POLH_YEAST - dbPTM
POLH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID POLH_YEAST
UniProt AC Q04049
Protein Name DNA polymerase eta
Gene Name RAD30
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 632
Subcellular Localization Nucleus .
Protein Description DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts..
Protein Sequence MSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKEDPVVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKGEDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALKIFKSACDLVERASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGNYDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGIRDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCGKFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDAKVKQSDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKNLRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTKSYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLSMTITNFDIIDLQKTVVDMFGNQVHTFKSSAGKEDEEKTTSSKADEKTPKLECCKYQVTFTDQKALQEHADYHLALKLSEGLNGAEESSKNLSFGEKRLLFSRKRPNSQHTATPQKKQVTSSKNILSFFTRKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69PhosphorylationVSYAARKYGISRMDT
HHHHHHHHCCCCHHH		17.7127017623
72PhosphorylationAARKYGISRMDTIQE
HHHHHCCCCHHHHHH		19.7227017623
265PhosphorylationYTTSCGLSSTKNVCK
CCCCCCCHHHHCHHH		22.6527017623
266PhosphorylationTTSCGLSSTKNVCKL
CCCCCCHHHHCHHHH		48.7427017623
394PhosphorylationSSRPVVKSMMSNKNL
CCCHHHHHHHCCCCC		14.2230377154
414PhosphorylationNSIVDCISWLEVFCA
HHHHHHHHHHHHHHH		31.7527017623
424PhosphorylationEVFCAELTSRIQDLE
HHHHHHHHHHHHHHH		13.8927017623
425PhosphorylationVFCAELTSRIQDLEQ
HHHHHHHHHHHHHHH		39.7627017623
493PhosphorylationIKGKNKSYYPLTKLS
CCCCCCCCEECCEEE		15.6528889911
494PhosphorylationKGKNKSYYPLTKLSM
CCCCCCCEECCEEEE		10.0028889911
514PhosphorylationDIIDLQKTVVDMFGN
EEECCHHHHHHHHCC		16.8924961812
525PhosphorylationMFGNQVHTFKSSAGK
HHCCEEEEEHHCCCC		33.6224961812
589UbiquitinationNGAEESSKNLSFGEK
CCCHHHHHCCCHHHH		71.7923749301
596AcetylationKNLSFGEKRLLFSRK
HCCCHHHHHHHHHCC		49.0425381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseUFO1Q04511
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of POLH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of POLH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHSG_YEASTGPH1physical
11805837
PCNA_YEASTPOL30physical
11545742
REV1_YEASTREV1genetic
9409821
DPOZ_YEASTREV3genetic
9409821
REV7_YEASTREV7genetic
9409821
DPOD3_YEASTPOL32genetic
11027270
OGG1_YEASTOGG1genetic
10932195
REV1_YEASTREV1genetic
15284331
DPOZ_YEASTREV3genetic
15284331
DPOZ_YEASTREV3genetic
15520252
REV1_YEASTREV1genetic
15520252
SNF1_YEASTSNF1physical
16554755
SNU13_YEASTSNU13physical
16554755
GAL83_YEASTGAL83physical
16554755
AAKG_YEASTSNF4physical
16554755
LSM12_YEASTLSM12physical
16554755
ARO1_YEASTARO1genetic
17314980
REV1_YEASTREV1physical
17875922
DPOD3_YEASTPOL32genetic
17681555
MAG_YEASTMAG1genetic
18281311
DPOZ_YEASTREV3genetic
18281311
HLJ1_YEASTHLJ1physical
18467557
MRH4_YEASTMRH4physical
18467557
RAD5_YEASTRAD5genetic
18757916
MSH2_YEASTMSH2genetic
19635811
MSH6_YEASTMSH6genetic
19635811
PCNA_YEASTPOL30physical
19264809
DPOZ_YEASTREV3genetic
19635810
SEA4_YEASTSEA4genetic
20093466
FUI1_YEASTFUI1genetic
20093466
MTC4_YEASTMTC4genetic
20093466
RIM1_YEASTRIM1genetic
20093466
VCX1_YEASTVCX1genetic
20093466
DSE1_YEASTDSE1genetic
20093466
RTF1_YEASTRTF1genetic
20093466
MTO1_YEASTMTO1genetic
20093466
EDC1_YEASTEDC1genetic
20093466
GTS1_YEASTGTS1genetic
20093466
RRT6_YEASTRRT6genetic
20093466
CUL3_YEASTCUL3genetic
20093466
MGA1_YEASTMGA1genetic
20093466
DAL4_YEASTDAL4genetic
20093466
MDV1_YEASTMDV1genetic
20093466
SMA2_YEASTSMA2genetic
20093466
YMD8_YEASTYMD8genetic
20093466
INP1_YEASTINP1genetic
20093466
HFA1_YEASTHFA1genetic
20093466
DIA1_YEASTDIA1genetic
20093466
MSS18_YEASTMSS18genetic
20093466
PCNA_YEASTPOL30physical
18494853
PCNA1_ARATHPCNA1physical
18494853
PCNA2_ARATHPCNA2physical
18494853
UBC13_YEASTUBC13genetic
10880451
MMS2_YEASTMMS2genetic
10880451
UBC13_YEASTUBC13genetic
20453836
SRS2_YEASTSRS2genetic
11809886
MMS2_YEASTMMS2genetic
20403322
EXO1_YEASTEXO1genetic
20932474
PCNA_YEASTPOL30physical
20837403
UBI4P_YEASTUBI4physical
20837403
UBI4P_YEASTUBI4physical
21483899
PCNA_YEASTPOL30physical
22308326
REV1_YEASTREV1genetic
23550131
DEF1_YEASTDEF1genetic
24465179
MMS2_YEASTMMS2genetic
24465179
RAD5_YEASTRAD5genetic
25806814
FUN30_YEASTFUN30genetic
25806814
DPOZ_YEASTREV3genetic
23858457
DPOZ_YEASTREV3genetic
24210827
RT107_YEASTRTT107genetic
26439300
FUI1_YEASTFUI1genetic
27708008
EDE1_YEASTEDE1genetic
27708008
SEA4_YEASTSEA4genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
UME6_YEASTUME6genetic
27708008
RRT6_YEASTRRT6genetic
27708008
MTO1_YEASTMTO1genetic
27708008
ASK10_YEASTASK10genetic
27708008
MGA1_YEASTMGA1genetic
27708008
OTU2_YEASTOTU2genetic
27708008
AP3S_YEASTAPS3genetic
27708008
MDV1_YEASTMDV1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
ACE2_YEASTACE2genetic
27708008
ERFB_YEASTERF2genetic
27708008
CDC73_YEASTCDC73genetic
27708008
RCO1_YEASTRCO1genetic
27708008
SAS2_YEASTSAS2genetic
27708008
INP1_YEASTINP1genetic
27708008
DIA1_YEASTDIA1genetic
27708008
TEP1_YEASTTEP1genetic
27708008
PT494_YEASTPET494genetic
27708008
MSS18_YEASTMSS18genetic
27708008
PCNA_YEASTPOL30physical
27707542
REV1_YEASTREV1physical
26903512
PCNA_YEASTPOL30physical
26903512
PCNA_YEASTPOL30physical
28383730
PCNA_YEASTPOL30physical
27325737
REV1_YEASTREV1physical
27325737
RNH2A_YEASTRNH201genetic
26340535
RAD5_YEASTRAD5genetic
25310987
DPOD_YEASTPOL3genetic
29281621
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of POLH_YEAST

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Related Literatures of Post-Translational Modification

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