GIS1_YEAST - dbPTM
GIS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIS1_YEAST
UniProt AC Q03833
Protein Name Transcriptional activator/repressor GIS1
Gene Name GIS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 894
Subcellular Localization Nucleus .
Protein Description Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1..
Protein Sequence MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFNDKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65PhosphorylationPPAESLKTIQLDSPI
CCHHHCCEEECCCHH		21.1721126336
70PhosphorylationLKTIQLDSPIQQQAK
CCEEECCCHHHHHHH		32.2822369663
109PhosphorylationQWKNLAESLDSRISQ
HHHHHHHHHHHHHHC		31.6930377154
115PhosphorylationESLDSRISQGDFNDK
HHHHHHHHCCCCCHH		27.3122369663
125AcetylationDFNDKTLKENCRVDS
CCCHHHHHHHCCCCC		52.7125381059
340PhosphorylationSGPFSNLSYDSNESE
CCCCCCCCCCCCCCH		31.0121440633
341PhosphorylationGPFSNLSYDSNESEQ
CCCCCCCCCCCCCHH		26.9320377248
343PhosphorylationFSNLSYDSNESEQRG
CCCCCCCCCCCHHCC		33.9717563356
346PhosphorylationLSYDSNESEQRGSIT
CCCCCCCCHHCCCCC		43.1920377248
351PhosphorylationNESEQRGSITDNDND
CCCHHCCCCCCCCCH		25.2220377248
353PhosphorylationSEQRGSITDNDNDLF
CHHCCCCCCCCCHHH		30.3722369663
365PhosphorylationDLFQKVRSFDELLNH
HHHHHHHCHHHHHHC		39.7822369663
373PhosphorylationFDELLNHSSQELQNL
HHHHHHCCHHHHHCC		32.4222369663
374PhosphorylationDELLNHSSQELQNLE
HHHHHCCHHHHHCCC		21.8122369663
398PhosphorylationINMNRPQSSSLRSTT
CCCCCCCCCCCCCCC		25.2822369663
399PhosphorylationNMNRPQSSSLRSTTP
CCCCCCCCCCCCCCC		28.3022369663
400PhosphorylationMNRPQSSSLRSTTPN
CCCCCCCCCCCCCCC		32.8022369663
403PhosphorylationPQSSSLRSTTPNGVN
CCCCCCCCCCCCHHH		41.7622369663
404PhosphorylationQSSSLRSTTPNGVNQ
CCCCCCCCCCCHHHH		39.5822369663
405PhosphorylationSSSLRSTTPNGVNQF
CCCCCCCCCCHHHHH		18.9222369663
418PhosphorylationQFLNMNQTTISRISS
HHHCCCHHHHHHHCH		22.5422369663
419PhosphorylationFLNMNQTTISRISSP
HHCCCHHHHHHHCHH		13.7522369663
421PhosphorylationNMNQTTISRISSPLL
CCCHHHHHHHCHHHH		22.8222369663
424PhosphorylationQTTISRISSPLLSRM
HHHHHHHCHHHHHHH		25.4522890988
425PhosphorylationTTISRISSPLLSRMM
HHHHHHCHHHHHHHH		19.7322369663
429PhosphorylationRISSPLLSRMMDLSN
HHCHHHHHHHHCHHH		26.3022890988
448AcetylationTLDDPGSKFKRKVLT
CCCCCCCHHCHHCCC		61.9024489116
580PhosphorylationLANSATASPRLTLPP
HHHCCCCCCCCCCCC		13.2428889911
670PhosphorylationNSGLAPLSPSTSNIP
CCCCCCCCCCCCCCC		18.7522369663
672PhosphorylationGLAPLSPSTSNIPFL
CCCCCCCCCCCCCCH		40.8822369663
673PhosphorylationLAPLSPSTSNIPFLK
CCCCCCCCCCCCCHH		29.2222369663
674PhosphorylationAPLSPSTSNIPFLKR
CCCCCCCCCCCCHHC		36.7821440633
680AcetylationTSNIPFLKRNNVVTL
CCCCCCHHCCCEEEE		54.1624489116
686PhosphorylationLKRNNVVTLNISREA
HHCCCEEEEEECHHH		15.1422369663
690PhosphorylationNVVTLNISREASKSP
CEEEEEECHHHHCCC		24.0122369663
694PhosphorylationLNISREASKSPISSF
EEECHHHHCCCHHHH		28.9822369663
695AcetylationNISREASKSPISSFV
EECHHHHCCCHHHHH		68.2624489116
696PhosphorylationISREASKSPISSFVN
ECHHHHCCCHHHHHH		25.6022369663
699PhosphorylationEASKSPISSFVNDYR
HHHCCCHHHHHHHCC		22.5522369663
700PhosphorylationASKSPISSFVNDYRS
HHCCCHHHHHHHCCC		33.6522369663
705PhosphorylationISSFVNDYRSPLGVS
HHHHHHHCCCCCCCC		14.0522369663
712PhosphorylationYRSPLGVSNPLMYSS
CCCCCCCCCCCCEEC		30.8227017623
724PhosphorylationYSSTINDYSNGTGIR
EECCCCCCCCCCCCC		10.2727017623
725PhosphorylationSSTINDYSNGTGIRQ
ECCCCCCCCCCCCCC		31.4827017623
734PhosphorylationGTGIRQNSNNINPLD
CCCCCCCCCCCCCCC		23.9422369663
745PhosphorylationNPLDAGPSFSPLHKK
CCCCCCCCCCCCCCC		37.1222369663
747PhosphorylationLDAGPSFSPLHKKPK
