PSR1_YEAST - dbPTM
PSR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSR1_YEAST
UniProt AC Q07800
Protein Name Phosphatase PSR1
Gene Name PSR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 427
Subcellular Localization Cell membrane .
Protein Description Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2..
Protein Sequence MGFISSILCCSSETTQSNSNSAYRQQQSSSLNKNRSVKHSNTKSRTRGVHQTNSPPSKTNSAATFSSTERSTGKSGISTNDNEKKKPSSPTAAVTATTTNNMTKVEKRISKDDLYEEKYEVDEDEEIDDEDNRRSRGIVQEKGDAVKDTSRQKKQQQQQQQQSQPQPQPQSQSQSQSQSQSQQRGPTVQVSSDHLIQDMNLSRVSSSSQASETSNDADDEDDEDEEYIDLTLLQQGQYHAPGYNTLLPPQDESTKGKKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDVGKILDVTI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9S-palmitoylationGFISSILCCSSETTQ
CCCCEEEECCCCCCC		1.7010777497
10S-palmitoylationFISSILCCSSETTQS
CCCEEEECCCCCCCC		4.4910777497
30PhosphorylationYRQQQSSSLNKNRSV
HHHHHHHHCCCCCCC		41.0028889911
52PhosphorylationRTRGVHQTNSPPSKT
CCCCCCCCCCCCCCC		23.8421440633
54PhosphorylationRGVHQTNSPPSKTNS
CCCCCCCCCCCCCCC		41.3923749301
57PhosphorylationHQTNSPPSKTNSAAT
CCCCCCCCCCCCCCC		56.3423749301
58UbiquitinationQTNSPPSKTNSAATF
CCCCCCCCCCCCCCE		58.4623749301
59PhosphorylationTNSPPSKTNSAATFS
CCCCCCCCCCCCCEE		38.4522369663
61PhosphorylationSPPSKTNSAATFSST
CCCCCCCCCCCEECC		25.2222369663
64PhosphorylationSKTNSAATFSSTERS
CCCCCCCCEECCCCC		24.6222369663
66PhosphorylationTNSAATFSSTERSTG
CCCCCCEECCCCCCC		31.8120377248
67PhosphorylationNSAATFSSTERSTGK
CCCCCEECCCCCCCC		30.0522369663
68PhosphorylationSAATFSSTERSTGKS
CCCCEECCCCCCCCC		33.9322369663
71PhosphorylationTFSSTERSTGKSGIS
CEECCCCCCCCCCCC		34.9719823750
72PhosphorylationFSSTERSTGKSGIST
EECCCCCCCCCCCCC		55.6524961812
74UbiquitinationSTERSTGKSGISTND
CCCCCCCCCCCCCCC		45.6723749301
75PhosphorylationTERSTGKSGISTNDN
CCCCCCCCCCCCCCC		42.5828889911
78PhosphorylationSTGKSGISTNDNEKK
CCCCCCCCCCCCCCC		25.3625521595
79PhosphorylationTGKSGISTNDNEKKK
CCCCCCCCCCCCCCC		44.6728889911
84UbiquitinationISTNDNEKKKPSSPT
CCCCCCCCCCCCCCC		72.8023749301
88PhosphorylationDNEKKKPSSPTAAVT
CCCCCCCCCCCEEEE		58.8021440633
89PhosphorylationNEKKKPSSPTAAVTA
CCCCCCCCCCEEEEE		34.4921440633
91PhosphorylationKKKPSSPTAAVTATT
CCCCCCCCEEEEEEC		29.2421440633
95PhosphorylationSSPTAAVTATTTNNM
CCCCEEEEEECCCCC		17.3527017623
103PhosphorylationATTTNNMTKVEKRIS
EECCCCCHHHEEECC		33.7821440633
110PhosphorylationTKVEKRISKDDLYEE
HHHEEECCHHHHHHH		33.7822369663
111UbiquitinationKVEKRISKDDLYEEK
HHEEECCHHHHHHHH		53.5423749301
115PhosphorylationRISKDDLYEEKYEVD
ECCHHHHHHHHCCCC		29.0922890988
142UbiquitinationSRGIVQEKGDAVKDT
CCCCHHHHHHHHHHH		45.0323749301
150PhosphorylationGDAVKDTSRQKKQQQ
HHHHHHHHHHHHHHH		42.7325533186
154UbiquitinationKDTSRQKKQQQQQQQ
HHHHHHHHHHHHHHH		45.0323749301
173PhosphorylationQPQPQSQSQSQSQSQ
CCCCCCHHHHHHHHH		36.7323749301
177PhosphorylationQSQSQSQSQSQSQQR
CCHHHHHHHHHHHHC		36.7323749301
181PhosphorylationQSQSQSQSQQRGPTV
HHHHHHHHHHCCCCE		33.2628889911
187PhosphorylationQSQQRGPTVQVSSDH
