dbPTM

EFM5_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EFM5_YEAST
UniProt AC	P53200
Protein Name	Protein-lysine N-methyltransferase EFM5 {ECO:0000255\|HAMAP-Rule:MF_03187, ECO:0000305\|PubMed:25446118}
Gene Name	EFM5 {ECO:0000255\|HAMAP-Rule:MF_03187, ECO:0000303\|PubMed:25446118}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	248
Subcellular Localization	Cytoplasm .
Protein Description	S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-79'. [PubMed: 25446118 Required for replication of Brome mosaic virus (BMV)]
Protein Sequence	MSDSDSDSDYELTLSANALAALEEFKREEQQHQEAFQKLYDETDEDFQKKKKEEGMKLFKEDWQLSQFWYSDDTAAILADAILEGADENTVIAIVSAPSVYAAIQKKPTNEIPTEHIYLFEFDKRFELLAGRDHFFFYDYNKPLDFSDEIKGKVDRLLIDPPFLNEDCQTKSSITAKCLLAPNDNSKTKKGVFKHRLISCTGERMSEVISKVYSDTRITTFLPEHSNGLSNEFRCYANFECSSWKFAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Phosphorylation	------MSDSDSDSD ------CCCCCCCCC	19795423
4	Phosphorylation	----MSDSDSDSDYE ----CCCCCCCCCCE	19795423
6	Phosphorylation	--MSDSDSDSDYELT --CCCCCCCCCCEEH	19795423
8	Phosphorylation	MSDSDSDSDYELTLS CCCCCCCCCCEEHHH	19795423
10	Phosphorylation	DSDSDSDYELTLSAN CCCCCCCCEEHHHHH	19795423
38	Acetylation	QHQEAFQKLYDETDE HHHHHHHHHHHCCHH	24489116
43	Phosphorylation	FQKLYDETDEDFQKK HHHHHHCCHHHHHHH	22369663
49	Acetylation	ETDEDFQKKKKEEGM CCHHHHHHHHHHHHH	24489116
124	Ubiquitination	IYLFEFDKRFELLAG EEEEEECHHHHHHCC	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EFM5_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EFM5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EFM5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG15_YEAST	ATG15	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
PRP9_YEAST	PRP9	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
APC5_YEAST	APC5	genetic	27708008
ASA1_YEAST	ASA1	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
ACA2_YEAST	CST6	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
PEP8_YEAST	PEP8	genetic	27708008
YJY1_YEAST	YJR011C	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
POM33_YEAST	POM33	genetic	27708008
UBI4P_YEAST	UBI4	genetic	27708008
SIC1_YEAST	SIC1	genetic	27708008
PEX13_YEAST	PEX13	genetic	27708008
COA4_YEAST	COA4	genetic	27708008
ORM2_YEAST	ORM2	genetic	27708008
TSA1_YEAST	TSA1	genetic	27708008
MUB1_YEAST	MUB1	genetic	27708008
SIN3_YEAST	SIN3	genetic	27708008
WHI5_YEAST	WHI5	genetic	27708008
PALA_YEAST	RIM20	genetic	27708008
HSP7F_YEAST	SSE1	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EFM5_YEAST

Related Literatures of Post-Translational Modification