dbPTM

ATG34_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATG34_YEAST
UniProt AC	Q12292
Protein Name	Autophagy-related protein 34
Gene Name	ATG34
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	412
Subcellular Localization	Preautophagosomal structure membrane Peripheral membrane protein . Membrane-associated protein found in pre-autophagosomal structure and other perivacuolar punctate structures.
Protein Description	Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole..
Protein Sequence	MKIAVETTLFDFFVIDQFKKSTFSAPNTKVDTIKGCINKFIEQFNVYDEQHIFWQPPGKSNVRLLSNANDFGQLGNFLHKKIKCNIFIGEEALRKYDLNICGPYDKFVENSDPSVKKVVNRDDVMLSRKCLNIISEQLSILEKSISKAQNQVLQSSEVEGKKCIILPEDKPELIKFFSKFETSVQLQEVYEGYKVYEKLLQKFGGQKKRMESFLNENTPMSGAEAIKQINISEELKEKGERLTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGNCTFEFSSQISEVFSIKMGPHEIGIKGQKELWFFPSLPTPLSNYTMKVVNQDGETILVGKCADSNEITLKSPLASFSTGSFQTGSFHTLQDPTNVFRADALSSPDESSIMSTPFLGETDEVYNSGSTLSRPFTWEEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
244	Phosphorylation	EKGERLTTPNDPLLH HCCCCCCCCCCCCEE	25.37	28889911
353	Phosphorylation	SPLASFSTGSFQTGS CCCEEECCCCCCCCC	34.53	19779198
355	Phosphorylation	LASFSTGSFQTGSFH CEEECCCCCCCCCCC	17.80	19779198
358	Phosphorylation	FSTGSFQTGSFHTLQ ECCCCCCCCCCCCCC	32.55	19779198
360	Phosphorylation	TGSFQTGSFHTLQDP CCCCCCCCCCCCCCC	19.76	25752575
363	Phosphorylation	FQTGSFHTLQDPTNV CCCCCCCCCCCCCCC	24.89	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATG34_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATG34_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATG34_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG34_YEAST	ATG34	physical	20639194
MAN1_YEAST	AMS1	physical	25281559
ATG8_YEAST	ATG8	physical	24705553
GIS1_YEAST	GIS1	genetic	27708008
DFM1_YEAST	DFM1	genetic	27708008
RCY1_YEAST	RCY1	genetic	27708008
ACE2_YEAST	ACE2	genetic	27708008
ARGR1_YEAST	ARG80	genetic	27708008
CND2_YEAST	BRN1	genetic	27708008
SNU56_YEAST	SNU56	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
MED6_YEAST	MED6	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
SEC65_YEAST	SEC65	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
SYA_YEAST	ALA1	genetic	27708008
YAJ9_YEAST	YAR029W	genetic	27708008
RTG3_YEAST	RTG3	genetic	27708008
PP2A2_YEAST	PPH22	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
RAD4_YEAST	RAD4	genetic	27708008
RIR3_YEAST	RNR3	genetic	27708008
BZRD_YEAST	IRC24	genetic	27708008
BNA3_YEAST	BNA3	genetic	27708008
DOA1_YEAST	DOA1	genetic	27708008
PSR1_YEAST	PSR1	genetic	27708008
YL422_YEAST	YLR422W	genetic	27708008
PALI_YEAST	RIM9	genetic	27708008
MSS11_YEAST	MSS11	genetic	27708008
KES1_YEAST	KES1	genetic	27708008
ATG5_YEAST	ATG5	physical	27879200

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATG34_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-244; SER-360 ANDTHR-363, AND MASS SPECTROMETRY.	18407956 [Abstract]