FLO1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLO1_YEAST
• UniProt AC: P32768
• Protein Name: Flocculation protein FLO1
• Gene Name: FLO1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1537
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
• Protein Description: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion..
• Protein Sequence: MTMPHRYMFLAVFTLLALTSVASGATEACLPAGQRKSGMNINFYQYSLKDSSTYSNAAYMAYGYASKTKLGSVGGQTDISIDYNIPCVSSSGTFPCPQEDSYGNWGCKGMGACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFKFATVDDSAILSVGGATAFNCCAQQQPPITSTNFTIDGIKPWGGSLPPNIEGTVYMYAGYYYPMKVVYSNAVSWGTLPISVTLPDGTTVSDDFEGYVYSFDDDLSQSNCTVPDPSNYAVSTTTTTTEPWTGTFTSTSTEMTTVTGTNGVPTDETVIVIRTPTTASTIITTTEPWNSTFTSTSTELTTVTGTNGVRTDETIIVIRTPTTATTAITTTEPWNSTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEITTVTGTNGLPTDETIIVIRTPTTATTAMTTPQPWNDTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAITTTEPWNSTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAITTTQPWNDTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEITTVTGTTGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEMTTVTGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLVTTTTEPWTGTFTSTSTEMTTITGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTITGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTHVTGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLVTTTTEPWTGTFTSTSTEMSTVTGTNGLPTDETVIVVKTPTTAISSSLSSSSSGQITSSITSSRPIITPFYPSNGTSVISSSVISSSVTSSLFTSSPVISSSVISSSTTTSTSIFSESSKSSVIPTSSSTSGSSESETSSAGSVSSSSFISSESSKSPTYSSSSLPLVTSATTSQETASSLPPATTTKTSEQTTLVTVTSCESHVCTESISPAIVSTATVTVSGVTTEYTTWCPISTTETTKQTKGTTEQTTETTKQTTVVTISSCESDVCSKTASPAIVSTSTATINGVTTEYTTWCPISTTESRQQTTLVTVTSCESGVCSETASPAIVSTATATVNDVVTVYPTWRPQTANEESVSSKMNSATGETTTNTLAAETTTNTVAAETITNTGAAETKTVVTSSLSRSNHAETQTASATDVIGHSSSVVSVSETGNTKSLTSSGLSTMSQQPRSTPASSMVGYSTASLEISTYAGSANSLLAGSGLSVFIASLLLAII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTMPHRYMF ------CCCCHHHHH	51.19	23607784
7	Phosphorylation	-MTMPHRYMFLAVFT -CCCCHHHHHHHHHH	6.81	23607784
14	Phosphorylation	YMFLAVFTLLALTSV HHHHHHHHHHHHHHH	17.79	23607784
19	Phosphorylation	VFTLLALTSVASGAT HHHHHHHHHHHCCCC	18.62	23607784
20	Phosphorylation	FTLLALTSVASGATE HHHHHHHHHHCCCCC	19.28	23607784
23	Phosphorylation	LALTSVASGATEACL HHHHHHHCCCCCCCC	27.14	23607784
26	Phosphorylation	TSVASGATEACLPAG HHHHCCCCCCCCCCC	27.86	23607784
135	N-linked_Glycosylation	GFYTTPTNVTLEMTG EEEECCCCEEEEEEE	26.44	-
187	N-linked_Glycosylation	QPPITSTNFTIDGIK CCCCEEECEEEECCC	31.65	-
262	N-linked_Glycosylation	DDDLSQSNCTVPDPS CCCCCCCCCCCCCHH	20.17	-
329	N-linked_Glycosylation	ITTTEPWNSTFTSTS EEECCCCCCCCEECC	41.72	-
374	N-linked_Glycosylation	ITTTEPWNSTFTSTS EEECCCCCCCCEECC	41.72	-
419	N-linked_Glycosylation	MTTTQPWNDTFTSTS CCCCCCCCCCCCCCC	45.16	-
464	N-linked_Glycosylation	MTTTQPWNDTFTSTS CCCCCCCCCCCCCCC	45.16	-
509	N-linked_Glycosylation	MTTTQPWNDTFTSTS CCCCCCCCCCCCCCC	45.16	-
554	N-linked_Glycosylation	MTTPQPWNDTFTSTS CCCCCCCCCCCCCCC	45.16	-
599	N-linked_Glycosylation	ITTTEPWNSTFTSTS EEECCCCCCCCEECC	41.72	-
644	N-linked_Glycosylation	ITTTQPWNDTFTSTS EEECCCCCCCCCCCC	45.16	-
689	N-linked_Glycosylation	MTTTQPWNDTFTSTS CCCCCCCCCCCCCCC	45.16	-
734	N-linked_Glycosylation	MTTTQPWNDTFTSTS CCCCCCCCCCCCCCE	45.16	-
1114	N-linked_Glycosylation	ITPFYPSNGTSVISS EECCCCCCCCEEEEC	53.94	-
1514	GPI-anchor	LEISTYAGSANSLLA EEEEECCCCHHHHHC	19.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLO1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLO1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLO1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BPH1_YEAST	BPH1	genetic	23891562
GCS1_YEAST	GCS1	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
AIM34_YEAST	AIM34	genetic	27708008
FLO1_YEAST	FLO1	physical	25873380

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.