HHHHCCCCEEECHHH		26.7922369663
191PhosphorylationRGPTVQVSSDHLIQD
CCCCEEECHHHHHHC		16.9822369663
192PhosphorylationGPTVQVSSDHLIQDM
CCCEEECHHHHHHCC		30.1422369663
258UbiquitinationDESTKGKKCLILDLD
CCCCCCCEEEEEECC		42.8317644757
274UbiquitinationTLVHSSFKYLRSADF
HHHHHHHHHHHHCCE		45.3717644757
319PhosphorylationLFEVVVFTASVSRYG
HEEEEEEEEEHHHHC		13.3527017623
323PhosphorylationVVFTASVSRYGDPLL
EEEEEEHHHHCCCHH		19.7927017623
335PhosphorylationPLLDILDTDKVIHHR
CHHHHHCCCCCHHHH		33.9827017623
337AcetylationLDILDTDKVIHHRLF
HHHHCCCCCHHHHHH		45.2224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WHI2_YEASTWHI2physical
11805837
PSR2_YEASTPSR2genetic
12090248
PUT3_YEASTPUT3physical
16554755
PSR2_YEASTPSR2physical
16554755
WHI2_YEASTWHI2physical
16554755
PSR2_YEASTPSR2genetic
10777497
ATN1_YEASTENA1genetic
10777497
WHI2_YEASTWHI2physical
18719252
HSP71_YEASTSSA1physical
19536198
YPQ3_YEASTRTC2genetic
20093466
AIM4_YEASTAIM4genetic
20093466
PYC2_YEASTPYC2genetic
20093466
EMI1_YEASTEMI1genetic
20093466
UBP3_YEASTUBP3genetic
20093466
RPOM_YEASTRPO41genetic
20093466
MED5_YEASTNUT1genetic
20093466
MED20_YEASTSRB2genetic
20093466
VRP1_YEASTVRP1genetic
20093466
HAL9_YEASTHAL9genetic
20093466
SIN3_YEASTSIN3genetic
20093466
TIR4_YEASTTIR4genetic
20093466
COX10_YEASTCOX10genetic
20093466
CSN12_YEASTYJR084Wgenetic
27708008
INO4_YEASTINO4genetic
27708008
MDM10_YEASTMDM10genetic
27708008
TREB_YEASTNTH2genetic
27708008
QOR_YEASTZTA1genetic
27708008
YPQ3_YEASTRTC2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CP56_YEASTDIT2genetic
27708008
UBP3_YEASTUBP3genetic
27708008
MED5_YEASTNUT1genetic
27708008
MED20_YEASTSRB2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
CYT2_YEASTCYT2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
EAF7_YEASTEAF7genetic
27708008
PSR2_YEASTPSR2genetic
26862728
HFA1_YEASTHFA1genetic
27453043
SAHH_YEASTSAH1genetic
27453043
CTK2_YEASTCTK2genetic
27453043
DCAM_YEASTSPE2genetic
27453043
GCR2_YEASTGCR2genetic
27453043
DCOR_YEASTSPE1genetic
27453043
SCH9_YEASTSCH9genetic
27453043
AAKG_YEASTSNF4genetic
27453043
RTG1_YEASTRTG1genetic
27453043
INO4_YEASTINO4genetic
27453043
INO2_YEASTINO2genetic
27453043
CLA4_YEASTCLA4genetic
27453043
ATC1_YEASTPMR1genetic
27453043
PHO85_YEASTPHO85genetic
27453043
NUP1_YEASTNUP1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSR1_YEAST

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Psr1p/Psr2p, two plasma membrane phosphatases with an essentialDXDX(T/V) motif required for sodium stress response in yeast.";
Siniossoglou S., Hurt E.C., Pelham H.R.B.;
J. Biol. Chem. 275:19352-19360(2000).
Cited for: FUNCTION, SUBCELLULAR LOCATION, POSSIBLE PALMITOYLATION,PHOSPHORYLATION, AND MUTAGENESIS OF GLY-2; 9-CYS-CYS-10; ASP-263 ANDASP-265.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-191, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND MASSSPECTROMETRY.

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