MAN1_YEAST - dbPTM
MAN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAN1_YEAST
UniProt AC P22855
Protein Name Alpha-mannosidase
Gene Name AMS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1083
Subcellular Localization Vacuole . Localizes to the inner surface of the vacuolar membrane. Under nutrient-rich conditions, the protein is delivered to the vacuole by the cytoplasm to vacuole targeting (Cvt) pathway. Under starvation conditions, the protein is localized thro
Protein Description Degrades free oligosaccharides in the vacuole..
Protein Sequence MSSEDIIYDPQFKPVQGIYENRLRQFIDTGGDYHDLNLPKFYDKKRISLDHDHVKVWWYQVSFERGSSPVSPDKRPSWKSIIERDKKGELEFREANINQPFGPSWSTTWFKVKISLPEDWVKSNEQLLFQWDCSNEGIVIDPKTLIPVTAFSGGERTEYVLPKTSDGKHFFYIEAGNNGMFGCGAGSTINPPDDNRFFHLRKADIVWPDLDARALYIDFWMLGDAARELPGDSWQKHQARQLGNAVMNLFDPNDRSSVRKCRELLQREYFDSFLESSKVYEQGESQVLTNVYGIGNCHIDTAWLWPFAETRRKIVRSWSSQCTLMDRFPEYKFVASQAQQFKWLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFGLKSKIFWLPDTFGYSSQMPQLCRLSGIDKFLTQKLSWNNINSFPHSTFNWAGIDGSQLLTHMPPGNTYTADSHFGDVLRTAKQNKTPEYYGSGLMLYGKGDGGGGPTEEMLQKMRRIRSMNNRNGNVIPKLQVGITVDEFYDDILKRTNQGHDLPTWSGELYFEFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINELWENVLLCQFHDVLPGSCIEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQSKADLVEMRTLTWSKPEKVSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKTGVITSITDETLGVEYLDTEHGRNKLGANQFVIYDDKPLGWQAWDTELYSVNQYKYVTKPKKVQVSCNTKEKCAVEVIFQISEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDFASYETQFGITKRPTHYNTSWDVAKFEVCHHKFADYSEYSKGVSILNDCKYGFSTHGNLMRLSLLRSPKAPDAHADMGTHEIKYAIYPHRGALSSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISISGDENVILSNIKRGEDDSAVKSNYSLNPRDEQSIVVRVYESLGGESFASLNTTLNLKRIEKVDNLEMKVYKSLTATRDESNHAINRIPIKLRPFEIASFRLYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSEDIIYD
------CCHHHCCCC		54.4622814378
2Phosphorylation------MSSEDIIYD
------CCHHHCCCC		54.4622369663
3Phosphorylation-----MSSEDIIYDP
-----CCHHHCCCCC		51.6622369663
67PhosphorylationQVSFERGSSPVSPDK
EEEECCCCCCCCCCC		37.3829136822
68PhosphorylationVSFERGSSPVSPDKR
EEECCCCCCCCCCCC		31.9529136822
71PhosphorylationERGSSPVSPDKRPSW
CCCCCCCCCCCCCCH		30.6629136822
272PhosphorylationLQREYFDSFLESSKV
HHHHHHHHHHHHCCH		23.1027214570
487PhosphorylationRTAKQNKTPEYYGSG
HHHHCCCCCCCCCCC		28.9719779198
490PhosphorylationKQNKTPEYYGSGLML
HCCCCCCCCCCCEEE		17.8427017623
491PhosphorylationQNKTPEYYGSGLMLY
CCCCCCCCCCCEEEE		11.8027017623
493PhosphorylationKTPEYYGSGLMLYGK
CCCCCCCCCEEEECC		16.7828889911
498PhosphorylationYGSGLMLYGKGDGGG
CCCCEEEECCCCCCC		11.6528889911
508PhosphorylationGDGGGGPTEEMLQKM
CCCCCCCHHHHHHHH		48.1027017623
917PhosphorylationHGNLMRLSLLRSPKA
CCCCHHHHHHCCCCC		18.2628889911
949PhosphorylationPHRGALSSDTVKLAH
CCCCCCCCCHHHHHH		37.8427017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG19_YEASTATG19physical
11283351
AMPL_YEASTAPE1physical
18719252
ATG34_YEASTATG34physical
18719252
ATG34_YEASTATG34physical
20639194
ATG19_YEASTATG19physical
21343297
MED14_YEASTRGR1genetic
27708008
KRR1_YEASTKRR1genetic
27708008
FAL1_YEASTFAL1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SRPR_YEASTSRP101genetic
27708008
RSP5_YEASTRSP5genetic
27708008
STS1_YEASTSTS1genetic
27708008
ORC1_YEASTORC1genetic
27708008
MED11_YEASTMED11genetic
27708008
NOP2_YEASTNOP2genetic
27708008
SEC63_YEASTSEC63genetic
27708008
MAN1_YEASTAMS1physical
27266708
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAN1_YEAST

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Related Literatures of Post-Translational Modification

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