| UniProt ID | MSN2_YEAST | |
|---|---|---|
| UniProt AC | P33748 | |
| Protein Name | Zinc finger protein MSN2 | |
| Gene Name | MSN2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 704 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity.. | |
| Protein Sequence | MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDIKNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRDARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTINPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNNLNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDDDDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTSSSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNKSACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTGLSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRKSMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKKHGDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 110 | Phosphorylation | ARTIENDSEIKSTNN CCEECCCHHCCCCCC | 53.45 | 30377154 | |
| 193 | Phosphorylation | SPRAQQHTSIKDNRL CCCHHHCCCCCCCCC | 28.01 | 19779198 | |
| 194 | Phosphorylation | PRAQQHTSIKDNRLS CCHHHCCCCCCCCCC | 26.05 | 23749301 | |
| 196 | Acetylation | AQQHTSIKDNRLSLP HHHCCCCCCCCCCCC | 49.03 | 25381059 | |
| 201 | Phosphorylation | SIKDNRLSLPNGANS CCCCCCCCCCCCCCC | 38.24 | 22369663 | |
| 208 | Phosphorylation | SLPNGANSNLFIDTN CCCCCCCCCEEECCC | 34.08 | 24909858 | |
| 222 | Acetylation | NPNNLNEKLRNQLNS CCCCHHHHHHHHHHC | 52.23 | 24489116 | |
| 288 | Phosphorylation | NLSRRRFSDVITNQF CHHHHHHHHHHHHCC | 29.20 | 22369663 | |
| 292 | Phosphorylation | RRFSDVITNQFPSMT HHHHHHHHHCCCCCC | 23.86 | 22369663 | |
| 299 | Phosphorylation | TNQFPSMTNSRNSIS HHCCCCCCCCCCCCC | 34.09 | 21440633 | |
| 304 | Phosphorylation | SMTNSRNSISHSLDL CCCCCCCCCCCCHHC | 25.10 | 22369663 | |
| 306 | Phosphorylation | TNSRNSISHSLDLWN CCCCCCCCCCHHCCC | 13.57 | 22369663 | |
| 308 | Phosphorylation | SRNSISHSLDLWNHP CCCCCCCCHHCCCCC | 19.45 | 22369663 | |
| 316 | Acetylation | LDLWNHPKINPSNRN HHCCCCCCCCCCCCC | 47.79 | 24489116 | |
| 324 | Phosphorylation | INPSNRNTNLNITTN CCCCCCCCCCEEEEC | 37.53 | 21440633 | |
| 329 | Phosphorylation | RNTNLNITTNSTSSS CCCCCEEEECCCCCC | 20.89 | 30377154 | |
| 330 | Phosphorylation | NTNLNITTNSTSSSN CCCCEEEECCCCCCC | 24.31 | 30377154 | |
| 332 | Phosphorylation | NLNITTNSTSSSNAS CCEEEECCCCCCCCC | 27.81 | 21551504 | |
| 333 | Phosphorylation | LNITTNSTSSSNASP CEEEECCCCCCCCCC | 34.40 | 21440633 | |
| 334 | Phosphorylation | NITTNSTSSSNASPN EEEECCCCCCCCCCC | 31.43 | 21551504 | |
| 335 | Phosphorylation | ITTNSTSSSNASPNT EEECCCCCCCCCCCC | 27.92 | 21551504 | |
| 336 | Phosphorylation | TTNSTSSSNASPNTT EECCCCCCCCCCCCC | 35.86 | 21551504 | |
| 339 | Phosphorylation | STSSSNASPNTTTMN CCCCCCCCCCCCCCC | 23.96 | 21440633 | |
| 342 | Phosphorylation | SSNASPNTTTMNANA CCCCCCCCCCCCCCC | 27.33 | 21551504 | |
| 343 | Phosphorylation | SNASPNTTTMNANAD CCCCCCCCCCCCCCC | 30.59 | 30377154 | |
| 344 | Phosphorylation | NASPNTTTMNANADS CCCCCCCCCCCCCCC | 13.34 | 30377154 | |
| 351 | Phosphorylation | TMNANADSNIAGNPK CCCCCCCCCCCCCCC | 27.94 | 27017623 | |
| 397 | Phosphorylation | KNKSACPSSFDANAM CCCCCCCCCCCCCCC | 43.45 | 30377154 | |
