MSH1_YEAST - dbPTM
MSH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSH1_YEAST
UniProt AC P25846
Protein Name DNA mismatch repair protein MSH1, mitochondrial
Gene Name MSH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 959
Subcellular Localization Mitochondrion .
Protein Description Important for mitochondrial DNA (mtDNA) stability and repair. Recognizes and binds to base-base and small insertion-deletion mismatches in mtDNA. ATP binding and hydrolysis is crucial for function. Binding to a mismatched base pair attenuates ATP hydrolysis. Also involved in proper sorting of mtDNA during mtDNA transmission..
Protein Sequence MKHFFRLPTAFRPISRVSLRYSSTDTAQPKISKLKISFNKISESNSEKKDNLGSIDTRNCLSTQQDDKLSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYFEQAIRYAPELNISLTNRAYSHGKVPFAGFPVHQLSRHLKMLVNNCGYSVTIAEQFKKKDVADNEANKFYRRVTRIVTPGTFIDEAFENLRENTYLLNIEFPENCMSQVADTSLKVGICWCDVSTGEIFVQQVYLRDLVSAITRIQPKEILLDERLLEFHIESGTWYPELVELKKFFIKYQKMPSQHRTIESFYGLFNLGGKEATERQLKIQFQTFTQKELAALRNTLIYVSNHLPDFSINFQIPQRQLATAIMQIDSRTSTALELHSTVRDNNKKGSLLSSIRRTVTPSGTRLLSQWLSGPSLDLKEIKKRQKIVAFFKDNRDITETLRTMLKKVNDLSRILQKFSFGRGEALELIQMARSLEVSREIRKYLLNNTSLMKATLKSQITQLTESLNFEKNLIDDILKFLNEEELAKSQDAKQNADVTRMLDIDVKDKKESNKDEIFELRDFIVNPSFNTKLRKLHDTYQGVWQKKTEYNALLKGFFVGDLGAKTFTLKERQNGEYALHVTGTASSLKKIDELISKSTEYHGSCFHILQKSSQTRWLSHKIWTDLGHELELLNLKIRNEEANIIDLFKRKFIDRSNEVRQVATTLGYLDTLSSFAVLANERNLVCPKVDESNKLEVVNGRHLMVEEGLSARSLETFTANNCELAKDNLWVITGPNMGGKSTFLRQNAIIVILAQIGCFVPCSKARVGIVDKLFSRVGSADDLYNEMSTFMVEMIETSFILQGATERSLAILDEIGRGTSGKEGISIAYATLKYLLENNQCRTLFATHFGQELKQIIDNKCSKGMSEKVKFYQSGITDLGGNNFCYNHKLKPGICTKSDAIRVAELAGFPMEALKEAREILG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationDTAQPKISKLKISFN
CCCCCCCEEEEEEHH		37.7519795423
37PhosphorylationKISKLKISFNKISES
CCEEEEEEHHHCCCC		22.6019795423
71PhosphorylationQQDDKLSSTEPSKAS
CCCCCCCCCCCCCCC		47.4230377154
486PhosphorylationRKYLLNNTSLMKATL
HHHHHCCHHHHHHHH		23.3619779198
492PhosphorylationNTSLMKATLKSQITQ
CHHHHHHHHHHHHHH		29.2419779198
857PhosphorylationDEIGRGTSGKEGISI
HHHCCCCCCCCHHHH		51.1728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPPB_YEASTMAS1physical
11805837
MPPA_YEASTMAS2physical
11805837
CCE1_YEASTCCE1genetic
16337661
DIN7_YEASTDIN7genetic
16337661
MHR1_YEASTMHR1genetic
16337661
CIN8_YEASTCIN8genetic
17314980
HAT2_YEASTHAT2genetic
17314980
MUM2_YEASTMUM2genetic
17314980
APN1_YEASTAPN1genetic
19398768
NTH1_YEASTNTG1genetic
19398768
OGG1_YEASTOGG1genetic
19398768
SNF5_YEASTSNF5genetic
20093466
YG35_YEASTYGR125Wgenetic
20093466
AMA1_YEASTAMA1genetic
20093466
MAL12_YEASTMAL12genetic
20093466
MMM1_YEASTMMM1genetic
20093466
MKS1_YEASTMKS1genetic
20093466
DPOG_YEASTMIP1genetic
22114710
HSP7F_YEASTSSE1physical
22940862
KPYK1_YEASTCDC19physical
22940862
EF1A_YEASTTEF2physical
22940862
SSB1_YEASTSSB1physical
22940862
DED1_YEASTDED1physical
22940862
MSH1_YEASTMSH1physical
22940862
HSP72_YEASTSSA2physical
22940862
PABP_YEASTPAB1physical
22940862
HSP71_YEASTSSA1physical
22940862
NTR2_YEASTNTR2physical
