MTHR2_YEAST - dbPTM
MTHR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTHR2_YEAST
UniProt AC P53128
Protein Name Methylenetetrahydrofolate reductase 2
Gene Name MET13
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 600
Subcellular Localization
Protein Description
Protein Sequence MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEFPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTPTSINDVAFLVINYLNGNLKCLPWSDIPINDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQYLEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQPTIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPDDQIHSILLSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKITEKLEQ
------CCHHHHHHH		59.3317644757
6Ubiquitination--MKITEKLEQHRQT
--CCHHHHHHHHHHH		48.9917644757
6Acetylation--MKITEKLEQHRQT
--CCHHHHHHHHHHH		48.9922865919
16UbiquitinationQHRQTSGKPTYSFEY
HHHHHCCCCEEEEEE		33.6717644757
27UbiquitinationSFEYFVPKTTQGVQN
EEEEECCCCCHHHHH		59.9217644757
125PhosphorylationPRDAENWTPVEGGFQ
CCCCCCCCCCCCHHH		29.1023749301
142UbiquitinationKDLIKYIKSKYGDHF
HHHHHHHHHHHCCCE		37.4917644757
144UbiquitinationLIKYIKSKYGDHFAI
HHHHHHHHHCCCEEE		48.5317644757
166UbiquitinationCHPELPNKDVKLDLE
CCCCCCCCCCCCCHH		63.0617644757
169UbiquitinationELPNKDVKLDLEYLK
CCCCCCCCCCHHHHH		46.5517644757
176UbiquitinationKLDLEYLKQKIDAGG
CCCHHHHHHHHHCCC		48.9517644757
176AcetylationKLDLEYLKQKIDAGG
CCCHHHHHHHHHCCC		48.9524489116
249UbiquitinationSSRLDPIKDDDELVR
HHCCCCCCCCHHHHH		61.5717644757
249AcetylationSSRLDPIKDDDELVR
HHCCCCCCCCHHHHH		61.5724489116
269UbiquitinationLIVEMCQKLLDSGYV
HHHHHHHHHHHCCCC		46.2017644757
288UbiquitinationIYTMNLEKAPLMILE
EEECCCCCCCEEHHH		59.4717644757
318UbiquitinationLAVLPWRKSLNPKRK
CCCCCCHHCCCCCCC		56.2617644757
325UbiquitinationKSLNPKRKNEEVRPI
HCCCCCCCCCCCCCC		74.8817644757
335UbiquitinationEVRPIFWKRRPYSYV
CCCCCCCCCCCCCEE		27.9917644757
335AcetylationEVRPIFWKRRPYSYV
CCCCCCCCCCCCCEE		27.9924489116
363PhosphorylationGRFGDSSSPAFGDLD
CCCCCCCCCCCCCCC		24.9727214570
383UbiquitinationLIRQSANKCLELWST
HHHHHHHHHHHHHCC		39.6617644757
410UbiquitinationNYLNGNLKCLPWSDI
HHHCCCEEEEEHHHC		37.4117644757
427UbiquitinationNDEINPIKAHLIELN
CCCCCHHHHHHEEEC		30.8917644757
455UbiquitinationNGIRSNDKIHGWGPK
CCCCCCCCCCCCCCC		40.6317644757
462UbiquitinationKIHGWGPKDGYVYQK
CCCCCCCCCCCEEEH		60.9017644757
483AcetylationLPKTKLPKLIDTLKN
CCCCCCCHHHHHHHC		69.3924489116
487PhosphorylationKLPKLIDTLKNNEFL
CCCHHHHHHHCCCEE		32.4122369663
489UbiquitinationPKLIDTLKNNEFLTY
CHHHHHHHCCCEEEE		60.8717644757
514UbiquitinationSNHPDNSKSNAVTWG
HCCCCCCCCCCCCEE		54.7217644757
536UbiquitinationLQPTIVEKISFLAWK
CCCCHHHHHHHHHHH		32.5317644757
543UbiquitinationKISFLAWKEEFYHIL
HHHHHHHHHHHHHHH		41.5817644757
554UbiquitinationYHILNEWKLNMNKYD
HHHHHHHCCCCCCCC		24.6517644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTHR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTHR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTHR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTHR1_YEASTMET12physical
16554755
MTHR1_YEASTMET12physical
16429126
GGPPS_YEASTBTS1genetic
21623372
SYSM_YEASTDIA4genetic
21623372
COQ7_YEASTCAT5genetic
21623372
SWI6_YEASTSWI6genetic
27708008
ATC3_YEASTDRS2genetic
27708008
REI1_YEASTREI1genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
ACK1_YEASTACK1genetic
27708008
RTN2_YEASTRTN2genetic
27708008
YD018_YEASTYDR018Cgenetic
27708008
OCA6_YEASTOCA6genetic
27708008
DOS2_YEASTDOS2genetic
27708008
NUP42_YEASTNUP42genetic
27708008
RKM2_YEASTRKM2genetic
27708008
MSC2_YEASTMSC2genetic
27708008
IVY1_YEASTIVY1genetic
27708008
VHS1_YEASTVHS1genetic
27708008
DIN7_YEASTDIN7genetic
27708008
SEM1_YEASTSEM1genetic
27708008
ARO80_YEASTARO80genetic
27708008
DLDH_YEASTLPD1genetic
27708008
YFF2_YEASTYFL052Wgenetic
27708008
LSB3_YEASTLSB3genetic
27708008
THIK_YEASTPOT1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
NNK1_YEASTNNK1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
LIPB_YEASTLIP2genetic
27708008
GLRX8_YEASTGRX8genetic
27708008
YMK8_YEASTYML108Wgenetic
27708008
RAD14_YEASTRAD14genetic
27708008
OCA2_YEASTOCA2genetic
27708008
APP1_YEASTAPP1genetic
27708008
ATG3_YEASTATG3genetic
27708008
NOP12_YEASTNOP12genetic
27708008
TRM11_YEASTTRM11genetic
27708008
KTR1_YEASTKTR1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
RAX1_YEASTRAX1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
NUM1_YEASTNUM1genetic
27811238
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTHR2_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory