| UniProt ID | MID2_YEAST | |
|---|---|---|
| UniProt AC | P36027 | |
| Protein Name | Cell wall integrity sensor MID2 | |
| Gene Name | MID2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 376 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Localizes uniformly around the cell periphery. Also localized to the mother-bud junction. |
|
| Protein Description | Cell wall stress sensor. Involved in activation of a response that includes both stress-related increased chitin synthesis and the MPK1 mitogen-activated protein kinase cell integrity pathway. High-copy activator of the SKN7 transcription factor. Required during induction of MPK1 tyrosine phosphorylation under a variety of stress conditions. Required for PKC pathway activation under low pH conditions. Required for cell integrity signaling during pheromone-induced morphogenesis. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell wall integrity signaling.. | |
| Protein Sequence | MLSFTTKNSFRLLLLILSCISTIRAQFFVQSSSSNSSAVSTARSSVSRVSSSSSILSSSMVSSSSADSSSLTSSTSSRSLVSHTSSSTSIASISFTSFSFSSDSSTSSSSSASSDSSSSSSFSISSTSATSESSTSSTQTSTSSSSSLSSTPSSSSSPSTITSAPSTSSTPSTTAYNQGSTITSIINGKTILSNHYTTVTYTPSATADSSNKSKSSGLSKKNRNIVIGCVVGIGVPLILVILALIYMFCIQSSRTDFIDSDGKVVTAYRANKFTKWWYMLLGKKVSDEYHSDSPLGGSASSAGGLDLDEADDVMEQSSLFDVRIRDSDSVLPNANTADHNNTNSGGEPINSSVASNDIIEEKFYDEQGNELSPRNY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | N-linked_Glycosylation | FVQSSSSNSSAVSTA HHHCCCCCCCHHHHC | 41.76 | - | |
| 211 | N-linked_Glycosylation | SATADSSNKSKSSGL CCCCCCCCCCCCCCC | 57.48 | - | |
| 260 | Phosphorylation | SRTDFIDSDGKVVTA CCCCCCCCCCCEEEE | 43.37 | 28889911 | |
| 266 | Phosphorylation | DSDGKVVTAYRANKF CCCCCEEEEEECCCH | 22.43 | 19779198 | |
| 268 | Phosphorylation | DGKVVTAYRANKFTK CCCEEEEEECCCHHH | 10.82 | 19779198 | |
| 289 | Phosphorylation | GKKVSDEYHSDSPLG CCCCCCCCCCCCCCC | 16.18 | 19779198 | |
| 291 | Phosphorylation | KVSDEYHSDSPLGGS CCCCCCCCCCCCCCC | 38.59 | 19779198 | |
| 293 | Phosphorylation | SDEYHSDSPLGGSAS CCCCCCCCCCCCCCH | 25.66 | 27214570 | |
| 298 | Phosphorylation | SDSPLGGSASSAGGL CCCCCCCCCHHCCCC | 24.15 | 28132839 | |
| 300 | Phosphorylation | SPLGGSASSAGGLDL CCCCCCCHHCCCCCH | 23.55 | 28132839 | |
| 301 | Phosphorylation | PLGGSASSAGGLDLD CCCCCCHHCCCCCHH | 30.56 | 28132839 | |
| 317 | Phosphorylation | ADDVMEQSSLFDVRI HCHHHHHHCCEEEEE | 18.72 | 28132839 | |
| 318 | Phosphorylation | DDVMEQSSLFDVRIR CHHHHHHCCEEEEEC | 32.52 | 28132839 | |
| 327 | Phosphorylation | FDVRIRDSDSVLPNA EEEEECCCCCCCCCC | 23.18 | 29136822 | |
| 329 | Phosphorylation | VRIRDSDSVLPNANT EEECCCCCCCCCCCC | 29.52 | 29136822 | |
| 336 | Phosphorylation | SVLPNANTADHNNTN CCCCCCCCCCCCCCC | 30.93 | 29136822 | |
| 342 | Phosphorylation | NTADHNNTNSGGEPI CCCCCCCCCCCCCCC | 35.76 | 29136822 | |
| 344 | Phosphorylation | ADHNNTNSGGEPINS CCCCCCCCCCCCCCC | 46.25 | 29136822 | |
| 351 | Phosphorylation | SGGEPINSSVASNDI CCCCCCCCCCCCCCH | 27.23 | 29136822 | |
| 352 | Phosphorylation | GGEPINSSVASNDII CCCCCCCCCCCCCHH | 19.74 | 29136822 | |
| 355 | Phosphorylation | PINSSVASNDIIEEK CCCCCCCCCCHHHHH | 32.64 | 29136822 | |
| 364 | Phosphorylation | DIIEEKFYDEQGNEL CHHHHHHCCCCCCCC | 29.64 | 28132839 | |
| 372 | Phosphorylation | DEQGNELSPRNY--- CCCCCCCCCCCC--- | 18.68 | 21551504 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MID2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MID2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MID2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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