physical
17142463
HDA1_YEASTHDA1genetic
21288874
COG4_YEASTCOG4genetic
21288874
VPS72_YEASTVPS72genetic
21288874
H2AZ_YEASTHTZ1genetic
20959818
IES5_YEASTIES5genetic
20959818
SWD1_YEASTSWD1genetic
20959818
HAA1_YEASTHAA1genetic
20959818
MED31_YEASTSOH1genetic
20959818
SPT3_YEASTSPT3genetic
20959818
SEF1_YEASTSEF1genetic
20959818
ARP8_YEASTARP8genetic
20959818
SIN3_YEASTSIN3genetic
20959818
VPS71_YEASTVPS71genetic
20959818
MED9_YEASTCSE2genetic
20959818
AATC_YEASTAAT2genetic
20959818
IME1_YEASTIME1genetic
20959818
AF9_YEASTYAF9genetic
20959818
GLN3_YEASTGLN3genetic
20959818
DOA1_YEASTDOA1genetic
20959818
YPT6_YEASTYPT6genetic
20959818
UBP3_YEASTUBP3genetic
20959818
GAL10_YEASTGAL10genetic
27708008
SNF5_YEASTSNF5genetic
27708008
GIT1_YEASTGIT1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
TRM1_YEASTTRM1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
FUN30_YEASTFUN30genetic
27708008
CALX_YEASTCNE1genetic
27708008
MUM2_YEASTMUM2genetic
27708008
NHP10_YEASTNHP10genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
YD109_YEASTYDL109Cgenetic
27708008
CYK3_YEASTCYK3genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
ARO1_YEASTARO1genetic
27708008
NUP42_YEASTNUP42genetic
27708008
PUR3_YEASTADE8genetic
27708008
PMD1_YEASTPMD1genetic
27708008
IES1_YEASTIES1genetic
27708008
MIC19_YEASTMIC19genetic
27708008
ELP2_YEASTELP2genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
ASF1_YEASTASF1genetic
27708008
YKH5_YEASTYKL075Cgenetic
27708008
PPR1_YEASTPPR1genetic
27708008
ALAM_YEASTALT1genetic
27708008
PAU4_YEASTPAU4genetic
27708008
RU2A_YEASTLEA1genetic
29674565
RV161_YEASTRVS161genetic
29674565
THRC_YEASTTHR4genetic
29674565
TPS2_YEASTTPS2genetic
29674565
ITR1_YEASTITR1genetic
29674565
CEM1_YEASTCEM1genetic
29674565
GET2_YEASTGET2genetic
29674565
IES1_YEASTIES1genetic
29674565
SLD3_YEASTSLD3genetic
29674565
HUR1_YEASTHUR1genetic
29674565
STB5_YEASTSTB5genetic
29674565
OST1_YEASTOST1genetic
29674565
GWT1_YEASTGWT1genetic
29674565
MTC1_YEASTMTC1genetic
29674565
VPS35_YEASTVPS35genetic
29674565
FABG_YEASTOAR1genetic
29674565
KTI12_YEASTKTI12genetic
29674565
YKZ1_YEASTYKR011Cgenetic
29674565
RIC1_YEASTRIC1genetic
29674565
POB3_YEASTPOB3genetic
29674565
NU188_YEASTNUP188genetic
29674565
ZRC1_YEASTZRC1genetic
29674565
RPC1_YEASTRPO31genetic
29674565
MED4_YEASTMED4genetic
29674565
PFD4_YEASTGIM3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NTO1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, AND MASSSPECTROMETRY.

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