UNG_YEAST - dbPTM
UNG_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNG_YEAST
UniProt AC P12887
Protein Name Uracil-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_03166}
Gene Name UNG1 {ECO:0000255|HAMAP-Rule:MF_03166}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 359
Subcellular Localization Mitochondrion . Nucleus .
Protein Description Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Not involved in strand-directed mismatch repair..
Protein Sequence MWCMRRLPTNSVMTVARKRKQTTIEDFFGTKKSTNEAPNKKGKSGATFMTITNGAAIKTETKAVAKEANTDKYPANSNAKDVYSKNLSSNLRTLLSLELETIDDSWFPHLMDEFKKPYFVKLKQFVTKEQADHTVFPPAKDIYSWTRLTPFNKVKVVIIGQDPYHNFNQAHGLAFSVKPPTPAPPSLKNIYKELKQEYPDFVEDNKVGDLTHWASQGVLLLNTSLTVRAHNANSHSKHGWETFTKRVVQLLIQDREADGKSLVFLLWGNNAIKLVESLLGSTSVGSGSKYPNIMVMKSVHPSPLSASRGFFGTNHFKMINDWLYNTRGEKMIDWSVVPGTSLREVQEANARLESESKDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationVARKRKQTTIEDFFG
HHHHCCCCCHHHHHC		32.5424930733
30PhosphorylationTIEDFFGTKKSTNEA
CHHHHHCCCCCCCCC		30.0924930733
31AcetylationIEDFFGTKKSTNEAP
HHHHHCCCCCCCCCC		45.1425381059
40AcetylationSTNEAPNKKGKSGAT
CCCCCCCCCCCCCCE		62.9425381059
72AcetylationAKEANTDKYPANSNA
HHHHCCCCCCCCCCH		51.6124489116
93PhosphorylationNLSSNLRTLLSLELE
CCCHHHHHHHHCEEE		34.9128889911
105PhosphorylationELETIDDSWFPHLMD
EEEECCCCCCHHHHH		27.2028889911
215PhosphorylationGDLTHWASQGVLLLN
CHHHHHHHHCEEEEE		23.4423749301
223PhosphorylationQGVLLLNTSLTVRAH
HCEEEEEEEEEEEEE		25.6923749301
324PhosphorylationKMINDWLYNTRGEKM
HHHHHHHHCCCCCCC		15.3828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNG_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNG_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNG_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBF4_YEASTDBF4genetic
17314980
LRP1_YEASTLRP1genetic
17314980
BRE2_YEASTBRE2genetic
17314980
DEP1_YEASTDEP1genetic
17314980
UBR1_YEASTUBR1genetic
17314980
ARO1_YEASTARO1genetic
17314980
PRI1_YEASTPRI1genetic
17314980
ZRT1_YEASTZRT1genetic
20093466
ASK10_YEASTASK10genetic
20093466
SNF6_YEASTSNF6genetic
20093466
DCOR_YEASTSPE1genetic
20093466
PCNA_YEASTPOL30physical
22308326
ABC3G_HUMANAPOBEC3Ggenetic
23271983
PSB6_YEASTPRE7genetic
27708008
DPOD_YEASTPOL3genetic
27708008
ERF3_YEASTSUP35genetic
27708008
SNU56_YEASTSNU56genetic
27708008
GPI10_YEASTGPI10genetic
27708008
SPC97_YEASTSPC97genetic
27708008
NSE1_YEASTNSE1genetic
27708008
SDO1_YEASTSDO1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
TYSY_YEASTCDC21genetic
27708008
SMP3_YEASTSMP3genetic
27708008
DYR_YEASTDFR1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNG_YEAST

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Related Literatures of Post-Translational Modification

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