dbPTM

RAD1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAD1_YEAST
UniProt AC	P06777
Protein Name	DNA repair protein RAD1
Gene Name	RAD1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1100
Subcellular Localization	Nucleus.
Protein Description	Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD10 forms an endonuclease that specifically degrades single-stranded DNA..
Protein Sequence	MSQLFYQGDSDDELQEELTRQTTQASQSSKIKNEDEPDDSNHLNEVENEDSKVLDDDAVLYPLIPNEPDDIETSKPNINDIRPVDIQLTLPLPFQQKVVENSLITEDALIIMGKGLGLLDIVANLLHVLATPTSINGQLKRALVLVLNAKPIDNVRIKEALEELSWFSNTGKDDDDTAVESDDELFERPFNVVTADSLSIEKRRKLYISGGILSITSRILIVDLLSGIVHPNRVTGMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPETFVMEFSPLRTKMKELRLKNVLLWPRFRVEVSSCLNATNKTSHNKVIEVKVSLTNSMSQIQFGLMECLKKCIAELSRKNPELALDWWNMENVLDINFIRSIDSVMVPNWHRISYESKQLVKDIRFLRHLLKMLVTSDAVDFFGEIQLSLDANKPSVSRKYSESPWLLVDEAQLVISYAKKRIFYKNEYTLEENPKWEQLIHILHDISHERMTNHLQGPTLVACSDNLTCLELAKVLNASNKKRGVRQVLLNKLKWYRKQREETKKLVKEVQSQDTFPENATLNVSSTFSKEQVTTKRRRTRGASQVAAVEKLRNAGTNVDMEVVFEDHKLSEEIKKGSGDDLDDGQEENAANDSKIFEIQEQENEILIDDGDAEFDNGELEYVGDLPQHITTHFNKDLWAEHCNEYEYVDRQDEILISTFKSLNDNCSLQEMMPSYIIMFEPDISFIRQIEVYKAIVKDLQPKVYFMYYGESIEEQSHLTAIKREKDAFTKLIRENANLSHHFETNEDLSHYKNLAERKLKLSKLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVGDYVITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLEPFSERRNYKNKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGREQPDPSNAVILGTNKVRSDFNSTAKGLKDGDNESKFKRLLNVPGVSKIDYFNLRKKIKSFNKLQKLSWNEINELINDEDLTDRIYYFLRTEKEEQEQESTDENLESPGKTTDDNALHDHHNDVPEAPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQLFYQGD ------CCCCCCCCC	47.06	30377154
6	Phosphorylation	--MSQLFYQGDSDDE --CCCCCCCCCCCHH	21.85	30377154
10	Phosphorylation	QLFYQGDSDDELQEE CCCCCCCCCHHHHHH	54.51	28152593
26	Phosphorylation	TRQTTQASQSSKIKN HHHHHHHHHHHCCCC	22.30	27214570
40	Phosphorylation	NEDEPDDSNHLNEVE CCCCCCCCCCHHHHC	33.26	25704821
51	Phosphorylation	NEVENEDSKVLDDDA HHHCCCCCCCCCCCC	20.63	28889911
181	Phosphorylation	DDDTAVESDDELFER CCCCCCCCCHHHHHC	43.70	28889911
592	Phosphorylation	EKLRNAGTNVDMEVV HHHHHCCCCCCEEEE	29.65	28889911
613	Phosphorylation	SEEIKKGSGDDLDDG HHHHHCCCCCCCCCC	48.18	23749301
629	Phosphorylation	EENAANDSKIFEIQE CCCCCCCCCCEEEHH	27.71	21551504
1062	Phosphorylation	RIYYFLRTEKEEQEQ HHHHHHHCHHHHHHH	54.26	30377154
1071	Phosphorylation	KEEQEQESTDENLES HHHHHHHCCCCCCCC	40.63	17563356
1072	Phosphorylation	EEQEQESTDENLESP HHHHHHCCCCCCCCC	46.72	17563356
1078	Phosphorylation	STDENLESPGKTTDD CCCCCCCCCCCCCCC	41.96	21551504

