DS1P1_YEAST - dbPTM
DS1P1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DS1P1_YEAST
UniProt AC P47013
Protein Name Dihydrosphingosine 1-phosphate phosphatase LCB3
Gene Name LCB3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 409
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling..
Protein Sequence MVDGLNTSNIRKRARTLSNPNDFQEPNYLLDPGNHPSDHFRTRMSKFRFNIREKLLVFTNNQSFTLSRWQKKYRSAFNDLYFTYTSLMGSHTFYVLCLPMPVWFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRITLSEYTTKEYGAPSSHTANATGVSLLFLYNIWRMQESSVMVQLLLSCVVLFYYMTLVFGRIYCGMHGILDLVSGGLIGIVCFIVRMYFKYRFPGLRIEEHWWFPLFSVGWGLLLLFKHVKPVDECPCFQDSVAFMGVVSGIECCDWLGKVFGVTLVYNLEPNCGWRLTLARLLVGLPCVVIWKYVISKPMIYTLLIKVFHLKDDRNVAARKRLEATHKEGASKYECPLYIGEPKIDILGRFIIYAGVPFTVVMCSPVLFSLLNIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMVDGLNTSNIRKRAR
CCCCCCHHHHHHHHH		29.2330377154
16PhosphorylationNIRKRARTLSNPNDF
HHHHHHHCCCCCCCC		33.2922369663
18PhosphorylationRKRARTLSNPNDFQE
HHHHHCCCCCCCCCC		50.0212786943
28PhosphorylationNDFQEPNYLLDPGNH
CCCCCCCCCCCCCCC		21.2522369663
37PhosphorylationLDPGNHPSDHFRTRM
CCCCCCCCHHHHHCH		35.8528889911
42PhosphorylationHPSDHFRTRMSKFRF
CCCHHHHHCHHHHCC		29.7624961812
45PhosphorylationDHFRTRMSKFRFNIR
HHHHHCHHHHCCCCC		25.9224961812
115PhosphorylationETTKDMVYILGYSIY
CCCHHHHHHHHHHHH		5.4724930733
119PhosphorylationDMVYILGYSIYLSGF
HHHHHHHHHHHHCCC		6.6124930733
366PhosphorylationATHKEGASKYECPLY
HHHHCCCCCCCCCEE		46.7828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DS1P1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DS1P1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DS1P1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSK22_YEASTCKA2genetic
12684378
ELO3_YEASTELO3genetic
12684378
DS1P2_YEASTYSR3genetic
10477278
SGPL_YEASTDPL1genetic
9973338
SVF1_YEASTSVF1genetic
17057230
TSC3_YEASTTSC3genetic
16269340
SGPL_YEASTDPL1genetic
16269340
HACD_YEASTPHS1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
PMA1_YEASTPMA1genetic
16269340
SUR2_YEASTSUR2genetic
16269340
ATC1_YEASTPMR1genetic
16269340
SEC66_YEASTSEC66genetic
16269340
ATG27_YEASTATG27genetic
16269340
SSH1_YEASTSSH1genetic
16269340
PHO90_YEASTPHO90genetic
16269340
GWT1_YEASTGWT1genetic
16269340
JEM1_YEASTJEM1genetic
16269340
LCB2_YEASTLCB2genetic
16269340
ARV1_YEASTARV1genetic
16269340
ILM1_YEASTILM1genetic
16269340
GET2_YEASTGET2genetic
16269340
ORM2_YEASTORM2genetic
16269340
ICE2_YEASTICE2genetic
16269340
SCS7_YEASTSCS7genetic
16269340
PEX29_YEASTPEX29physical
18719252
USA1_YEASTUSA1physical
18719252
SUR2_YEASTSUR2genetic
11102354
LCB4_YEASTLCB4genetic
11102354
SGPL_YEASTDPL1genetic
11102354
RV161_YEASTRVS161genetic
20526336
SCS7_YEASTSCS7genetic
20526336
SLG1_YEASTSLG1genetic
20526336
ELO3_YEASTELO3genetic
20526336
SUR2_YEASTSUR2genetic
20526336
ROM2_YEASTROM2genetic
20526336
SGPL_YEASTDPL1genetic
21623372
ERG2_YEASTERG2genetic
21623372
SUR2_YEASTSUR2genetic
21623372
ELO2_YEASTELO2genetic
21623372
PDX3_YEASTPDX3genetic
21623372
ELO3_YEASTELO3genetic
21623372
6PGD1_YEASTGND1genetic
21623372
THDH_YEASTILV1genetic
21623372
KCS1_YEASTKCS1genetic
21623372
ATPO_YEASTATP5genetic
21623372
LIP1_YEASTLIP1genetic
23891562
LCB2_YEASTLCB2genetic
23891562
LAC1_YEASTLAC1genetic
23891562
RV161_YEASTRVS161genetic
23891562
ARV1_YEASTARV1genetic
23891562
SAC7_YEASTSAC7genetic
23891562
ATC1_YEASTPMR1genetic
23891562
GAS1_YEASTGAS1genetic
23891562
PSD1_YEASTPSD1genetic
23891562
NHX1_YEASTNHX1genetic
23891562
GET2_YEASTGET2genetic
23891562
TLG2_YEASTTLG2genetic
23891562
CLA4_YEASTCLA4genetic
23891562
SRO7_YEASTSRO7genetic
23891562
MSMO_YEASTERG25genetic
23891562
ELO3_YEASTELO3genetic
23891562
CSG2_YEASTCSG2genetic
23891562
PHO88_YEASTPHO88genetic
23891562
ICE2_YEASTICE2genetic
23891562
STE50_YEASTSTE50genetic
27708008
ELO2_YEASTELO2genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
ELM1_YEASTELM1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ELO3_YEASTELO3genetic
27708008
YL407_YEASTYLR407Wgenetic
27708008
BUL2_YEASTBUL2genetic
27708008
PET8_YEASTPET8genetic
27708008
HDA1_YEASTHDA1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
CSK22_YEASTCKA2genetic
27708008
PDE2_YEASTPDE2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
VPS4_YEASTVPS4genetic
27708008
RSB1_YEASTRSB1genetic
27803077
KASH5_HUMANCCDC155physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DS1P1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-16 AND SER-18, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.

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