APN2_YEAST - dbPTM
APN2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APN2_YEAST
UniProt AC P38207
Protein Name DNA-(apurinic or apyrimidinic site) lyase 2
Gene Name APN2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 520
Subcellular Localization Nucleus.
Protein Description DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA..
Protein Sequence MSSSENTLLDGKSENTIRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFFRADIITFQELKTEKLSISKWGRVDGFYSFISIPQTRKGYSGVGCWIRIPEKNHPLYHALQVVKAEEGITGYLTIKNGKHSAISYRNDVNQGIGGYDSLDPDLDEKSALELDSEGRCVMVELACGIVIISVYCPANSNSSEEGEMFRLRFLKVLLRRVRNLDKIGKKIVLMGDVNVCRDLIDSADTLEQFSIPITDPMGGTKLEAQYRDKAIQFIINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLIQTRNRLKMYTVWNMLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDILGSDHCPVYSDLDILDDRIEPGTTQVPIPKFEARYKYNLRNHNVLEMFAKKDTNKESNKQKYCVSKVMNTKKNSNIKNKSLDSFFQKVNGEKDDRIKESSEIPQQAKKRISTPKLNFKDVFGKPPLCRHGEESMLKTSKTSANPGRKFWICKRSRGDSNNTESSCGFFQWV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
415AcetylationKQKYCVSKVMNTKKN
HHHHHHHHHHCCCCC		25.7125381059
429PhosphorylationNSNIKNKSLDSFFQK
CCCCCCCCHHHHHHH		46.9627214570
460PhosphorylationQQAKKRISTPKLNFK
HHHHHHCCCCCCCHH		42.5628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APN2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APN2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APN2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCNA_YEASTPOL30physical
12192046
RAD1_YEASTRAD1genetic
14585995
RAD52_YEASTRAD52genetic
11585902
MAG_YEASTMAG1genetic
14697759
RIM1_YEASTRIM1physical
16554755
PFD5_YEASTGIM5genetic
19547744
TPP1_YEASTTPP1genetic
19955329
MAG_YEASTMAG1genetic
11738940
DPOZ_YEASTREV3genetic
11738940
RAD10_YEASTRAD10genetic
15371342
RAD1_YEASTRAD1genetic
15371342
UNG_YEASTUNG1genetic
14585995
DUT_YEASTDUT1genetic
14585995
APTX_YEASTHNT3genetic
20399152
RAD1_YEASTRAD1genetic
12032096
RAD10_YEASTRAD10genetic
12032096
UNG_YEASTUNG1genetic
22226374
RAD9_YEASTRAD9genetic
22226374
ATR_YEASTMEC1genetic
22226374
SML1_YEASTSML1genetic
22226374
RAD53_YEASTRAD53genetic
22226374
RAD17_YEASTRAD17genetic
22226374
RAD24_YEASTRAD24genetic
22226374
DDC1_YEASTDDC1genetic
22226374
DPOZ_YEASTREV3genetic
22226374
RAD14_YEASTRAD14genetic
22226374
RAD51_YEASTRAD51genetic
22226374
MMS2_YEASTMMS2genetic
22226374
NTH1_YEASTNTG1genetic
22226374
NTH2_YEASTNTG2genetic
22226374
PCNA_YEASTPOL30physical
22308326
MED22_YEASTSRB6genetic
27708008
SEC18_YEASTSEC18genetic
27708008
APC11_YEASTAPC11genetic
27708008
FAD1_YEASTFAD1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
TIM22_YEASTTIM22genetic
27708008
GPI19_YEASTGPI19genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SMD1_YEASTSMD1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
MED6_YEASTMED6genetic
27708008
MET30_YEASTMET30genetic
27708008
OST1_YEASTOST1genetic
27708008
ARP4_YEASTARP4genetic
27708008
KRE9_YEASTKRE9genetic
27708008
SEC65_YEASTSEC65genetic
27708008
LIP1_YEASTLIP1genetic
27708008
SMP3_YEASTSMP3genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NTH1_YEASTNTG1genetic
27298254
NTH2_YEASTNTG2genetic
27298254
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APN2_YEAST

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