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAD1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAD1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAD1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAW1_YEAST	SAW1	physical	11805837
SEN1_YEAST	SEN1	physical	11805837
LSP1_YEAST	LSP1	physical	11805837
SEC6_YEAST	SEC6	physical	11805837
YHJ3_YEAST	YHR033W	physical	11805837
STE20_YEAST	STE20	physical	11805837
GPD2_YEAST	GPD2	physical	11805837
DMA2_YEAST	DMA2	physical	11805837
MDM30_YEAST	MDM30	physical	11805837
GPD1_YEAST	GPD1	physical	11805837
DUN1_YEAST	DUN1	physical	11805837
FAR1_YEAST	FAR1	physical	11805837
PIL1_YEAST	PIL1	physical	11805837
UBI4P_YEAST	UBI4	physical	11805837
OAT_YEAST	CAR2	physical	11805837
PDC6_YEAST	PDC6	physical	11805837
MSI1_YEAST	MSI1	physical	11805837
UTP4_YEAST	UTP4	physical	11805837
RAD10_YEAST	RAD10	physical	8621533
RAD14_YEAST	RAD14	physical	8621533
RAD10_YEAST	RAD10	physical	1620114
RAD10_YEAST	RAD10	physical	1518857
RAD10_YEAST	RAD10	physical	8479526
RAD10_YEAST	RAD10	physical	8172904
RAD10_YEAST	RAD10	physical	8361362
RAD10_YEAST	RAD10	physical	8253764
RAD10_YEAST	RAD10	physical	8702799
RAD10_YEAST	RAD10	genetic	8407807
TYDP1_YEAST	TDP1	genetic	12368472
KU70_YEAST	YKU70	genetic	12101230
MRE11_YEAST	MRE11	genetic	12101230
UBC2_YEAST	RAD6	genetic	11890933
RAD51_YEAST	RAD51	genetic	11094068
RAD52_YEAST	RAD52	genetic	10430580
RAD52_YEAST	RAD52	genetic	8849883
RAD52_YEAST	RAD52	genetic	7862154
RAD52_YEAST	RAD52	genetic	2693208
RAD52_YEAST	RAD52	genetic	2227387
TOP3_YEAST	TOP3	genetic	1328869
SGS1_YEAST	SGS1	genetic	11290710
SRS2_YEAST	SRS2	genetic	11290710
APN1_YEAST	APN1	genetic	14585995
FEN1_YEAST	RAD27	genetic	9837987
DPOD3_YEAST	POL32	genetic	11973297
DPOZ_YEAST	REV3	genetic	11973297
RFA1_YEAST	RFA1	genetic	7862154
RAD52_YEAST	RAD52	genetic	8070653
RAD51_YEAST	RAD51	genetic	7705645
RAD59_YEAST	RAD59	genetic	14704162
RAD18_YEAST	RAD18	genetic	9725831
UBC2_YEAST	RAD6	genetic	9725831
EXO1_YEAST	EXO1	genetic	10628975
MSH6_YEAST	MSH6	genetic	10628975
PMS1_YEAST	PMS1	genetic	10628975
MAG_YEAST	MAG1	genetic	9506896
APN1_YEAST	APN1	genetic	9506896
MMS2_YEAST	MMS2	genetic	15687278
DPOZ_YEAST	REV3	genetic	15687278
DPOD3_YEAST	POL32	genetic	15687278
SRS2_YEAST	SRS2	genetic	15687278
ATR_YEAST	MEC1	genetic	15687264
ELG1_YEAST	ELG1	genetic	15687264
RAD5_YEAST	RAD5	genetic	15687264
RAD18_YEAST	RAD18	genetic	15687264
MRE11_YEAST	MRE11	genetic	15687264
RAD52_YEAST	RAD52	genetic	15687264
RFA1_YEAST	RFA1	genetic	15687264
FEN1_YEAST	RAD27	genetic	15687264
MUS81_YEAST	MUS81	genetic	15687264
YC16_YEAST	YCR087C-A	physical	16554755
FIMB_YEAST	SAC6	physical	16554755