22875988
NCA2_YEASTNCA2physical
22875988
ETR1_YEASTETR1genetic
27708008
REI1_YEASTREI1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
IPT1_YEASTIPT1genetic
27708008
PP2C2_YEASTPTC2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
MSN4_YEASTMSN4genetic
27708008
MDL2_YEASTMDL2genetic
27708008
SYT1_YEASTSYT1genetic
27708008
CND2_YEASTBRN1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
SC61G_YEASTSSS1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
RLI1_YEASTRLI1genetic
27708008
SECU_YEASTPDS1genetic
27708008
APC4_YEASTAPC4genetic
27708008
DOP1_YEASTDOP1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
SEC1_YEASTSEC1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
CND3_YEASTYCG1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PTI1_YEASTPTI1genetic
27708008
PRS7_YEASTRPT1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
FCP1_YEASTFCP1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
SWC3_YEASTSWC3genetic
27708008
LTE1_YEASTLTE1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
GEM1_YEASTGEM1genetic
27708008
PEX22_YEASTPEX22genetic
27708008
MGR1_YEASTMGR1genetic
27708008
PET18_YEASTPET18genetic
27708008
PEX19_YEASTPEX19genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
UFD2_YEASTUFD2genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
GCS1_YEASTGCS1genetic
27708008
BCS1_YEASTBCS1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
GET2_YEASTGET2genetic
27708008
KA122_YEASTKAP122genetic
27708008
CGR1_YEASTCGR1genetic
27708008
LCL3_YEASTLCL3genetic
27708008
MAN1_YEASTAMS1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
AMA1_YEASTAMA1genetic
27708008
MAL12_YEASTMAL12genetic
27708008
VPS53_YEASTVPS53genetic
27708008
IME1_YEASTIME1genetic
27708008
MIC60_YEASTMIC60genetic
27708008
SRL3_YEASTSRL3genetic
27708008
DNM1_YEASTDNM1genetic
27708008
MMM1_YEASTMMM1genetic
27708008
CTK3_YEASTCTK3genetic
27708008
SKY1_YEASTSKY1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
DUN1_YEASTDUN1genetic
28678842
VPS53_YEASTVPS53genetic
27453043
EAR1_YEASTEAR1genetic
27453043
HDA1_YEASTHDA1genetic
27453043
CKS1_YEASTCKS1genetic
27453043
SERB_YEASTSER2genetic
27453043
CYPC_YEASTCPR3genetic
27453043
AIM33_YEASTAIM33genetic
27453043
CDC42_YEASTCDC42genetic
27453043
PTPA1_YEASTRRD1genetic
27453043
DPOE_YEASTPOL2genetic
27453043
MTM1_YEASTMTM1genetic
27453043
NM111_YEASTNMA111genetic
27453043
PP4C_YEASTPPH3genetic
27453043
RPAC1_YEASTRPC40genetic
27453043
MRC1_YEASTMRC1genetic
27453043
CDK1_YEASTCDC28genetic
27453043
VPS15_YEASTVPS15genetic
27453043
FCP1_YEASTFCP1genetic
27453043
SYFM_YEASTMSF1genetic
27453043
CEM1_YEASTCEM1genetic
27453043
TSC10_YEASTTSC10genetic
27453043
SWI4_YEASTSWI4genetic
27453043
SYLM_YEASTNAM2genetic
27453043
HFA1_YEASTHFA1genetic
27453043
IRA2_YEASTIRA2genetic
27453043
RS19B_YEASTRPS19Bgenetic
27453043
IRC21_YEASTIRC21genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857, AND MASSSPECTROMETRY.

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