OGG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OGG1_YEAST
• UniProt AC: P53397
• Protein Name: N-glycosylase/DNA lyase
• Gene Name: OGG1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 376
• Subcellular Localization: Nucleus.
• Protein Description: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion..
• Protein Sequence: MSYKFGKLAINKSELCLANVLQAGQSFRWIWDEKLNQYSTTMKIGQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIPSDKAFAKLSPQGIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTIDGVAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISANKNHLKELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEIGGTSGSTTTGTIKKRKWDMIKETEAIVTKQMKLKVELSDLHIKEAKID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
196	Phosphorylation	RAKYIIETARKLVND HHHHHHHHHHHHHCC	22.73	27017623
287	Phosphorylation	LKELRTKYNALPISR HHHHHHHHHCCCCCH	12.68	22890988
293	Phosphorylation	KYNALPISRKKINLE HHHCCCCCHHHCCCC	35.79	22890988
334	Phosphorylation	EIGGTSGSTTTGTIK EECCCCCCCCCCEEE	23.50	27214570
339	Phosphorylation	SGSTTTGTIKKRKWD CCCCCCCEEEECCCC	27.77	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OGG1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OGG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OGG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD14_YEAST	RAD14	genetic	10077187
UBC2_YEAST	RAD6	genetic	15388802
RAD18_YEAST	RAD18	genetic	15388802
MSH6_YEAST	MSH6	genetic	15388802
POLH_YEAST	RAD30	genetic	15388802
NTH2_YEAST	NTG2	genetic	15449310
IMB1_YEAST	KAP95	physical	16554755
IMA1_YEAST	SRP1	physical	16554755
SSL1_YEAST	SSL1	genetic	17314980
TAF12_YEAST	TAF12	genetic	17314980
RIM1_YEAST	RIM1	genetic	17314980
CST9_YEAST	CST9	genetic	17314980
UME6_YEAST	UME6	genetic	17314980
DPOD3_YEAST	POL32	genetic	17314980
PCNA_YEAST	POL30	genetic	17314980
NTH1_YEAST	NTG1	genetic	11239005
POLH_YEAST	RAD30	genetic	17715002
POLH_YEAST	RAD30	genetic	19635811
MSH2_YEAST	MSH2	genetic	19635811
MSH6_YEAST	MSH6	genetic	19635811
RAD18_YEAST	RAD18	genetic	19264809
POLH_YEAST	RAD30	genetic	19264809
PCNA_YEAST	POL30	genetic	19264809
DPOD3_YEAST	POL32	genetic	19264809
PIF1_YEAST	PIF1	genetic	19942858
TERT_YEAST	EST2	genetic	19942858
RAD52_YEAST	RAD52	genetic	19942858
MSH1_YEAST	MSH1	genetic	19056520
APTX_YEAST	HNT3	genetic	20399152
ATU2_YEAST	CCC2	genetic	26275420
HPH2_YEAST	FRT2	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
MGMT_YEAST	MGT1	genetic	27708008
GNTK_YEAST	YDR248C	genetic	27708008
POLH_YEAST	RAD30	genetic	27708008
PUF6_YEAST	PUF6	genetic	27708008
APA2_YEAST	APA2	genetic	27708008
MMS2_YEAST	MMS2	genetic	27708008
RS25A_YEAST	RPS25A	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
KEL1_YEAST	KEL1	genetic	27708008
MGA2_YEAST	MGA2	genetic	27708008
CBPS_YEAST	CPS1	genetic	27708008
SWE1_YEAST	SWE1	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
YRA2_YEAST	YRA2	genetic	27708008
MEH1_YEAST	MEH1	genetic	27708008
SRL3_YEAST	SRL3	genetic	27708008
MHT1_YEAST	MHT1	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
RNH2A_YEAST	RNH201	genetic	27708008
EOS1_YEAST	EOS1	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
RTC1_YEAST	RTC1	genetic	27708008
VAM3_YEAST	VAM3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.