PNC1_YEAST - dbPTM
PNC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PNC1_YEAST
UniProt AC P53184
Protein Name Nicotinamidase
Gene Name PNC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 216
Subcellular Localization Cytoplasm . Nucleus . Peroxisome . Concentrates in peroxisomes (PubMed:12736687).
Protein Description Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate..
Protein Sequence MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MKTLIVVDMQ
-----CCEEEEEECC		22.0330377154
15PhosphorylationDMQNDFISPLGSLTV
ECCCCCCCCCCCCEE		17.6730377154
19PhosphorylationDFISPLGSLTVPKGE
CCCCCCCCCEECCCC		28.6630377154
21PhosphorylationISPLGSLTVPKGEEL
CCCCCCCEECCCCHH		36.1430377154
59PhosphorylationWHPSRHISFAKNHKD
CCHHHHCCCCCCCCC		17.0228889911
62AcetylationSRHISFAKNHKDKEP
HHHCCCCCCCCCCCC		58.5424489116
71PhosphorylationHKDKEPYSTYTYHSP
CCCCCCCCCCEECCC		26.1721440633
77PhosphorylationYSTYTYHSPRPGDDS
CCCCEECCCCCCCCC		16.5219779198
84PhosphorylationSPRPGDDSTQEGILW
CCCCCCCCCCCCEEE		36.4128889911
1182-HydroxyisobutyrylationQVVTKHIKIVDKGFL
HHHHHCEEEEECCCC		36.07-
122UbiquitinationKHIKIVDKGFLTDRE
HCEEEEECCCCCCHH		40.4423749301
1222-HydroxyisobutyrylationKHIKIVDKGFLTDRE
HCEEEEECCCCCCHH		40.44-
122AcetylationKHIKIVDKGFLTDRE
HCEEEEECCCCCCHH		40.4424489116
142AcetylationHDIWNFHKTDMNKYL
HHHHHCHHHHHHHHH		41.9224489116
147AcetylationFHKTDMNKYLEKHHT
CHHHHHHHHHHHHCC		44.5724489116
174PhosphorylationCVKATAISAAELGYK
HHHHHHHCHHHHCCC		20.9728889911
201AcetylationDDPEVINKVKEELKA
CCHHHHHHHHHHHHH		43.4924489116
207AcetylationNKVKEELKAHNINVV
HHHHHHHHHCCCCCC		51.3722865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PNC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PNC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PNC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PNC1_YEASTPNC1physical
18719252
IDH1_YEASTIDH1genetic
19138656
IDH2_YEASTIDH2genetic
19138656
ARGJ_YEASTARG7genetic
21623372
DS1P1_YEASTLCB3genetic
21623372
COX9_YEASTCOX9genetic
21623372
THRC_YEASTTHR4genetic
21623372
CYC1_YEASTCYC1genetic
21623372
METC_YEASTIRC7genetic
21623372
GPD1_YEASTGPD1physical
26516056
SEC18_YEASTSEC18genetic
27708008
CDC13_YEASTCDC13genetic
27708008
UBC3_YEASTCDC34genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PANK_YEASTCAB1genetic
27708008
HACD_YEASTPHS1genetic
27708008
PRP21_YEASTPRP21genetic
27708008
ERG27_YEASTERG27genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
PRP2_YEASTPRP2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SNT1_YEASTSNT1genetic
27708008
CG23_YEASTCLB3genetic
27708008
HBT1_YEASTHBT1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
INO2_YEASTINO2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
FPS1_YEASTFPS1genetic
27708008
UBX2_YEASTUBX2genetic
27708008
SIR2_YEASTSIR2genetic
27799288
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PNC1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND MASSSPECTROMETRY.

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