DOS2_YEAST - dbPTM
DOS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOS2_YEAST
UniProt AC P54858
Protein Name Protein DOS2
Gene Name DOS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 310
Subcellular Localization
Protein Description Acts in ubiquitin metabolism and is necessary for the control of single-copy DNA replication..
Protein Sequence MEFFYEEQVACIEDDKISNSHTKETGSTENTENNELQSRDDKTNEAFQKLEEEVNKRYEKTTSAFKKLVIEKDDGIEINLPISNETTETAQKYLKKLDENIHSVESLAQSYWSKMKTKNFWSGFSSFDNAAENDSNDKDENSKENEIAVGGNRTEAELRTLSKDKSVYLDNKMDLQLDPFDVDEKTEEICSILQGDKDISKLMNDIVPHKISYKDFWHIYFLQRNKILDKESKRKEILSKKEKETEEKEVEWDDEEEEEDDDKVEAVADNKSKGETKVAVSQEGLKDVSDHVGLANKDESKDDDDDDDWE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationCIEDDKISNSHTKET
EEECCCCCCCCCCCC		37.7130377154
25PhosphorylationSNSHTKETGSTENTE
CCCCCCCCCCCCCCC		37.6822369663
27PhosphorylationSHTKETGSTENTENN
CCCCCCCCCCCCCCC		39.7122369663
28PhosphorylationHTKETGSTENTENNE
CCCCCCCCCCCCCCC		34.3022369663
31PhosphorylationETGSTENTENNELQS
CCCCCCCCCCCCCCC		33.5822369663
38PhosphorylationTENNELQSRDDKTNE
CCCCCCCCCCHHHHH		50.7522369663
42UbiquitinationELQSRDDKTNEAFQK
CCCCCCHHHHHHHHH		58.5023749301
43PhosphorylationLQSRDDKTNEAFQKL
CCCCCHHHHHHHHHH		45.3321440633
562-HydroxyisobutyrylationKLEEEVNKRYEKTTS
HHHHHHHHHHHHHHH		62.63-
63PhosphorylationKRYEKTTSAFKKLVI
HHHHHHHHHHHHHEE		36.6228889911
66AcetylationEKTTSAFKKLVIEKD
HHHHHHHHHHEEECC		44.9325381059
103PhosphorylationKLDENIHSVESLAQS
HHHHHHHCHHHHHHH		24.6322369663
106PhosphorylationENIHSVESLAQSYWS
HHHHCHHHHHHHHHH		27.1822369663
110PhosphorylationSVESLAQSYWSKMKT
CHHHHHHHHHHCCCC		23.9822369663
111PhosphorylationVESLAQSYWSKMKTK
HHHHHHHHHHCCCCC		11.1322369663
113PhosphorylationSLAQSYWSKMKTKNF
HHHHHHHHCCCCCCC		18.0322369663
122PhosphorylationMKTKNFWSGFSSFDN
CCCCCCCCCCCCCCH		26.3122369663
125PhosphorylationKNFWSGFSSFDNAAE
CCCCCCCCCCCHHHH		33.3522369663
126PhosphorylationNFWSGFSSFDNAAEN
CCCCCCCCCCHHHHC		34.0722369663
135PhosphorylationDNAAENDSNDKDENS
CHHHHCCCCCCCCCC		59.5221440633
142PhosphorylationSNDKDENSKENEIAV
CCCCCCCCCCCCEEE		39.0222369663
191PhosphorylationEKTEEICSILQGDKD
HHHHHHHHHHCCCHH		31.8127214570
272PhosphorylationEAVADNKSKGETKVA
HHHHCCCCCCCEEEE		52.7429136822
276PhosphorylationDNKSKGETKVAVSQE
CCCCCCCEEEEECHH		39.2129136822
281PhosphorylationGETKVAVSQEGLKDV
CCEEEEECHHHHCCH		16.8722369663
289PhosphorylationQEGLKDVSDHVGLAN
HHHHCCHHHHCCCCC		31.9421551504
300PhosphorylationGLANKDESKDDDDDD
CCCCCCCCCCCCCCC		52.0619779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KRE2_YEASTKRE2physical
16429126
DOS2_YEASTDOS2physical
18467557
YMP0_YEASTYMR010Wphysical
18467557
AUR1_YEASTAUR1physical
18467557
YEH2_YEASTYEH2physical
18467557
TVP15_YEASTTVP15physical
18467557
RBD2_YEASTRBD2physical
18467557
AKR1_YEASTAKR1physical
18467557
DNM1_YEASTDNM1physical
18467557
DOS2_YEASTDOS2physical
22615397
NPR3_YEASTNPR3genetic
27708008
MTC1_YEASTMTC1genetic
27708008
HIR2_YEASTHIR2genetic
27708008
RUD3_YEASTRUD3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281, AND MASSSPECTROMETRY.

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