UFD4_YEAST - dbPTM
UFD4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UFD4_YEAST
UniProt AC P33202
Protein Name Ubiquitin fusion degradation protein 4
Gene Name UFD4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1483
Subcellular Localization
Protein Description E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
Protein Sequence MSENNSHNLDEHESHSENSDYMMDTQVEDDYDEDGHVQGEYSYYPDEDEDEHMLSSVGSFEADDGEDDDNDYHHEDDSGLLYGYHRTQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFKTIVEVLPTLKPIFSNATDQPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPKKISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFLLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87PhosphorylationLLYGYHRTQNGSDED
CEEEEEECCCCCCCC		17.0519795423
91PhosphorylationYHRTQNGSDEDRNEE
EEECCCCCCCCCCCC		45.4321082442
105PhosphorylationEEDGLERSHDNNEFG
CCCCCCCCCCCCCCC		26.3121440633
113PhosphorylationHDNNEFGSNPLHLPD
CCCCCCCCCCCCHHH		40.3619779198
135PhosphorylationRLEQRRQTSEGLGQH
HHHHHHHHCCCCCCC		27.2517330950
136PhosphorylationLEQRRQTSEGLGQHP
HHHHHHHCCCCCCCC		22.7129136822
174UbiquitinationARNERISKLIENTGN
HHHHHHHHHHHHCCC		51.6323749301
194UbiquitinationYIAMESLKELSENIL
HHHHHHHHHHHHHHH		66.9217644757
197PhosphorylationMESLKELSENILMMN
HHHHHHHHHHHHHHC		29.6829688323
339UbiquitinationSIRTDDFKTIVEVLP
HCCCCCHHHHHHHHH		44.3217644757
349UbiquitinationVEVLPTLKPIFSNAT
HHHHHHCCCHHCCCC		38.2522106047
682PhosphorylationISIHIFRTLSLAYIK
EEEEEEEHHHHHHHH		15.2228889911
684PhosphorylationIHIFRTLSLAYIKNK
EEEEEHHHHHHHHCC		15.4428889911
687PhosphorylationFRTLSLAYIKNKGVN
EEHHHHHHHHCCCHH		20.0928889911
785UbiquitinationVSHFILAKSFLEVFE
HHHHHHHHHHHHHHH		37.9917644757
943AcetylationVRRNRDLKTLWDDTH
HHCCCCCCHHCCCHH		45.9524489116
1421AcetylationKLPIGGFKSLNPKFT
CCCCCCCCCCCCCEE		58.2624489116
1455UbiquitinationMTCANYLKLPKYTSK
HHHHHHHCCCCCCCH		53.0022817900
1458UbiquitinationANYLKLPKYTSKDIM
HHHHCCCCCCCHHHH		72.1522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UFD4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UFD4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UFD4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PSA4_YEASTPRE6physical
12447385
PRS8_YEASTRPT6physical
12447385
PRS8_YEASTRPT6physical
10688918
RPN1_YEASTRPN1physical
10688918
ATC3_YEASTDRS2physical
16554755
ACON_YEASTACO1physical
16554755
KIN4_YEASTKIN4physical
16554755
LYS12_YEASTLYS12physical
16429126
AHA1_YEASTAHA1physical
16429126
TCPQ_YEASTCCT8physical
16429126
TBA1_YEASTTUB1physical
16429126
RSSA1_YEASTRPS0Aphysical
16429126
G3P2_YEASTTDH2physical
16429126
TBB_YEASTTUB2physical
16429126
PYR1_YEASTURA2physical
16429126
ILV6_YEASTILV6physical
16429126
LSM6_YEASTLSM6genetic
17314980
SLX8_YEASTSLX8genetic
17314980
RPA34_YEASTRPA34genetic
17314980
MED5_YEASTNUT1genetic
17314980
T2FB_YEASTTFG2genetic
17314980
ODO2_YEASTKGD2physical
11283351
TPO1_YEASTTPO1physical
18467557
UBR1_YEASTUBR1genetic
19164530
DMA1_YEASTDMA1genetic
20351217
DMA2_YEASTDMA2genetic
20351217
UBR1_YEASTUBR1physical
21076411
DOP1_YEASTDOP1genetic
21987634
GET1_YEASTGET1genetic
21987634
UBX2_YEASTUBX2genetic
21987634
MGMT_YEASTMGT1physical
21076411
UBC4_YEASTUBC4physical
21076411
UBI4P_YEASTUBI4physical
10089879
UBC4_YEASTUBC4physical
10089879
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
CISY2_YEASTCIT2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RTG3_YEASTRTG3genetic
27708008
YCR3_YEASTYCR023Cgenetic
27708008
ABP1_YEASTABP1genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
VAM6_YEASTVAM6genetic
27708008
PPB_YEASTPHO8genetic
27708008
STL1_YEASTSTL1genetic
27708008
GIP2_YEASTGIP2genetic
27708008
GEP7_YEASTGEP7genetic
27708008
STF2_YEASTSTF2genetic
27708008
MED20_YEASTSRB2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
LPLA_YEASTAIM22genetic
27708008
IF4A_YEASTTIF2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
DAN1_YEASTDAN1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
HMDH1_YEASTHMG1genetic
27708008
ERG5_YEASTERG5genetic
27708008
YET2_YEASTYET2genetic
27708008
UBX4_YEASTUBX4genetic
27708008
COX7_YEASTCOX7genetic
27708008
LSM7_YEASTLSM7genetic
27708008
MSN1_YEASTMSN1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
RAD1_YEASTRAD1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
COX10_YEASTCOX10genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RAD25_YEASTSSL2physical
25670855
UBI4P_YEASTUBI4physical
28165462
ELO2_YEASTELO2genetic
29674565
CHO2_YEASTCHO2genetic
29674565
RPN10_YEASTRPN10genetic
29674565
PAN1_YEASTPAN1genetic
29674565
COG3_YEASTCOG3genetic
29674565
NAB3_YEASTNAB3genetic
29674565
SNT1_YEASTSNT1genetic
29674565
SLX5_YEASTSLX5genetic
29674565
RS16A_YEASTRPS16Bgenetic
29674565
RS16B_YEASTRPS16Bgenetic
29674565
TRS23_YEASTTRS23genetic
29674565
SUM1_YEASTSUM1genetic
29674565
HOS2_YEASTHOS2genetic
29674565
SSL1_YEASTSSL1genetic
29674565
RPC1_YEASTRPO31genetic
29674565
LEO1_YEASTLEO1genetic
29674565
BEM4_YEASTBEM4genetic
29674565
MAK16_YEASTMAK16genetic
29674565
RXT2_YEASTRXT2genetic
29674565
RV161_YEASTRVS161genetic
29674565
RAD55_YEASTRAD55genetic
29674565
TCPZ_YEASTCCT6genetic
29674565
ACT_YEASTACT1genetic
29674565
GCN1_YEASTGCN1genetic
29674565
SKI8_YEASTSKI8genetic
29674565
DAM1_YEASTDAM1genetic
29674565
RGI2_YEASTRGI2genetic
29674565
SDS3_YEASTSDS3genetic
29674565
DENR_YEASTTMA22genetic
29674565
LST4_YEASTLST4genetic
29674565
VRP1_YEASTVRP1genetic
29674565
GAS1_YEASTGAS1genetic
29674565
CAP_YEASTSRV2genetic
29674565
SEC12_YEASTSEC12genetic
29674565
SKI3_YEASTSKI3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UFD4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91 AND THR-135, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, AND MASSSPECTROMETRY.

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