YRA1_YEAST	YRA1	physical	16554755
EF2_YEAST	EFT2	physical	16554755
RV167_YEAST	RVS167	physical	16554755
ARP3_YEAST	ARP3	physical	16554755
CORO_YEAST	CRN1	physical	16554755
NOP53_YEAST	NOP53	physical	16554755
WDR6_YEAST	RTT10	physical	16554755
RAD14_YEAST	RAD14	physical	16428464
APN1_YEAST	APN1	genetic	16793364
APN2_YEAST	APN2	genetic	16793364
RAD18_YEAST	RAD18	genetic	17314980
SSN8_YEAST	SSN8	genetic	17314980
SWI3_YEAST	SWI3	genetic	17314980
APN1_YEAST	APN1	genetic	17314980
DOA1_YEAST	DOA1	genetic	17314980
CIK1_YEAST	CIK1	genetic	17314980
AHC1_YEAST	AHC1	genetic	17314980
SGS1_YEAST	SGS1	genetic	17314980
RAD5_YEAST	RAD5	genetic	17314980
SUS1_YEAST	SUS1	genetic	17314980
GCN1_YEAST	GCN1	genetic	17314980
RSC1_YEAST	RSC1	genetic	17314980
APQ12_YEAST	APQ12	genetic	17314980
PCNA_YEAST	POL30	genetic	17314980
SPT2_YEAST	SPT2	genetic	17314980
SLX4_YEAST	SLX4	physical	11283351
SGS1_YEAST	SGS1	genetic	17399687
RLF2_YEAST	RLF2	genetic	17267293
RAD18_YEAST	RAD18	genetic	17267293
RAD10_YEAST	RAD10	physical	17636031
RAD52_YEAST	RAD52	genetic	16428464
RAD52_YEAST	RAD52	genetic	3065620
RAD52_YEAST	RAD52	genetic	14612421
RAD52_YEAST	RAD52	genetic	9927442
NSE1_YEAST	NSE1	genetic	17923688
RAD51_YEAST	RAD51	genetic	17785441
RAD52_YEAST	RAD52	genetic	17785441
RAD54_YEAST	RAD54	genetic	17785441
RAD5_YEAST	RAD5	genetic	17785441
RAD50_YEAST	RAD50	genetic	17785441
XRS2_YEAST	XRS2	genetic	17785441
POLH_YEAST	RAD30	genetic	17442629
RAD51_YEAST	RAD51	genetic	18373960
RAD59_YEAST	RAD59	genetic	18373960
SAW1_YEAST	SAW1	physical	18471978
RAD10_YEAST	RAD10	physical	18719252
SLX4_YEAST	SLX4	physical	18719252
SSB2_YEAST	SSB2	physical	19536198
HSP72_YEAST	SSA2	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
DOT1_YEAST	DOT1	genetic	18562671
RAD9_YEAST	RAD9	genetic	18579504
SLX4_YEAST	SLX4	genetic	18579504
MAD2_YEAST	MAD2	genetic	18579504
MMS2_YEAST	MMS2	genetic	18579504
MPH1_YEAST	MPH1	genetic	18579504
RAD51_YEAST	RAD51	genetic	19553188
RAD50_YEAST	RAD50	genetic	19540258
NTH1_YEAST	NTG1	genetic	19540258
NTH2_YEAST	NTG2	genetic	19540258
APN1_YEAST	APN1	genetic	19540258
RAD59_YEAST	RAD59	genetic	20012294
RAD52_YEAST	RAD52	genetic	12368472
DNLI4_YEAST	DNL4	genetic	12368472
RAD2_YEAST	RAD2	genetic	12368472
SRS2_YEAST	SRS2	genetic	12368472
RAD59_YEAST	RAD59	genetic	12368472
RAD17_YEAST	RAD17	genetic	12368472
SGS1_YEAST	SGS1	genetic	12368472
MMS4_YEAST	MMS4	genetic	15687264
DPOZ_YEAST	REV3	genetic	8088509
RIR4_YEAST	RNR4	genetic	18400565
UNG_YEAST	UNG1	genetic	14585995
DUT_YEAST	DUT1	genetic	14585995
RAD52_YEAST	RAD52	genetic	12807766
DPOZ_YEAST	REV3	genetic	12807766
