dbPTM

ITT1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ITT1_YEAST
UniProt AC	Q04638
Protein Name	Translation termination inhibitor protein ITT1
Gene Name	ITT1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	464
Subcellular Localization
Protein Description	Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA..
Protein Sequence	MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHGYNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCYGRLFEGMPGTET

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	MYPELEMKSVKVEEE HCHHHEEEEEEEEEC	42.60	23749301
151	Ubiquitination	LFPNGIRKCLTQDQY HCCCHHHHHCCHHHH	31.51	23749301
172	Ubiquitination	SEEATLQKVSRSNYH CHHHHHHHHHHCCCC	45.34	23749301
288	Ubiquitination	QAATRLSKYCPYACV HHHHHHHHHCCCEEE	56.30	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ITT1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ITT1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ITT1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNF11_YEAST	SNF11	physical	10688190
ERF3_YEAST	SUP35	physical	11570975
ERF1_YEAST	SUP45	physical	11570975
RIC1_YEAST	RIC1	genetic	19061648
POP8_YEAST	POP8	genetic	19061648
PFD5_YEAST	GIM5	genetic	19061648
SYKM_YEAST	MSK1	genetic	19061648
SYDM_YEAST	MSD1	genetic	19061648
PAT1_YEAST	PAT1	genetic	19061648
RMP1_YEAST	RMP1	genetic	19061648
RKM2_YEAST	RKM2	genetic	19061648
CWC21_YEAST	CWC21	genetic	19061648
SHE3_YEAST	SHE3	genetic	19061648
NGR1_YEAST	NGR1	genetic	19061648
LTV1_YEAST	LTV1	genetic	19061648
PAN3_YEAST	PAN3	genetic	19061648
CSK22_YEAST	CKA2	genetic	19061648
NCBP1_YEAST	STO1	genetic	19061648
PUS1_YEAST	PUS1	genetic	19061648
YP174_YEAST	YPR174C	genetic	19061648
SLX5_YEAST	SLX5	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
ARI1_YEAST	ARI1	genetic	27708008
SODM_YEAST	SOD2	genetic	27708008
RM49_YEAST	MRP49	genetic	27708008
ACE2_YEAST	ACE2	genetic	27708008
PSY3_YEAST	PSY3	genetic	27708008
PDR5_YEAST	PDR5	genetic	27708008
FUMH_YEAST	FUM1	genetic	27708008
MDL2_YEAST	MDL2	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
ATG13_YEAST	ATG13	genetic	27708008
CCD33_HUMAN	CCDC33	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ITT1_YEAST

Related Literatures of Post-Translational Modification