| 398 | Phosphorylation | NKSACPSSFDANAMT CCCCCCCCCCCCCCC | 16.58 | 30377154 | |
| 426 | Phosphorylation | RVQHKQLTSSHNNSS HHHHHHHHHCCCCCC | 26.20 | 22369663 | |
| 427 | Phosphorylation | VQHKQLTSSHNNSST HHHHHHHHCCCCCCC | 37.89 | 22369663 | |
| 428 | Phosphorylation | QHKQLTSSHNNSSTN HHHHHHHCCCCCCCC | 25.62 | 22369663 | |
| 432 | Phosphorylation | LTSSHNNSSTNMKSF HHHCCCCCCCCCHHH | 43.80 | 22369663 | |
| 433 | Phosphorylation | TSSHNNSSTNMKSFN HHCCCCCCCCCHHHC | 26.39 | 22369663 | |
| 434 | Phosphorylation | SSHNNSSTNMKSFNS HCCCCCCCCCHHHCH | 38.87 | 22369663 | |
| 438 | Phosphorylation | NSSTNMKSFNSDLYS CCCCCCHHHCHHHHH | 20.92 | 24961812 | |
| 441 | Phosphorylation | TNMKSFNSDLYSRRQ CCCHHHCHHHHHHHH | 27.29 | 22369663 | |
| 445 | Phosphorylation | SFNSDLYSRRQRASL HHCHHHHHHHHHCCC | 28.43 | 24961812 | |
| 451 | Phosphorylation | YSRRQRASLPIIDDS HHHHHHCCCCEECCC | 36.55 | 22369663 | |
| 458 | Phosphorylation | SLPIIDDSLSYDLVN CCCEECCCCCCCCCC | 18.57 | 22369663 | |
| 460 | Phosphorylation | PIIDDSLSYDLVNKQ CEECCCCCCCCCCCC | 22.13 | 22369663 | |
| 461 | Phosphorylation | IIDDSLSYDLVNKQD EECCCCCCCCCCCCC | 20.70 | 22369663 | |
| 495 | Phosphorylation | IKPSMILSDNASVIA CCHHHEECCCHHHHH | 20.21 | 24961812 | |
| 499 | Phosphorylation | MILSDNASVIAKVAT HEECCCHHHHHHHHH | 21.95 | 24961812 | |
| 582 | Phosphorylation | SSLRRRKSAVPLMGT HHHHHHCCCCCEEEE | 32.46 | 22369663 | |
| 589 | Phosphorylation | SAVPLMGTVPLTNQQ CCCCEEEEECCCCCC | 12.65 | 22369663 | |
| 593 | Phosphorylation | LMGTVPLTNQQNNIS EEEEECCCCCCCCCC | 25.55 | 21440633 | |
| 600 | Phosphorylation | TNQQNNISSSSVNST CCCCCCCCCCCCCCC | 26.70 | 21440633 | |
| 601 | Phosphorylation | NQQNNISSSSVNSTG CCCCCCCCCCCCCCC | 23.88 | 22369663 | |
| 602 | Phosphorylation | QQNNISSSSVNSTGN CCCCCCCCCCCCCCC | 31.36 | 21440633 | |
| 603 | Phosphorylation | QNNISSSSVNSTGNG CCCCCCCCCCCCCCC | 27.54 | 22369663 | |
| 606 | Phosphorylation | ISSSSVNSTGNGAGV CCCCCCCCCCCCCCC | 35.22 | 21440633 | |
| 607 | Phosphorylation | SSSSVNSTGNGAGVT CCCCCCCCCCCCCCC | 29.48 | 21440633 | |
| 614 | Phosphorylation | TGNGAGVTKERRPSY CCCCCCCCCCCCCCC | 26.69 | 22369663 | |
| 620 | Phosphorylation | VTKERRPSYRRKSMT CCCCCCCCCCCCCCC | 29.47 | 16445868 | |
| 621 | Phosphorylation | TKERRPSYRRKSMTP CCCCCCCCCCCCCCC | 19.67 | 24961812 | |
| 625 | Phosphorylation | RPSYRRKSMTPSRRS CCCCCCCCCCCCHHC | 26.52 | 22369663 | |
| 627 | Phosphorylation | SYRRKSMTPSRRSSV CCCCCCCCCCHHCCE | 25.79 | 22369663 | |
| 629 | Phosphorylation | RRKSMTPSRRSSVVI CCCCCCCCHHCCEEE | 31.03 | 20377248 | |
| 632 | Phosphorylation | SMTPSRRSSVVIEST CCCCCHHCCEEEECC | 26.78 | 22890988 | |
| 633 | Phosphorylation | MTPSRRSSVVIESTK CCCCHHCCEEEECCH | 20.70 | 22369663 | |
| 638 | Phosphorylation | RSSVVIESTKELEEK HCCEEEECCHHHHCC | 33.39 | 20377248 | |
| 639 | Phosphorylation | SSVVIESTKELEEKP CCEEEECCHHHHCCC | 18.75 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MSN2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MSN2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MSN2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-451 ANDSER-633, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304 AND SER-633, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-620, AND MASSSPECTROMETRY. | |
