MTL1_YEAST - dbPTM
MTL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTL1_YEAST
UniProt AC P53214
Protein Name Protein MTL1
Gene Name MTL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 551
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description Involved in cell integrity signaling during vegetative growth at elevated temperature. Acts positively on the PKC1-MAPK pathway. Cell membrane sensor of oxidative stress in the cell integrity pathway upstream of PKC1. Required to transmit the oxidative signal to SLT2 and to restore the correct actin organization following oxidative stress. Multicopy suppressor of 1,3-beta-glucan synthase (GS) mutation. Also suppresses RGD1 null mutations..
Protein Sequence MASCNPTRKKSSASSLSMWRTILMALTTLPLSVLSQELVPANSTTSSTAPSITSLSAVESFTSSTDATSSASLSTPSIASVSFTSFPQSSSLLTLSSTLSSELSSSSMQVSSSSTSSSSSEVTSSSSSSSISPSSSSSTIISSSSSLPTFTVASTSSTVASSTLSTSSSLVISTSSSTFTFSSESSSSLISSSISTSVSTSSVYVPSSSTSSPPSSSSELTSSSYSSSSSSSTLFSYSSSFSSSSSSSSSSSSSSSSSSSSSSSYFTLSTSSSSSIYSSSSYPSFSSSSSSNPTSSITSTSASSSITPASEYSNLAKTITSIIEGQTILSNYYTTITYSPTASASSGKNSHHSGLSKKNRNIIIGCVVGIGAPLILILLILIYMFCVQPKKTDFIDSDGKIVTAYRSNIFTKIWYFLLGKKIGETERFSSDSPIGSNNIQNFGDIDPEDILNNDNPYTPKHTNVEGYDDDDDDDANDENLSSNFHNRGIDDQYSPTKSASYSMSNSNSQDYNDADEVMHDENIHRVYDDSEASIDENYYTKPNNGLNITNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
318PhosphorylationEYSNLAKTITSIIEG
HHHHHHHHHHHHHCC		24.7128889911
330PhosphorylationIEGQTILSNYYTTIT
HCCCEEEECCEEEEE		20.9528889911
332PhosphorylationGQTILSNYYTTITYS
CCEEEECCEEEEEEC		9.9828889911
333PhosphorylationQTILSNYYTTITYSP
CEEEECCEEEEEECC		11.1428889911
334PhosphorylationTILSNYYTTITYSPT
EEEECCEEEEEECCC		11.0228889911
397PhosphorylationKKTDFIDSDGKIVTA
CCCCCCCCCCCEEEE		43.3728889911
432PhosphorylationTERFSSDSPIGSNNI
CCCCCCCCCCCCCCC		21.9921440633
436PhosphorylationSSDSPIGSNNIQNFG
CCCCCCCCCCCCCCC		27.6821440633
481PhosphorylationDANDENLSSNFHNRG
CCCCCCHHHHHHHCC		34.5125533186
482PhosphorylationANDENLSSNFHNRGI
CCCCCHHHHHHHCCC		46.8323749301
493PhosphorylationNRGIDDQYSPTKSAS
HCCCCCCCCCCCCCC		24.5028889911
494PhosphorylationRGIDDQYSPTKSASY
CCCCCCCCCCCCCCC		22.0620377248
496PhosphorylationIDDQYSPTKSASYSM
CCCCCCCCCCCCCCC		31.5221551504
527PhosphorylationDENIHRVYDDSEASI
CCCCCCCCCCCCCCC		17.6222369663
530PhosphorylationIHRVYDDSEASIDEN
CCCCCCCCCCCCCCC		31.9722369663
533PhosphorylationVYDDSEASIDENYYT
CCCCCCCCCCCCCCC		26.9022369663
538PhosphorylationEASIDENYYTKPNNG
CCCCCCCCCCCCCCC		15.5122369663
539PhosphorylationASIDENYYTKPNNGL
CCCCCCCCCCCCCCC		21.6222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPH2_YEASTVPH2physical
16093310
MSN2_YEASTMSN2genetic
20388713
TOR1_YEASTTOR1genetic
20388713
RAS2_YEASTRAS2genetic
20388713
RHO1_YEASTRHO1genetic
20388713
BCK1_YEASTBCK1genetic
20388713
EAR1_YEASTEAR1genetic
20526336
SWA2_YEASTSWA2genetic
20526336
SFP1_YEASTSFP1genetic
21331237
RAS2_YEASTRAS2genetic
21331237
TOR1_YEASTTOR1genetic
21331237
ROM2_YEASTROM2physical
22960125
PMT2_YEASTPMT2genetic
22960125
PMT1_YEASTPMT1genetic
22960125
KRE9_YEASTKRE9genetic
23891562
GPI13_YEASTGPI13genetic
23891562
COG4_YEASTCOG4genetic
23891562
TOR1_YEASTTOR1genetic
25855033
RAS2_YEASTRAS2genetic
25855033
KAPR_YEASTBCY1genetic
25855033
MID2_YEASTMID2genetic
24260614
SLG1_YEASTSLG1genetic
24260614
GPR1_YEASTGPR1genetic
27708008
FMP45_YEASTFMP45genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ERG3_YEASTERG3genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTL1_YEAST

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Related Literatures of Post-Translational Modification

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