YEH2_YEAST - dbPTM
YEH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YEH2_YEAST
UniProt AC Q07950
Protein Name Sterol esterase 2
Gene Name YEH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 538
Subcellular Localization Cell membrane
Single-pass type II membrane protein .
Protein Description Mediates the hydrolysis of steryl esters. Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism..
Protein Sequence MVNKVVDEVQRLVSAIILTSFMTGLFILSLWKNYVTVHFQHKNDPRDTRSSRTKIQPNDKKKKRPARHSRPLSISSTTPLDLQRDQENNIEYDRTVTSKLSMTSNASLSENGDGNANIKMETNVNQAPYAAENPFQNIALAEDTKLVPDLKYYYKEYGIDIEEFEVETDDGFIIDLWHFKSRLNDGVEEVKREPILLLHGLLQSCGAFASSGRKSLAYFLYESGFDVWLGNNRCGLNAKWNMKKLGNDHSKKWDWDMHQMVQYDLKALINYVLDSTGYAKLSLVAHSQGTTQGFMGLVNGEKLYASDFKLVDKLENFVALAPAVYPGPLLDEKAFVRLMAKGIDSPWYFGRRSFIPLMMTMRKLMVGTKIFSFLSYIMFNYLFDWNDVLWDRVLRDRNFLFSPVHISVKLMQWWLSPLPNKLSFKKGAEKIFPDKKTWFPIAKNDDDSGNNLDNNKLHLNPKRQNSEEFPHIIMFIPKQDRLVDGERLINHFINHEANAVYKIWYIDEYSHLDVLWAHDVIDRIGKPMIENLRFPNAR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
69PhosphorylationKKRPARHSRPLSISS
CCCCCCCCCCCCCCC		30.0022890988
73PhosphorylationARHSRPLSISSTTPL
CCCCCCCCCCCCCCC		24.0917330950
75PhosphorylationHSRPLSISSTTPLDL
CCCCCCCCCCCCCCC		20.4625533186
76PhosphorylationSRPLSISSTTPLDLQ
CCCCCCCCCCCCCCC		34.3317330950
77PhosphorylationRPLSISSTTPLDLQR
CCCCCCCCCCCCCCC		26.1622890988
78PhosphorylationPLSISSTTPLDLQRD
CCCCCCCCCCCCCCC		24.6522890988
101PhosphorylationRTVTSKLSMTSNASL
CHHHEEEEECCCCCC		24.6119795423
103PhosphorylationVTSKLSMTSNASLSE
HHEEEEECCCCCCCC		18.5619779198
104PhosphorylationTSKLSMTSNASLSEN
HEEEEECCCCCCCCC		23.0420377248
107PhosphorylationLSMTSNASLSENGDG
EEECCCCCCCCCCCC		36.3628152593
109PhosphorylationMTSNASLSENGDGNA
ECCCCCCCCCCCCCC		26.9020377248
191UbiquitinationNDGVEEVKREPILLL
CCCHHHHHHCHHHHH		55.0823749301
353PhosphorylationPWYFGRRSFIPLMMT
CCCCCCHHHHHHHHH		26.6030377154
360PhosphorylationSFIPLMMTMRKLMVG
HHHHHHHHHHHHHHH		10.3930377154
363AcetylationPLMMTMRKLMVGTKI
HHHHHHHHHHHHHHH		30.0725381059
443UbiquitinationKTWFPIAKNDDDSGN
CCEEEEECCCCCCCC		62.7223749301
448PhosphorylationIAKNDDDSGNNLDNN
EECCCCCCCCCCCCC		50.8725521595
456AcetylationGNNLDNNKLHLNPKR
CCCCCCCCCCCCCCC		43.4624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YEH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YEH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YEH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUR1_YEASTSUR1genetic
21623372
ERG2_YEASTERG2genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ASK10_YEASTASK10genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
NU188_YEASTNUP188genetic
27708008
NTH2_YEASTNTG2genetic
27708008
RAD1_YEASTRAD1genetic
27708008
THRC_YEASTTHR4genetic
27708008
TRM3_YEASTTRM3genetic
27708008
TPS2_YEASTTPS2genetic
27708008
SPO71_YEASTSPO71genetic
27708008
LSM6_YEASTLSM6genetic
27708008
PUR3_YEASTADE8genetic
27708008
MSRA_YEASTMXR1genetic
27708008
KIP3_YEASTKIP3genetic
27708008
EFM5_YEASTAML1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
PSD10_YEASTNAS6genetic
27708008
YPT7_YEASTYPT7genetic
27708008
YMP8_YEASTYMR018Wgenetic
27708008
KAR5_YEASTKAR5genetic
27708008
YM01_YEASTYMR111Cgenetic
27708008
GBLP_YEASTASC1genetic
27708008
RE114_YEASTREC114genetic
27708008
YO087_YEASTDUF1genetic
27708008
MSB4_YEASTMSB4genetic
27708008
PT127_YEASTPET127genetic
27708008
SFL1_YEASTSFL1genetic
27708008
SYC1_YEASTSYC1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
ASR1_YEASTASR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YEH2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-75 AND SER-76,AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.

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