ITR1_YEAST - dbPTM
ITR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITR1_YEAST
UniProt AC P30605
Protein Name Myo-inositol transporter 1
Gene Name ITR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 584
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Major transporter for myo-inositol..
Protein Sequence MGIHIPYLTSKTSQSNVGDAVGNADSVEFNSEHDSPSKRGKITLESHEIQRAPASDDEDRIQIKPVNDEDDTSVMITFNQSLSPFIITLTFVASISGFMFGYDTGYISSALISIGTDLDHKVLTYGEKEIVTAATSLGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLKRSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPWQQSELFPQNVRGIGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLELEEVQTILKDGFNIKASKALAKKRKQQVARVHELKYEPTQEIIEDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MGIHIPYLTSKTSQ
-CCCCCCCCCCCCCC		23.2419823750
9PhosphorylationGIHIPYLTSKTSQSN
CCCCCCCCCCCCCCC		23.4919823750
10PhosphorylationIHIPYLTSKTSQSNV
CCCCCCCCCCCCCCC		31.2019823750
11UbiquitinationHIPYLTSKTSQSNVG
CCCCCCCCCCCCCCC		47.1317644757
12PhosphorylationIPYLTSKTSQSNVGD
CCCCCCCCCCCCCCC		31.5922369663
13PhosphorylationPYLTSKTSQSNVGDA
CCCCCCCCCCCCCCC		35.0322369663
15PhosphorylationLTSKTSQSNVGDAVG
CCCCCCCCCCCCCCC		33.0022369663
26PhosphorylationDAVGNADSVEFNSEH
CCCCCCCCCEECCCC		22.5722369663
31PhosphorylationADSVEFNSEHDSPSK
CCCCEECCCCCCCCC		41.4522369663
35PhosphorylationEFNSEHDSPSKRGKI
EECCCCCCCCCCCCE		32.7422369663
37PhosphorylationNSEHDSPSKRGKITL
CCCCCCCCCCCCEEE		38.6522369663
38UbiquitinationSEHDSPSKRGKITLE
CCCCCCCCCCCEEEE		69.4323749301
41UbiquitinationDSPSKRGKITLESHE
CCCCCCCCEEEEEHH		36.2323749301
43PhosphorylationPSKRGKITLESHEIQ
CCCCCCEEEEEHHEE		28.1422890988
46PhosphorylationRGKITLESHEIQRAP
CCCEEEEEHHEECCC		29.5422369663
55PhosphorylationEIQRAPASDDEDRIQ
HEECCCCCCCCCCEE		44.5322369663
128UbiquitinationKVLTYGEKEIVTAAT
CEECCCHHHHHHHHH		48.6719722269
132PhosphorylationYGEKEIVTAATSLGA
CCHHHHHHHHHHHHH		19.0829688323
135PhosphorylationKEIVTAATSLGALIT
HHHHHHHHHHHHHHH		23.2429688323
136PhosphorylationEIVTAATSLGALITS
HHHHHHHHHHHHHHH		21.7829688323
142PhosphorylationTSLGALITSIFAGTA
HHHHHHHHHHHHHHH		19.3429688323
143PhosphorylationSLGALITSIFAGTAA
HHHHHHHHHHHHHHH		14.5529688323
148PhosphorylationITSIFAGTAADIFGR
HHHHHHHHHHHHHCC		18.4229688323
156UbiquitinationAADIFGRKRCLMGSN
HHHHHCCCCCCCCCC		48.0917644757
276AcetylationTPRYYVMKGDLARAT
CCCEEEECCHHHHHH		38.9524489116
276UbiquitinationTPRYYVMKGDLARAT
CCCEEEECCHHHHHH		38.9523749301
287UbiquitinationARATEVLKRSYTDTS
HHHHHHHHHHCCCCC		44.4617644757
289PhosphorylationATEVLKRSYTDTSEE
HHHHHHHHCCCCCHH		30.6921440633
290PhosphorylationTEVLKRSYTDTSEEI
HHHHHHHCCCCCHHH		16.8127717283
291PhosphorylationEVLKRSYTDTSEEII
HHHHHHCCCCCHHHH		33.7622369663
293PhosphorylationLKRSYTDTSEEIIER
HHHHCCCCCHHHHHH		30.1827717283
294PhosphorylationKRSYTDTSEEIIERK
HHHCCCCCHHHHHHH		35.7227717283
301UbiquitinationSEEIIERKVEELVTL
CHHHHHHHHHHHHHH		41.0023749301
