PLB3_YEAST - dbPTM
PLB3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLB3_YEAST
UniProt AC Q08108
Protein Name Lysophospholipase 3
Gene Name PLB3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 686
Subcellular Localization Cell membrane
Lipid-anchor, GPI-anchor .
Protein Description Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate..
Protein Sequence MIRPLCSKIIISYIFAISQFLLAANAWSPTDSYVPGTVSCPDDINLVREATSISQNESAWLEKRNKVTSVALKDFLTRATANFSDSSEVLSKLFNDGNSENLPKIAVAVSGGGYRSMLTGAGVLAAMDNRTEGAYEHGLGGLLQSTTYLSGASGGNWLVGTLALNNWTSVQDILNNMQNDDSIWDLSDSIVTPGGINIFKTAKRWDHISNAVESKQNADYNTSLADIWGRALAYNFFPSLNRGGIGLTWSSIRDFPVFQNAEMPFPISVADGRYPGTKVINLNATVFEFNPFEMGSWDPSLNSFANVKYLGTNVSNGVPLERGKCTAGFDNAGFIMGTSSTLFNQFLLRINSTHLPSFITRLARHFLKDLSQDFNDIAVYSPNPFKDTKFLDSDYTTSIVDSDSLFLVDGGEDDENVPVLPLIQKERDVDIIFAVDNSADMRLAWPDGSSLVHTYERQFVKQGQGMSFPYVPDTNTFVNLGLNKKPTFFGCDANNLTDLQYIPPLVVYLPNAEYSFNSNQSAFKLSYSESQRRSMIQNGFEIATRNNFTDDPEFMGCVGCAIIRRKQQALNITLPPECETCFKNYCWNGTLDTTPLPDVEKDVHHSFINVNSFNSSIGQEESLYAGSSASQSSSSSSSSSSSSEIPSATATLEKKAATNSGSHLSGISVKFSAMIMLTLLMFTGAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56N-linked_GlycosylationEATSISQNESAWLEK
HHHHCCCCHHHHHHH		38.10-
69PhosphorylationEKRNKVTSVALKDFL
HHHCCCHHHHHHHHH		14.3730377154
82N-linked_GlycosylationFLTRATANFSDSSEV
HHHHHHCCCCCHHHH		32.38-
129N-linked_GlycosylationGVLAAMDNRTEGAYE
HHHHHHCCCCCCHHH		39.42-
166N-linked_GlycosylationVGTLALNNWTSVQDI
EEEEEECCCCCHHHH		44.23-
221N-linked_GlycosylationSKQNADYNTSLADIW
HHHCCCCCCCHHHHH		24.60-
283N-linked_GlycosylationGTKVINLNATVFEFN
CCEEEECCCEEEEEC		29.13-
313N-linked_GlycosylationNVKYLGTNVSNGVPL
CCEECEECCCCCCCC		33.16-
351N-linked_GlycosylationNQFLLRINSTHLPSF
HHHHHHHHCCCHHHH		34.13-
495N-linked_GlycosylationFFGCDANNLTDLQYI
EECCCCCCCCCCCCC		46.14-
519N-linked_GlycosylationAEYSFNSNQSAFKLS
CEEECCCCCCCEECC		40.71-
547N-linked_GlycosylationFEIATRNNFTDDPEF
CEECCCCCCCCCHHH		37.59-
571N-linked_GlycosylationRRKQQALNITLPPEC
HHHHHHHCCCCCCCH		28.37-
588N-linked_GlycosylationCFKNYCWNGTLDTTP
HCCCCCCCCCCCCCC		29.97-
614N-linked_GlycosylationFINVNSFNSSIGQEE
CEECCCCCCCCCCCC		34.37-
659GPI-anchorLEKKAATNSGSHLSG
EEHHHHCCCCCCCCC		39.38-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLB3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLB3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLB3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLB2_YEASTPLB2genetic
10497163
YAP4_YEASTCIN5genetic
19269370
CSK2C_YEASTCKB2genetic
19269370
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
PP2C4_YEASTPTC4genetic
20093466
CHK1_YEASTCHK1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
PEX19_YEASTPEX19genetic
20093466
RRP8_YEASTRRP8genetic
20093466
VBA4_YEASTVBA4genetic
20093466
CWC15_YEASTCWC15genetic
20093466
GNTK_YEASTYDR248Cgenetic
20093466
DIN7_YEASTDIN7genetic
20093466
BCS1_YEASTBCS1genetic
20093466
PUF6_YEASTPUF6genetic
20093466
MSRA_YEASTMXR1genetic
20093466
SGF73_YEASTSGF73genetic
20093466
PYC1_YEASTPYC1genetic
20093466
STF2_YEASTSTF2genetic
20093466
RS25A_YEASTRPS25Agenetic
20093466
TPC1_YEASTTPC1genetic
20093466
PIH1_YEASTPIH1genetic
20093466
INM1_YEASTINM1genetic
20093466
CRP1_YEASTCRP1genetic
20093466
PEX18_YEASTPEX18genetic
20093466
NACA_YEASTEGD2genetic
20093466
IMA5_YEASTIMA5genetic
20093466
SMA2_YEASTSMA2genetic
20093466
AIM44_YEASTAIM44genetic
20093466
LGE1_YEASTLGE1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
WHI2_YEASTWHI2genetic
20526336
ROD1_YEASTROD1genetic
20526336
RSB1_YEASTRSB1genetic
20526336
ERG2_YEASTERG2genetic
21623372
HFA1_YEASTHFA1genetic
21623372
CHK1_YEASTCHK1genetic
22282571
THRC_YEASTTHR4genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
NU170_YEASTNUP170genetic
27708008
PP2C4_YEASTPTC4genetic
27708008
CHK1_YEASTCHK1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RRP8_YEASTRRP8genetic
27708008
CWC15_YEASTCWC15genetic
27708008
LIC4_YEASTATC1genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
PUF6_YEASTPUF6genetic
27708008
MSRA_YEASTMXR1genetic
27708008
PT122_YEASTPET122genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
PYC1_YEASTPYC1genetic
27708008
SGF73_YEASTSGF73genetic
27708008
MDM34_YEASTMDM34genetic
27708008
STF2_YEASTSTF2genetic
27708008
ASK10_YEASTASK10genetic
27708008
TRS65_YEASTTRS65genetic
27708008
UBR1_YEASTUBR1genetic
27708008
ELP2_YEASTELP2genetic
27708008
INM1_YEASTINM1genetic
27708008
IMA5_YEASTIMA5genetic
27708008
MDM35_YEASTMDM35genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
AVL9_YEASTAVL9genetic
27708008
MMS22_YEASTMMS22genetic
27708008
UBX2_YEASTUBX2genetic
27708008
MAC1_YEASTMAC1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
HAP5_YEASTHAP5genetic
27708008
LGE1_YEASTLGE1genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLB3_YEAST

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Related Literatures of Post-Translational Modification

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