SWA2_YEAST	SWA2	genetic	20526336
SUR1_YEAST	SUR1	genetic	20526336
TPP1_YEAST	TPP1	genetic	12783866
APN2_YEAST	APN2	genetic	12783866
SLX1_YEAST	SLX1	genetic	22354996
DPOZ_YEAST	REV3	genetic	23090979
SAW1_YEAST	SAW1	physical	23299942
RAD10_YEAST	RAD10	physical	23299942
ATR_YEAST	MEC1	genetic	19540258
EXO1_YEAST	EXO1	genetic	19540258
CHK1_YEAST	CHK1	genetic	15687272
RAD9_YEAST	RAD9	genetic	15687272
DUN1_YEAST	DUN1	genetic	15687272
SML1_YEAST	SML1	genetic	15687272
RAD17_YEAST	RAD17	genetic	15687272
MEC3_YEAST	MEC3	genetic	15687272
DDC1_YEAST	DDC1	genetic	15687272
RAD24_YEAST	RAD24	genetic	15687272
RAD53_YEAST	RAD53	genetic	15687272
RT107_YEAST	RTT107	genetic	15687272
TOF1_YEAST	TOF1	genetic	15687272
MRC1_YEAST	MRC1	genetic	15687272
MAD2_YEAST	MAD2	genetic	15687272
SECU_YEAST	PDS1	genetic	15687272
UNG_YEAST	UNG1	genetic	15687272
YEN1_YEAST	YEN1	genetic	24119400
YEN1_YEAST	YEN1	genetic	24496010
MUS81_YEAST	MUS81	genetic	24496010
TYDP1_YEAST	TDP1	genetic	24753409
APN2_YEAST	APN2	genetic	24753409
RAD10_YEAST	RAD10	physical	24753409
RAD14_YEAST	RAD14	physical	24753409
SLX4_YEAST	SLX4	physical	24753409
SAW1_YEAST	SAW1	physical	24753409
SAW1_YEAST	SAW1	physical	25263559
RT107_YEAST	RTT107	genetic	26439300
CSG2_YEAST	CSG2	genetic	27708008
OMS1_YEAST	OMS1	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
AIM21_YEAST	AIM21	genetic	27708008
SIP4_YEAST	SIP4	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
DPH4_YEAST	JJJ3	genetic	27708008
MCM22_YEAST	MCM22	genetic	27708008
SPT23_YEAST	SPT23	genetic	27708008
NNRD_YEAST	YKL151C	genetic	27708008
KKQ8_YEAST	KKQ8	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
DOA1_YEAST	DOA1	genetic	27708008
RAD5_YEAST	RAD5	genetic	27708008
TOP3_YEAST	TOP3	genetic	27708008
NKP2_YEAST	NKP2	genetic	27708008
SGS1_YEAST	SGS1	genetic	27708008
RNH2A_YEAST	RNH201	genetic	26340535
RAD59_YEAST	RAD59	genetic	23824283
TOR2_YEAST	TOR2	genetic	27453043
DYR_YEAST	DFR1	genetic	27453043
CDC42_YEAST	CDC42	genetic	27453043
MRE11_YEAST	MRE11	genetic	27453043
DCOR_YEAST	SPE1	genetic	27453043
ASF1_YEAST	ASF1	genetic	27453043
TBG_YEAST	TUB4	genetic	27453043
ADE_YEAST	AAH1	genetic	27453043
HSC82_YEAST	HSC82	genetic	27453043
ERG1_YEAST	ERG1	genetic	27453043
DCAM_YEAST	SPE2	genetic	27453043
SAW1_YEAST	SAW1	physical	29660012
RAD10_YEAST	RAD10	physical	29660012
SAW1_YEAST	SAW1	genetic	29660012
MSH3_YEAST	MSH3	genetic	29660012
RFA1_YEAST	RFA1	physical	29660012

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAD1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1071 AND THR-1072, ANDMASS SPECTROMETRY.	17563356 [Abstract]