dbPTM

STF2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STF2_YEAST
UniProt AC	P16965
Protein Name	ATPase-stabilizing factor 15 kDa protein
Gene Name	STF2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	84
Subcellular Localization	Mitochondrion.
Protein Description	This is one of two stabilizing factors of the inactive mitochondrial F0F1-ATPase. It binds to the F0 part and facilitates the binding of both the inhibitor and the 9 kDa protein to F1..
Protein Sequence	MTRTNKWTEREGKADPKYFSHTGNYGESPNHIKKQGSGKGNWGKPGDEIDDLIDNGEIPPVFKKDRRGSNLQSHEQKFENVQKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MTRTNKWTEREGK --CCCCCCCCCCCCC	55.68	25381059
17	Acetylation	REGKADPKYFSHTGN CCCCCCCCCCCCCCC	60.52	24489116
18	Phosphorylation	EGKADPKYFSHTGNY CCCCCCCCCCCCCCC	18.72	22369663
20	Phosphorylation	KADPKYFSHTGNYGE CCCCCCCCCCCCCCC	19.63	22369663
22	Phosphorylation	DPKYFSHTGNYGESP CCCCCCCCCCCCCCC	26.40	22369663
25	Phosphorylation	YFSHTGNYGESPNHI CCCCCCCCCCCCCCC	24.50	22369663
28	Phosphorylation	HTGNYGESPNHIKKQ CCCCCCCCCCCCCCC	27.00	22369663
33	Acetylation	GESPNHIKKQGSGKG CCCCCCCCCCCCCCC	31.34	22865919
37	Phosphorylation	NHIKKQGSGKGNWGK CCCCCCCCCCCCCCC	34.53	19779198
69	Phosphorylation	FKKDRRGSNLQSHEQ CCCCCCCCCCHHHHH	32.33	22369663
73	Phosphorylation	RRGSNLQSHEQKFEN CCCCCCHHHHHHHHH	31.96	22369663
77	Acetylation	NLQSHEQKFENVQKE CCHHHHHHHHHHHCC	52.22	24489116
83	Acetylation	QKFENVQKE------ HHHHHHHCC------	62.19	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STF2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STF2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STF2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD25_YEAST	SSL2	physical	18467557
MCFS2_YEAST	EHT1	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
ENV10_YEAST	ENV10	genetic	27708008
SIW14_YEAST	SIW14	genetic	27708008
TCB1_YEAST	TCB1	genetic	27708008
SUCA_YEAST	LSC1	genetic	27708008
RRM3_YEAST	RRM3	genetic	27708008
RL37A_YEAST	RPL37A	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
MSN1_YEAST	MSN1	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
AP1M1_YEAST	APM1	genetic	27708008
YMC1_YEAST	YMC1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STF2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-69, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-69 AND SER-73,AND MASS SPECTROMETRY.	17287358 [Abstract]
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.	11875433 [Abstract]