CCCCCCCCCCCCCCC		30.7822369663
772PhosphorylationDSNNFDYSFTGNKQE
CCCCCCCCCCCCCCC		20.4121551504
797PhosphorylationNNNDNYRTSSMNNNG
CCCCCCCCCCCCCCC		18.1322369663
798PhosphorylationNNDNYRTSSMNNNGN
CCCCCCCCCCCCCCC		20.7022369663
799PhosphorylationNDNYRTSSMNNNGNN
CCCCCCCCCCCCCCC		25.5622369663
813AcetylationNYQAHSSKFGENEVI
CCCCCCCCCCCCCEE		61.4724489116
822PhosphorylationGENEVIMSDHGKIYI
CCCCEEECCCCEEEE		18.4822369663
838PhosphorylationRECNRQFSSGHHLTR
CCCCCCCCCCCCCCC		27.3728889911
839PhosphorylationECNRQFSSGHHLTRH
CCCCCCCCCCCCCCC		43.3527017623
844PhosphorylationFSSGHHLTRHKKSVH
CCCCCCCCCCCCCCC		26.7728889911
858PhosphorylationHSGEKPHSCPRCGKR
CCCCCCCCCCCCCHH		34.0528889911
878AcetylationHVLQHLNKKIPCTQE
HHHHHHHHCCCCCHH		59.4425381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GIS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SGS1_YEASTSGS1physical
17043893
SIR4_YEASTSIR4physical
17043893
MFT1_YEASTMFT1physical
17043893
GDS1_YEASTGDS1physical
17043893
SIZ2_YEASTNFI1physical
17043893
MGA2_YEASTMGA2physical
17043893
JIP5_YEASTJIP5physical
17043893
FIR1_YEASTFIR1physical
17043893
NIS1_YEASTNIS1physical
17043893
BUD27_YEASTBUD27physical
17043893
ZRG8_YEASTZRG8physical
17043893
PIG2_YEASTPIG2physical
17043893
TAF8_YEASTTAF8physical
17043893
ESC1_YEASTESC1physical
17043893
BMS1_YEASTBMS1physical
17043893
CSM3_YEASTCSM3physical
17043893
JIP4_YEASTJIP4physical
17043893
PAN1_YEASTPAN1physical
17043893
WRN_HUMANWRNphysical
17043893
MSN2_YEASTMSN2genetic
18225956
MSN4_YEASTMSN4genetic
18225956
SSB1_YEASTSSB1physical
19536198
SCH9_YEASTSCH9genetic
19687253
SODC_YEASTSOD1genetic
19687253
SODM_YEASTSOD2genetic
19687253
STB5_YEASTSTB5genetic
20959818
H4_YEASTHHF1genetic
20959818
RPA14_YEASTRPA14genetic
20959818
GLN3_YEASTGLN3genetic
20959818
SAC3_YEASTSAC3genetic
20959818
RPH1_YEASTRPH1genetic
10628841
PP2C1_YEASTPTC1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
VMS1_YEASTVMS1genetic
21127252
DUN1_YEASTDUN1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
GIS1_YEASTGIS1physical
21680636
RPH1_YEASTRPH1genetic
22363679
JHD1_YEASTJHD1genetic
25774516
MSN2_YEASTMSN2genetic
23697803
MSN4_YEASTMSN4genetic
23697803
MDM10_YEASTMDM10genetic
27708008
HAP3_YEASTHAP3genetic
27708008
EDE1_YEASTEDE1genetic
27708008
YBQ3_YEASTYBR053Cgenetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
PCH2_YEASTPCH2genetic
27708008
SNF5_YEASTSNF5genetic
27708008
ATG22_YEASTATG22genetic
27708008
RV161_YEASTRVS161genetic
27708008
BUD31_YEASTBUD31genetic
27708008
IMG2_YEASTIMG2genetic
27708008
YCZ0_YEASTYCR100Cgenetic
27708008
GGA1_YEASTGGA1genetic
27708008
RV167_YEASTRVS167genetic
27708008
SAC7_YEASTSAC7genetic
27708008
MTHR2_YEASTMET13genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
MTO1_YEASTMTO1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
HXT5_YEASTHXT5genetic
27708008
ICE2_YEASTICE2genetic
27708008
NUC1_YEASTNUC1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
PSR1_YEASTPSR1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
ALG6_YEASTALG6genetic
27708008
LGE1_YEASTLGE1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
TKT1_YEASTTKL1genetic
27708008
RPH1_YEASTRPH1genetic
25660547
RPH1_YEASTRPH1genetic
24999627
MSN2_YEASTMSN2genetic
26103122
MSN4_YEASTMSN4genetic
26103122
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-405; SER-425;SER-580; SER-670; SER-696 AND SER-747, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; SER-694 ANDSER-696, AND MASS SPECTROMETRY.

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