| UniProt ID | AP1M1_YEAST | |
|---|---|---|
| UniProt AC | Q00776 | |
| Protein Name | AP-1 complex subunit mu-1-I | |
| Gene Name | APM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 475 | |
| Subcellular Localization |
Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. Membrane, clathrin-coated pit Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin. AP57 is probably a subunit of the Golgi membrane adaptor.. | |
| Protein Sequence | MASAVYFCDHNGKPLLSRRYRDDIPLSAIDKFPILLSDLEEQSNLIPPCLNHNGLEYLFIQHNDLYVVAIVTSLSANAAAIFTFLHKLVEVLSDYLKTVEEESIRDNFVIIYELLDEVMDYGIPQITETKMLKQYITQKSFKLVKSAKKKRNATRPPVALTNSVSWRPEGITHKKNEAFLDIVESINMLMTQKGQVLRSEIIGDVKVNSKLSGMPDLKLGINDKGIFSKYLDDDTNIPSASATTSDNNTETDKKPSITSSSATNKKKVNIELEDLKFHQCVRLSKFENEKIITFIPPDGKFDLMNYRLSTTIKPLIWCDVNVQVHSNSRIEIHCKAKAQIKRKSTATNVEILIPVPDDADTPTFKYSHGSLKYVPEKSAILWKIRSFPGGKEYSMSAELGLPSISNNEDGNRTMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKINEPKLQYKSYPWVRYITQSGDDYTIRLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 161 | Phosphorylation | TRPPVALTNSVSWRP CCCCEEEECCCCCCC | 18.73 | 21440633 | |
| 163 | Phosphorylation | PPVALTNSVSWRPEG CCEEEECCCCCCCCC | 16.58 | 28889911 | |
| 165 | Phosphorylation | VALTNSVSWRPEGIT EEEECCCCCCCCCCC | 19.72 | 26447709 | |
| 172 | Phosphorylation | SWRPEGITHKKNEAF CCCCCCCCCCCCHHH | 38.20 | 26447709 | |
| 239 | Phosphorylation | DDDTNIPSASATTSD CCCCCCCCCCCCCCC | 30.93 | 21440633 | |
| 243 | Phosphorylation | NIPSASATTSDNNTE CCCCCCCCCCCCCCC | 25.08 | 24961812 | |
| 244 | Phosphorylation | IPSASATTSDNNTET CCCCCCCCCCCCCCC | 33.52 | 29734811 | |
| 245 | Phosphorylation | PSASATTSDNNTETD CCCCCCCCCCCCCCC | 33.70 | 21440633 | |
| 249 | Phosphorylation | ATTSDNNTETDKKPS CCCCCCCCCCCCCCC | 46.66 | 23749301 | |
| 251 | Phosphorylation | TSDNNTETDKKPSIT CCCCCCCCCCCCCCC | 51.59 | 24961812 | |
| 253 | Ubiquitination | DNNTETDKKPSITSS CCCCCCCCCCCCCCC | 74.20 | 23749301 | |
| 254 | Ubiquitination | NNTETDKKPSITSSS CCCCCCCCCCCCCCC | 46.97 | 23749301 | |
| 256 | Phosphorylation | TETDKKPSITSSSAT CCCCCCCCCCCCCCC | 47.59 | 24961812 | |
| 258 | Phosphorylation | TDKKPSITSSSATNK CCCCCCCCCCCCCCC | 27.22 | 27214570 | |
| 259 | Phosphorylation | DKKPSITSSSATNKK CCCCCCCCCCCCCCC | 22.18 | 27214570 | |
| 260 | Phosphorylation | KKPSITSSSATNKKK CCCCCCCCCCCCCCE | 18.49 | 24961812 | |
| 261 | Phosphorylation | KPSITSSSATNKKKV CCCCCCCCCCCCCEE | 38.59 | 24961812 | |
| 263 | Phosphorylation | SITSSSATNKKKVNI CCCCCCCCCCCEECE | 49.90 | 21440633 | |
| 311 | Phosphorylation | MNYRLSTTIKPLIWC CCEECCCEECCEEEE | 24.51 | 21551504 | |
| 383 | Acetylation | EKSAILWKIRSFPGG CCEEEEEEEECCCCC | 25.46 | 24489116 | |
| 393 | Phosphorylation | SFPGGKEYSMSAELG CCCCCCEEEEEEEEC | 17.10 | 29688323 | |
| 394 | Phosphorylation | FPGGKEYSMSAELGL CCCCCEEEEEEEECC | 13.83 | 29688323 | |
| 396 | Phosphorylation | GGKEYSMSAELGLPS CCCEEEEEEEECCCC | 16.79 | 29688323 | |
| 403 | Phosphorylation | SAELGLPSISNNEDG EEEECCCCCCCCCCC | 43.63 | 29688323 | |
| 405 | Phosphorylation | ELGLPSISNNEDGNR EECCCCCCCCCCCCC | 37.63 | 29688323 | |
| 413 | Phosphorylation | NNEDGNRTMPKSNAE CCCCCCCCCCCCCCH | 41.65 | 29688323 | |
| 454 | Phosphorylation | INEPKLQYKSYPWVR ECCCCCCCCCCCCEE | 16.61 | 19795423 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AP1M1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AP1M1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AP1M1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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