315UbiquitinationLNQSIPGKNVPEKVW
HCCCCCCCCCCHHHH		49.7917644757
320UbiquitinationPGKNVPEKVWNTIKE
CCCCCCHHHHHHHHH		46.6217644757
326UbiquitinationEKVWNTIKELHTVPS
HHHHHHHHHHCCCCC		52.7817644757
371N-linked_GlycosylationFETVGFKNSSAVSII
EEECCCCCCCEEEEE		38.65-
573UbiquitinationVARVHELKYEPTQEI
HHHHHHCCCCCCHHH		44.5823749301
573AcetylationVARVHELKYEPTQEI
HHHHHHCCCCCCHHH		44.5824489116
574PhosphorylationARVHELKYEPTQEII
HHHHHCCCCCCHHHH		39.5022890988
577PhosphorylationHELKYEPTQEIIEDI
HHCCCCCCHHHHHCC		27.2222890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YG3A_YEASTYGR130Cphysical
18467557
MID2_YEASTMID2physical
18467557
HNM1_YEASTHNM1physical
18467557
ITR1_YEASTITR1physical
18467557
PLM2_YEASTPLM2physical
18467557
YMP0_YEASTYMR010Wphysical
18467557
PDR12_YEASTPDR12physical
18467557
MUP1_YEASTMUP1physical
18467557
TCB3_YEASTTCB3physical
18467557
KEX1_YEASTKEX1physical
18467557
FTR1_YEASTFTR1physical
18467557
ITR2_YEASTITR2genetic
18408719
MDM10_YEASTMDM10genetic
20093466
YD176_YEASTYDL176Wgenetic
20093466
MTU1_YEASTSLM3genetic
20093466
INO2_YEASTINO2genetic
20093466
YSP2_YEASTYSP2genetic
20093466
SIM1_YEASTSIM1genetic
20093466
PRY3_YEASTPRY3genetic
20093466
PAN3_YEASTPAN3genetic
20093466
ACE2_YEASTACE2genetic
20093466
SWI6_YEASTSWI6genetic
20093466
VRP1_YEASTVRP1genetic
20093466
RSC2_YEASTRSC2genetic
20093466
YMK8_YEASTYML108Wgenetic
20093466
NST1_YEASTNST1genetic
20093466
ITR2_YEASTITR2genetic
20093466
MDM12_YEASTMDM12genetic
20093466
PEX27_YEASTPEX27genetic
20093466
FUN26_YEASTFUN26physical
16093310
MGA2_YEASTMGA2genetic
19325107
ALG10_YEASTDIE2genetic
19325107
KEX2_YEASTKEX2genetic
19325107
LEM3_YEASTLEM3genetic
19325107
SWC5_YEASTSWC5genetic
19325107
COG4_YEASTCOG4genetic
21288874
UBP8_YEASTUBP8genetic
21288874
SLG1_YEASTSLG1genetic
20526336
ITR2_YEASTITR2genetic
20526336
6PGD1_YEASTGND1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
TPS1_YEASTTPS1genetic
21623372
SDHB_YEASTSDH2genetic
21623372
CEM1_YEASTCEM1genetic
21623372
ARO1_YEASTARO1genetic
21623372
TAM41_YEASTTAM41genetic
23623749
YD176_YEASTYDL176Wgenetic
27708008
YBB0_YEASTYBL010Cgenetic
27708008
ATM_YEASTTEL1genetic
27708008
RER1_YEASTRER1genetic
27708008
ATG15_YEASTATG15genetic
27708008
MTU1_YEASTSLM3genetic
27708008
INO2_YEASTINO2genetic
27708008
YSP2_YEASTYSP2genetic
27708008
MED5_YEASTNUT1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
MED20_YEASTSRB2genetic
27708008
CYT2_YEASTCYT2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
YMK8_YEASTYML108Wgenetic
27708008
NST1_YEASTNST1genetic
27708008
AF9_YEASTYAF9genetic
27708008
MDM12_YEASTMDM12genetic
27708008
ITR2_YEASTITR2genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery.";
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-573, AND MASSSPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-573, AND MASSSPECTROMETRY.

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