KRE2_YEAST - dbPTM
KRE2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KRE2_YEAST
UniProt AC P27809
Protein Name Glycolipid 2-alpha-mannosyltransferase
Gene Name KRE2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 442
Subcellular Localization Golgi apparatus membrane
Single-pass type II membrane protein.
Protein Description Mannosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for the attachment of the third mannose residue of O-linked saccharides..
Protein Sequence MALFLSKRLLRFTVIAGAVIVLLLTLNSNSRTQQYIPSSISAAFDFTSGSISPEQQVISEENDAKKLEQSALNSEASEDSEAMDEESKALKAAAEKADAPIDTKTTMDYITPSFANKAGKPKACYVTLVRNKELKGLLSSIKYVENKINKKFPYPWVFLNDEPFTEEFKEAVTKAVSSEVKFGILPKEHWSYPEWINQTKAAEIRADAATKYIYGGSESYRHMCRYQSGFFWRHELLEEYDWYWRVEPDIKLYCDINYDVFKWMQENEKVYGFTVSIHEYEVTIPTLWQTSMDFIKKNPEYLDENNLMSFLSNDNGKTYNLCHFWSNFEIANLNLWRSPAYREYFDTLDHQGGFFYERWGDAPVHSIAAALFLPKDKIHYFSDIGYHHPPYDNCPLDKEVYNSNNCECDQGNDFTFQGYSCGKEYYDAQGLVKPKNWKKFRE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Acetylation-MALFLSKRLLRFTV
-CCHHHCHHHHHHHH		49.5725381059
66UbiquitinationSEENDAKKLEQSALN
CCHHHHHHHHHHHHH		60.0023749301
88AcetylationEAMDEESKALKAAAE
HHCHHHHHHHHHHHH		62.1024489116
96UbiquitinationALKAAAEKADAPIDT
HHHHHHHHCCCCCCC		47.0023749301
135AcetylationLVRNKELKGLLSSIK
EECCHHHHHHHHHHH		48.9124489116
142AcetylationKGLLSSIKYVENKIN
HHHHHHHHHHHHHCC		45.2324489116
150UbiquitinationYVENKINKKFPYPWV
HHHHHCCCCCCCCEE		60.3017644757
151UbiquitinationVENKINKKFPYPWVF
HHHHCCCCCCCCEEE		47.2717644757
169UbiquitinationEPFTEEFKEAVTKAV
CCCCHHHHHHHHHHH		48.3017644757
174UbiquitinationEFKEAVTKAVSSEVK
HHHHHHHHHHCCCCC		39.9417644757
197N-linked_GlycosylationWSYPEWINQTKAAEI
CCCHHHHHHCHHHHH		44.541550992
211UbiquitinationIRADAATKYIYGGSE
HCHHCCCCEECCCCH		25.5623749301
211AcetylationIRADAATKYIYGGSE
HCHHCCCCEECCCCH		25.5624489116
251UbiquitinationWRVEPDIKLYCDINY
EECCCCEEEEEEECC		40.5617644757
262UbiquitinationDINYDVFKWMQENEK
EECCCHHHHHHHCCC		41.4217644757
297AcetylationTSMDFIKKNPEYLDE
HHHHHHHHCHHHCCC		73.2924489116
433AcetylationYDAQGLVKPKNWKKF
ECCCCCCCCCCHHHH		56.1524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KRE2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KRE2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KRE2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ILM1_YEASTILM1genetic
16269340
GWT1_YEASTGWT1genetic
16269340
VPS74_YEASTVPS74physical
18410729
VPS74_YEASTVPS74physical
18635803
SMI1_YEASTSMI1genetic
23891562
ATC1_YEASTPMR1genetic
23891562
GPI7_YEASTLAS21genetic
23891562
GUP1_YEASTGUP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
VPS21_YEASTVPS21genetic
23891562
SVP26_YEASTSVP26physical
24585773
ENV10_YEASTENV10genetic
27708008
RAD14_YEASTRAD14genetic
27708008
KPC1_YEASTPKC1genetic
27708008
GPI11_YEASTGPI11genetic
27708008
GNA1_YEASTGNA1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
GWT1_YEASTGWT1genetic
27708008
CFT2_YEASTCFT2genetic
27708008
VPS8_YEASTVPS8genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MAF1_YEASTMAF1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
HXKB_YEASTHXK2genetic
27708008
YG3O_YEASTYGR153Wgenetic
27708008
SMI1_YEASTSMI1genetic
27708008
AIM17_YEASTAIM17genetic
27708008
ARP1_YEASTARP1genetic
27708008
YJ66_YEASTYJR096Wgenetic
27708008
ELM1_YEASTELM1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
INO4_YEASTINO4genetic
27708008
SFL1_YEASTSFL1genetic
27708008
PEX27_YEASTPEX27genetic
27708008
AIM44_YEASTAIM44genetic
27708008
PPQ1_YEASTPPQ1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KRE2_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycosylation in Saccharomyces cerevisiae: cloning andcharacterization of an alpha-1,2-mannosyltransferase structuralgene.";
Haeusler A., Robbins P.W.;
Glycobiology 2:77-84(1992).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, ANDGLYCOSYLATION AT ASN-197.

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