CBPS_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBPS_YEAST
• UniProt AC: P27614
• Protein Name: Carboxypeptidase S
• Gene Name: CPS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 576
• Subcellular Localization: Vacuole membrane ; Single-pass membrane protein . Lysosome-like vacuoles.
• Protein Description: Necessary for use of certain peptides as sole nitrogen source. May also cleave intracellularly generated peptides to recycle amino acids for protein synthesis..
• Protein Sequence: MIALPVEKAPRKSLWQRHRAFISGIVALIIIGTFFLTSGLHPAPPHEAKRPHHGKGPMHSPKCEKIEPLSPSFKHSVDTILHDPAFRNSSIEKLSNAVRIPTVVQDKNPNPADDPDFYKHFYELHDYFEKTFPNIHKHLKLEKVNELGLLYTWEGSDPDLKPLLLMAHQDVVPVNNETLSSWKFPPFSGHYDPETDFVWGRGSNDCKNLLIAEFEAIEQLLIDGFKPNRTIVMSLGFDEEASGTLGAASLASFLHERYGDDGIYSIIDEGEGIMEVDKDVFVATPINAEKGYVDFEVSILGHGGHSSVPPDHTTIGIASELITEFEANPFDYEFEFDNPIYGLLTCAAEHSKSLSKDVKKTILGAPFCPRRKDKLVEYISNQSHLRSLIRTTQAVDIINGGVKANALPETTRFLINHRINLHSSVAEVFERNIEYAKKIAEKYGYGLSKNGDDYIIPETELGHIDITLLRELEPAPLSPSSGPVWDILAGTIQDVFENGVLQNNEEFYVTTGLFSGNTDTKYYWNLSKNIYRFVGSIIDIDLLKTLHSVNEHVDVPGHLSAIAFVYEYIVNVNEYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MIALPVEKAPRKSLW CCCCCCCCCCCCCHH	65.02	22106047
65	Acetylation	MHSPKCEKIEPLSPS CCCCCCCCCCCCCHH	62.94	25381059
70	Phosphorylation	CEKIEPLSPSFKHSV CCCCCCCCHHHHCCH	29.25	24961812
72	Phosphorylation	KIEPLSPSFKHSVDT CCCCCCHHHHCCHHH	43.48	24961812
74	Ubiquitination	EPLSPSFKHSVDTIL CCCCHHHHCCHHHHH	39.03	24961812
88	N-linked_Glycosylation	LHDPAFRNSSIEKLS HCCHHHCCCHHHHHH	33.39	-
93	Ubiquitination	FRNSSIEKLSNAVRI HCCCHHHHHHHCCCC	56.39	17644757
102	Phosphorylation	SNAVRIPTVVQDKNP HHCCCCCCEECCCCC	30.82	22369663
107	Ubiquitination	IPTVVQDKNPNPADD CCCEECCCCCCCCCC	58.16	17644757
119	Ubiquitination	ADDPDFYKHFYELHD CCCHHHHHHHHHHHH	27.51	17644757
130	Ubiquitination	ELHDYFEKTFPNIHK HHHHHHHHHCCCHHH	45.63	17644757
176	N-linked_Glycosylation	QDVVPVNNETLSSWK CCEEECCCCCCCCCC	43.81	-
183	Ubiquitination	NETLSSWKFPPFSGH CCCCCCCCCCCCCCC	50.36	17644757
228	N-linked_Glycosylation	LIDGFKPNRTIVMSL HHCCCCCCCEEEEEE	55.08	-
278	Ubiquitination	EGIMEVDKDVFVATP CCCEEECCCEEEEEE	62.05	17644757
284	Phosphorylation	DKDVFVATPINAEKG CCCEEEEEECCCCCC	21.28	27017623
290	Ubiquitination	ATPINAEKGYVDFEV EEECCCCCCEEEEEE	53.80	17644757
359	Ubiquitination	KSLSKDVKKTILGAP HHCCHHHHHHHHCCC	55.09	17644757
360	Ubiquitination	SLSKDVKKTILGAPF HCCHHHHHHHHCCCC	40.42	17644757
372	Ubiquitination	APFCPRRKDKLVEYI CCCCCCCHHHHHHHH	61.57	17644757
374	Ubiquitination	FCPRRKDKLVEYISN CCCCCHHHHHHHHCC	58.42	17644757
374	Acetylation	FCPRRKDKLVEYISN CCCCCHHHHHHHHCC	58.42	24489116
381	N-linked_Glycosylation	KLVEYISNQSHLRSL HHHHHHCCHHHHHHH	37.50	-
387	Phosphorylation	SNQSHLRSLIRTTQA CCHHHHHHHHHHCCH	34.21	27017623
403	Ubiquitination	DIINGGVKANALPET HHHCCCCCCCCCCHH	38.92	17644757
410	Phosphorylation	KANALPETTRFLINH CCCCCCHHHHHHHHH	22.72	27017623
411	Phosphorylation	ANALPETTRFLINHR CCCCCHHHHHHHHHC	20.12	27017623
442	Acetylation	YAKKIAEKYGYGLSK HHHHHHHHHCCCCCC	34.65	24489116
525	N-linked_Glycosylation	TDTKYYWNLSKNIYR CCCCEEEECCCCHHH	20.51	-
528	Acetylation	KYYWNLSKNIYRFVG CEEEECCCCHHHHHH	51.00	24489116
544	Ubiquitination	IIDIDLLKTLHSVNE HHCHHHHHHHHHHCC	57.23	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	TUL1	P36096	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBPS_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBPS_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBPY_YEAST	PRC1	genetic	19897216
RSP5_YEAST	RSP5	physical	19744925
FLO1_YEAST	FLO1	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
RL19A_YEAST	RPL19B	genetic	27708008
RL19B_YEAST	RPL19B	genetic	27708008
COX7_YEAST	COX7	genetic	27708008
YME1_YEAST	YME1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.