FTR1_YEAST - dbPTM
FTR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FTR1_YEAST
UniProt AC P40088
Protein Name Plasma membrane iron permease
Gene Name FTR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 404
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Permease for high affinity iron uptake..
Protein Sequence MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYRKLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMGIPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAVVFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLISAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKNKKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHVKADSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationLQKDIFGSAEDLWEG
HHCCCCCCHHHHHHH		20.1019779198
101PhosphorylationMIATIMISMMGIPML
HHHHHHHHHCCHHHH		5.8319779198
112AcetylationIPMLRMNKMQSKWRV
HHHHHHCCCCHHHHH		29.0425381059
115PhosphorylationLRMNKMQSKWRVKIA
HHHCCCCHHHHHHHH		30.5927017623
116AcetylationRMNKMQSKWRVKIAR
HHCCCCHHHHHHHHH		23.3325381059
137AcetylationHRKRDYFKIGFLSRR
CCCCCHHHHCCCCHH		35.3724489116
261UbiquitinationNGSYNIRKAVYHVNC
CCCCEEEEEEEEEEC		38.1117644757
325AcetylationRGHLPFTKNLQLKHL
CCCCCCCCCCCCCCC		56.9124489116
330AcetylationFTKNLQLKHLNPGYW
CCCCCCCCCCCCCCE		32.8424489116
339AcetylationLNPGYWIKNKKKQEL
CCCCCEECCHHHHHC		48.8724489116
341UbiquitinationPGYWIKNKKKQELTE
CCCEECCHHHHHCCH		57.2417644757
342UbiquitinationGYWIKNKKKQELTEE
CCEECCHHHHHCCHH		69.9117644757
343UbiquitinationYWIKNKKKQELTEEQ
CEECCHHHHHCCHHH		51.0917644757
351UbiquitinationQELTEEQKRQLFAKM
HHCCHHHHHHHHHHH		45.4523749301
381PhosphorylationNYELPEQTTSHSSSQ
CCCCCCCCCCCCCCC		28.7121551504
382PhosphorylationYELPEQTTSHSSSQN
CCCCCCCCCCCCCCC		24.9221440633
383PhosphorylationELPEQTTSHSSSQNV
CCCCCCCCCCCCCCC		25.4321551504
386PhosphorylationEQTTSHSSSQNVATD
CCCCCCCCCCCCCCC		30.4421440633
387PhosphorylationQTTSHSSSQNVATDK
CCCCCCCCCCCCCCC		28.8721551504
400UbiquitinationDKEVLHVKADSL---
CCEEEEEECCCC---		35.4123749301
403PhosphorylationVLHVKADSL------
EEEEECCCC------		40.6222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FTR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FTR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FTR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNX3_YEASTSNX3physical
17420293
YL326_YEASTYLR326Wphysical
18467557
HNM1_YEASTHNM1physical
18467557
FLC1_YEASTFLC1physical
18467557
HXT5_YEASTHXT5physical
18467557
HXT1_YEASTHXT1physical
18467557
PDR12_YEASTPDR12physical
18467557
YL413_YEASTINA1physical
18467557
MUP1_YEASTMUP1physical
18467557
TCB3_YEASTTCB3physical
18467557
TPO3_YEASTTPO3physical
18467557
KEX1_YEASTKEX1physical
18467557
SFK1_YEASTSFK1physical
18467557
FET3_YEASTFET3physical
18467557
TPO4_YEASTTPO4physical
18467557
TPO2_YEASTTPO2physical
18467557
YG3A_YEASTYGR130Cphysical
18467557
MID2_YEASTMID2physical
18467557
TPS1_YEASTTPS1genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
PALF_YEASTRIM8genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
THIK_YEASTPOT1genetic
20093466
PALI_YEASTRIM9genetic
20093466
RIM13_YEASTRIM13genetic
20093466
FET4_YEASTFET4genetic
20093466
DFG16_YEASTDFG16genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
FIMB_YEASTSAC6genetic
20526336
SHO1_YEASTSHO1genetic
20526336
PRM9_YEASTPRM9genetic
20526336
SRS2_YEASTSRS2genetic
21459050
YL326_YEASTYLR326Wphysical
22615397
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
FAS2_YEASTFAS2physical
22940862
VMA21_YEASTVMA21genetic
27708008
TPS1_YEASTTPS1genetic
27708008
STDH_YEASTCHA1genetic
27708008
PALF_YEASTRIM8genetic
27708008
HXKB_YEASTHXK2genetic
27708008
THIK_YEASTPOT1genetic
27708008
PALI_YEASTRIM9genetic
27708008
FET4_YEASTFET4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FTR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403, AND MASSSPECTROMETRY.

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