TRM3_YEAST - dbPTM
TRM3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRM3_YEAST
UniProt AC Q07527
Protein Name tRNA (guanosine(18)-2'-O)-methyltransferase {ECO:0000305|PubMed:9917067}
Gene Name TRM3 {ECO:0000303|PubMed:9917067}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1436
Subcellular Localization Cytoplasm .
Protein Description S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs..
Protein Sequence MVGGALICKYLPREEQLKLISDLIQNDSLEEVLELIETSPLDITTDSNIETPIFEKITEQVIAYASIDGEAREMFRSSRAEMNKALRTSAQLLCCLPSVWHKFQVWMSYRLNDIISENYKHLFNDNFGKKIVQPFFDSFAEEQNANIKHENLHLDILSLLHYLEVVYLFDECKNGISSKCLDFIIVPLLGCNSEEIADSCSKLMRWHIKYLSKCCNTDSNFDKLIWTFIKQLYAEGSQQAWKQKNSLSFLLRFLLAAELSPELITYIKTDAYWRHIQTELDNDVHEHRKLALSILKLTIQKLSSHGITLQTTFYKCNDLANIEMLGSWKKFTTLYEMIALDTSLNQIQAAKQDIIKIFDNEHLHHSWGLILLSTGLKSSMESVRKYMMTLMFSITNMSAFSSNLPLLTKTLLPAAMSAHYFDVKGVSCPHGEKLSLFVNNLLSQTTEGISDILFEILKLLVEKGTSFDPSRIYLSYGILVFFQNNKQKTINSDHLSLIRKLYDFAAEEEVLETTIQTIYLKFLLYIDPSVSASELLFTLVSHIKLKGGTYKYVEPLFEDYRDLAVSHFDDLQAKENLTTNIGKDTIFDLLASIIFDFKDIDITPDFLIEVAKSKQDIPVYTSKAVTFLTQLLSGEPSNGYTYENATALLSYPNFTISTWKSINVNNLFKSVMEKFSLDKFKFFAEIYQKTYECRFDTIELNFNDLLSLYEMVKKSANQCSRESFKVKDSAYSSYFELLNTFLKTYALNRDSSEGNDDELHILLRLVDENINKDNGNYLGNLAVCKLLYFIIDSYIHCSTSVSDDDIFIVKFIFEKFSFIWECINSERLVLKERDLHLMLIKGLFHPVILYFGSNQYIDTLTSKLEEHAQTIISLSYSRRSLLPLLGSQLRVFMKFYGKLLREDVNYWWLINIIVGVFKQPQMDVNLYKLKPVISSLFDHKLNNYYIKGDELYEKVYGPDEILARVSIIDSILYANDQLKIRLIEKVTEKTNALYAIKRTDGAEALQRLLQWQLLLLSLLTTNEKKLSETSMIRILKSIEDESSPLVRVYKEWFISSKVVDYYKTGNPKFAEDYLFSLLEDHSKPVFVVSAEKICFMVLKDLRNDEKKYGFTQLLDRFICTLVPNAASNKPLVRHFSNSLIISLWPTFKAYLSDHTLRNIIENLYSNAKKTQIFGQYRAGDANIWDLKGDRKLTNMFGGVLKKVTDHDCPYISESVFEKYLQEKDIVPIGTDERSLWLDKRDTNTESVNNANISCDTSPLQTKSGAWETVLDLDNKKSNDVVTRSELIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGLEQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQHM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58PhosphorylationTPIFEKITEQVIAYA
CCHHHHHHHHHHHHH		31.2830377154
66PhosphorylationEQVIAYASIDGEARE
HHHHHHHCCCHHHHH		14.4530377154
120AcetylationDIISENYKHLFNDNF
HHHCHHHHHHHCCCC		45.4724489116
209AcetylationKLMRWHIKYLSKCCN
HHHHHHHHHHHHHCC		27.5322865919
393PhosphorylationYMMTLMFSITNMSAF
HHHHHHHHHHCHHHH		17.9730377154
395PhosphorylationMTLMFSITNMSAFSS
HHHHHHHHCHHHHHC		24.5419779198
408PhosphorylationSSNLPLLTKTLLPAA
HCCCCHHHHHHHHHH		29.6619779198
546AcetylationLVSHIKLKGGTYKYV
HHHHHCCCCCCEEEE		50.7425381059
947AcetylationKLNNYYIKGDELYEK
CCCCCEECHHHHHHH		44.1624489116
1107AcetylationDLRNDEKKYGFTQLL
HHCCCHHHCCHHHHH		48.8622865919
1187AcetylationDANIWDLKGDRKLTN
CCCCCCCCCCHHHHH		57.1824489116
1223AcetylationFEKYLQEKDIVPIGT
HHHHHCCCCCEECCC		39.5324489116
1256PhosphorylationNANISCDTSPLQTKS
CCCCEECCCCCCCCC		36.2530377154
1257PhosphorylationANISCDTSPLQTKSG
CCCEECCCCCCCCCC		15.4620377248
