MSH3_YEAST - dbPTM
MSH3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSH3_YEAST
UniProt AC P25336
Protein Name DNA mismatch repair protein MSH3
Gene Name MSH3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1018
Subcellular Localization Nucleus .
Protein Description Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with either the MutL alpha or MutL beta heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination. MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail removal (NHTR). MutS beta-binding alters the DNA conformation of its substrate at the ds/ssDNA junction and may facilitate its recognition and/or cleavage by the downstream nucleotide excision repair (NER) RAD1-RAD10 endonuclease. ATP binding and hydrolysis play a pivotal role in MMR and NHTR..
Protein Sequence MAGQPTISRFFKKAVKSELTHKQEQEVAVGNGAGSESICLDTDEEDNLSSVASTTVTNDSFPLKGSVSSKNSKNSEKTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDEEEGEEDFVKKKARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVAKFFKDISCPLIHKQEYDLEDHVVQAIKVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQVMLIPSIYSPFASKIHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVYFYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLSTTQLPHFLTMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRPYLNFRDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNYVRPTFVNGQQAIIAKNARNPIIESLDVHYVPNDIMMSPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGEIKSPLIRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESINEDALKLFSSLKRILKSDNITATDKLAKLLSLDIH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16AcetylationRFFKKAVKSELTHKQ
HHHHHHHHHCCCCHH		42.9725381059
102PhosphorylationDRIMKRRSDENVEAE
HHHHHHCCCCCCCCC		54.0021551504
672AcetylationWIKVNNTKMVSRFTT
EEEECCCCEEECCCC		39.1525381059
728PhosphorylationITLNLAQYDCILSLA
HHHHHHHHHHHHHHH		13.7429136822
733PhosphorylationAQYDCILSLAATSCN
HHHHHHHHHHHCCCC		8.9629136822
737PhosphorylationCILSLAATSCNVNYV
HHHHHHHCCCCCCCC		28.3629136822
738PhosphorylationILSLAATSCNVNYVR
HHHHHHCCCCCCCCC		10.0429136822
743PhosphorylationATSCNVNYVRPTFVN
HCCCCCCCCCCCCCC		8.1129136822
747PhosphorylationNVNYVRPTFVNGQQA
CCCCCCCCCCCCEEE		29.6529136822
767PhosphorylationARNPIIESLDVHYVP
CCCCCCEEEEEEECC		21.3327017623
772PhosphorylationIESLDVHYVPNDIMM
CEEEEEEECCCCEEE		19.9027017623
780PhosphorylationVPNDIMMSPENGKIN
CCCCEEECCCCCCEE		16.2227017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSH3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSH3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSH3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B1_YEASTHTB1physical
11805837
BIOA_YEASTBIO3physical
11805837
RAD59_YEASTRAD59genetic
10866686
MSH6_YEASTMSH6genetic
10022887
RAD1_YEASTRAD1genetic
8849883
RAD52_YEASTRAD52genetic
8849883
DPOD_YEASTPOL3genetic
8844147
MSH6_YEASTMSH6genetic
8631743
MSH6_YEASTMSH6genetic
14704162
RAD59_YEASTRAD59genetic
14704162
RAD51_YEASTRAD51genetic
14704162
MSH6_YEASTMSH6genetic
9111356
MSH6_YEASTMSH6genetic
10628975
PMS1_YEASTPMS1genetic
10628975
MSH6_YEASTMSH6genetic
15177182
MSH2_YEASTMSH2physical
16429126
RFA1_YEASTRFA1physical
16429126
RFA3_YEASTRFA3physical
16429126
UBC4_YEASTUBC4genetic
17314980
MSH6_YEASTMSH6genetic
17157869
MSH6_YEASTMSH6genetic
10418148
MSH6_YEASTMSH6genetic
21726567
MSH6_YEASTMSH6genetic
22118461
MSH6_YEASTMSH6genetic
23307893
DPOE_YEASTPOL2genetic
23307893
MLH1_YEASTMLH1physical
24550389
PMS1_YEASTPMS1physical
24550389
MLH1_YEASTMLH1physical
24811092
PMS1_YEASTPMS1physical
24811092
MLH2_YEASTMLH2physical
24811092
MSH6_YEASTMSH6genetic
26224637
FEN1_YEASTRAD27genetic
26224637
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
CDC37_YEASTCDC37genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
HACD_YEASTPHS1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
BAP2_YEASTBAP2genetic
27708008
ARO1_YEASTARO1genetic
27708008
MSH4_YEASTMSH4genetic
27708008
WWM1_YEASTWWM1genetic
27708008
CBPS_YEASTCPS1genetic
27708008
MMR1_YEASTMMR1genetic
27708008
BUL2_YEASTBUL2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
BUL1_YEASTBUL1genetic
27708008
YP066_YEASTRGL1genetic
27708008
MLC2_YEASTMLC2genetic
27708008
TCO89_YEASTTCO89genetic
25302077
ULP2_YEASTULP2genetic
25302077
SCH9_YEASTSCH9genetic
25302077
ARP8_YEASTARP8genetic
25302077
NUP60_YEASTNUP60genetic
25302077
MRT4_YEASTMRT4genetic
25302077
SSU1_YEASTSSU1genetic
25302077
ULS1_YEASTULS1genetic
25302077
RBG1_YEASTRBG1genetic
25302077
ATG2_YEASTATG2genetic
25302077
SNF2_YEASTSNF2genetic
27453043
CDC42_YEASTCDC42genetic
27453043
CBF1_YEASTCBF1genetic
27453043
RAD1_YEASTRAD1physical
29660012
RAD10_YEASTRAD10physical
29660012
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSH3_YEAST

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Related Literatures of Post-Translational Modification

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