RSB1_YEAST - dbPTM
RSB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RSB1_YEAST
UniProt AC Q08417
Protein Name Sphingoid long-chain base transporter RSB1
Gene Name RSB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 382
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels..
Protein Sequence MSNATNNTLGSLLPQLEAAANSNSLYGGMVPNLRFNITMIVIWGILLTIHVVQLLMRQYWFSIAFICTGILEVLGFIGRTWSHSNVADMDAFLLNMICLTIAPVFTMGGIYYQLAKLIEVYGHRFSLLPSPMAYSFIFICSDIVSLVVQAVGGGLCGVAVTDGTSTTTGNHVFIAGLAIQVASMAIFLMLWFHFLFRIYISVRWEHINSRPISLSLLKISQTEVDYLYREKFHFLRLEPKRWVFHYFNLAITVAVLTIFTRCCYRLAELVVGWDGYLITHEWYFIILDALMMAIATVTLTIFHPGFAFKGRSTSIPITPGHVDPETLPHTDDVEDILDTSDSKQFDIEKEEFQASMKYPISTFKQFMSKIANLFSSKKKAKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3N-linked_Glycosylation-----MSNATNNTLG
-----CCCCCCCHHH		49.8616407254
6N-linked_Glycosylation--MSNATNNTLGSLL
--CCCCCCCHHHHHH		36.7616407254
312PhosphorylationGFAFKGRSTSIPITP
CCCCCCCCCCCCCCC		34.8622369663
313PhosphorylationFAFKGRSTSIPITPG
CCCCCCCCCCCCCCC		29.3422369663
314PhosphorylationAFKGRSTSIPITPGH
CCCCCCCCCCCCCCC		27.8422369663
318PhosphorylationRSTSIPITPGHVDPE
CCCCCCCCCCCCCHH		20.1922369663
326PhosphorylationPGHVDPETLPHTDDV
CCCCCHHHCCCCCCH		51.4822369663
330PhosphorylationDPETLPHTDDVEDIL
CHHHCCCCCCHHHHH		31.7722369663
339PhosphorylationDVEDILDTSDSKQFD
CHHHHHCCCCCCCCC		30.8722369663
340PhosphorylationVEDILDTSDSKQFDI
HHHHHCCCCCCCCCC		39.2822369663
342PhosphorylationDILDTSDSKQFDIEK
HHHCCCCCCCCCCCH		28.2922369663
355PhosphorylationEKEEFQASMKYPIST
CHHHHHHHCCCCHHH		12.6727717283
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RSB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RSB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RSB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERP4_YEASTERP4genetic
16269340
ALG6_YEASTALG6genetic
16269340
HRD1_YEASTHRD1genetic
16269340
PGA3_YEASTPGA3genetic
16269340
SWC5_YEASTSWC5genetic
19547744
SIN3_YEASTSIN3genetic
19547744
PLB3_YEASTPLB3genetic
19547744
IWR1_YEASTIWR1genetic
19547744
TPS1_YEASTTPS1genetic
20093466
SEC66_YEASTSEC66genetic
20093466
RV161_YEASTRVS161genetic
20093466
RV167_YEASTRVS167genetic
20093466
HAP2_YEASTHAP2genetic
20093466
AAKG_YEASTSNF4genetic
20093466
PACC_YEASTRIM101genetic
20093466
COPE_YEASTSEC28genetic
20093466
HAP4_YEASTHAP4genetic
20093466
FABG_YEASTOAR1genetic
20093466
NU133_YEASTNUP133genetic
20093466
VRP1_YEASTVRP1genetic
20093466
MUB1_YEASTMUB1genetic
20093466
YM35_YEASTYMR160Wgenetic
20093466
SSO2_YEASTSSO2genetic
20093466
NST1_YEASTNST1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
EOS1_YEASTEOS1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
YAR1_YEASTYAR1genetic
20093466
YOR1_YEASTYOR1genetic
20826817
PDR5_YEASTPDR5genetic
20826817
BUL1_YEASTBUL1genetic
20826817
MDM10_YEASTMDM10genetic
21987634
LONM_YEASTPIM1genetic
21987634
UGO1_YEASTUGO1genetic
21987634
VPS52_YEASTVPS52genetic
21987634
MDJ1_YEASTMDJ1genetic
21987634
GCN5_YEASTGCN5genetic
21987634
ZUO1_YEASTZUO1genetic
21987634
GEP4_YEASTGEP4genetic
21987634
MMM1_YEASTMMM1genetic
21987634
PGA3_YEASTPGA3genetic
21987634
PLB3_YEASTPLB3genetic
21987634
H2AZ_YEASTHTZ1genetic
21987634
ALG6_YEASTALG6genetic
21987634
ERP4_YEASTERP4genetic
21987634
VATL2_YEASTVMA11genetic
21987634
MSC2_YEASTMSC2genetic
27708008
FAT1_YEASTFAT1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
SEC66_YEASTSEC66genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RV161_YEASTRVS161genetic
27708008
GPR1_YEASTGPR1genetic
27708008
EBS1_YEASTEBS1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
PMP3_YEASTPMP3genetic
27708008
SNF1_YEASTSNF1genetic
27708008
CHD1_YEASTCHD1genetic
27708008
UBP6_YEASTUBP6genetic
27708008
AAKG_YEASTSNF4genetic
27708008
RTF1_YEASTRTF1genetic
27708008
QCR9_YEASTQCR9genetic
27708008
GSH1_YEASTGSH1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
PSR1_YEASTPSR1genetic
27708008
SRN2_YEASTSRN2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
MSC1_YEASTMSC1genetic
27708008
MUB1_YEASTMUB1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
SWS2_YEASTSWS2genetic
27708008
FAR11_YEASTFAR11genetic
27708008
VPS27_YEASTVPS27genetic
27708008
ATP23_YEASTATP23genetic
27708008
BRE5_YEASTBRE5genetic
27708008
LGE1_YEASTLGE1genetic
27708008
YME1_YEASTYME1genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RSB1_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Long chain base tolerance in Saccharomyces cerevisiae is induced byretrograde signals from the mitochondria.";
Panwar S.L., Moye-Rowley W.S.;
J. Biol. Chem. 281:6376-6384(2006).
Cited for: IDENTIFICATION OF FRAMESHIFT, SUBCELLULAR LOCATION, GLYCOSYLATION ATASN-3 AND ASN-6, INDUCTION, AND MUTAGENESIS OF ASN-3 AND ASN-6.

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