1261PhosphorylationCDTSPLQTKSGAWET
ECCCCCCCCCCHHEE		34.5621551504
1360PhosphorylationKEKKKEGYTLIGLEQ
HHHHCCCCEEEEEEE		10.2428889911
1361PhosphorylationEKKKEGYTLIGLEQT
HHHCCCCEEEEEEEC		23.8228889911
1368PhosphorylationTLIGLEQTDKSVKLD
EEEEEEECCCCEECC		35.7028889911
1417PhosphorylationQQFGVIRSMNIQTAT
HHHCHHHCCCCCCCE		12.6930377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRM3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRM3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRM3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRM3_YEASTTRM3physical
14759368
FAS1_YEASTFAS1physical
16429126
HSP77_YEASTSSC1physical
16429126
RIC1_YEASTRIC1genetic
19061648
UPF3_YEASTUPF3genetic
19061648
SYDM_YEASTMSD1genetic
19061648
PAT1_YEASTPAT1genetic
19061648
PES4_YEASTPES4genetic
19061648
MYO4_YEASTMYO4genetic
19061648
SAC3_YEASTSAC3genetic
19061648
NUP42_YEASTNUP42genetic
19061648
CWC21_YEASTCWC21genetic
19061648
HMT1_YEASTHMT1genetic
19061648
TRM7_YEASTTRM7genetic
19061648
RXT2_YEASTRXT2genetic
19061648
SIF2_YEASTSIF2genetic
19061648
EF1A_YEASTTEF2genetic
19061648
POP7_YEASTPOP7genetic
19061648
LSM1_YEASTLSM1genetic
19061648
NU188_YEASTNUP188genetic
19061648
ITT1_YEASTITT1genetic
19061648
H1_YEASTHHO1genetic
19061648
BRR1_YEASTBRR1genetic
19061648
YP174_YEASTYPR174Cgenetic
19061648
MGR1_YEASTMGR1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
SHE9_YEASTSHE9genetic
20093466
SLX8_YEASTSLX8genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
HXKB_YEASTHXK2genetic
20093466
ROM1_YEASTROM1genetic
20093466
GSH1_YEASTGSH1genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
PTM1_YEASTPTM1genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
VRP1_YEASTVRP1genetic
20093466
VAC14_YEASTVAC14genetic
20093466
AIM34_YEASTAIM34genetic
20093466
JNM1_YEASTJNM1genetic
20093466
RHO2_YEASTRHO2genetic
20093466
DGK1_YEASTDGK1genetic
20093466
CYPH_YEASTCPR1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
SHE9_YEASTSHE9genetic
27708008
UBP3_YEASTUBP3genetic
27708008
HXKB_YEASTHXK2genetic
27708008
YJH0_YEASTYJL070Cgenetic
27708008
GSH1_YEASTGSH1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DCOR_YEASTSPE1genetic
27708008
TRS33_YEASTTRS33genetic
29674565
ATC7_YEASTNEO1genetic
29674565
MDM10_YEASTMDM10genetic
29674565
ALG14_YEASTALG14genetic
29674565
SAC3_YEASTSAC3genetic
29674565
PT122_YEASTPET122genetic
29674565
NBP35_YEASTNBP35genetic
29674565
HUR1_YEASTHUR1genetic
29674565
ELM1_YEASTELM1genetic
29674565
RIC1_YEASTRIC1genetic
29674565
DSE3_YEASTDSE3genetic
29674565
KAR3_YEASTKAR3genetic
29674565
ELG1_YEASTELG1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRM3_YEAST

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Related Literatures of Post-Translational Modification

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