PSY3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSY3_YEAST
• UniProt AC: Q12318
• Protein Name: Platinum sensitivity protein 3
• Gene Name: PSY3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 242
• Subcellular Localization: Nucleus .
• Protein Description: Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway..
• Protein Sequence: MEVLKNIRIYPLSNFITSTKNYINLPNELRNLISEEQESKLGFLHIIESDFKPSVALQKLVNCTTGDEKILIIDIVSIWSQQKQRQHGAIYMNSLSCINITGLIVFLELLYDSPMDALRRCQVDNFNFQLRGIVIDNLSFLNFESDKNYDVINLSKFEKLFKILRKLREFLGCWIITKSFPTDFYNGIENTLVDKWSIKRKSGVTLYPTKLPDSYMKGMDLIIYREVVDGRPQYRRIAALEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
202	Phosphorylation	KWSIKRKSGVTLYPT CCCEECCCCCEEEEC	42.39	28889911
205	Phosphorylation	IKRKSGVTLYPTKLP EECCCCCEEEECCCC	24.89	19779198
215	Phosphorylation	PTKLPDSYMKGMDLI ECCCCCHHHCCCEEE	15.38	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSY3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSY3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSY3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSM2_YEAST	CSM2	physical	11283351
RAD18_YEAST	RAD18	genetic	12149442
RAD14_YEAST	RAD14	genetic	12149442
RAD9_YEAST	RAD9	genetic	12149442
RAD24_YEAST	RAD24	genetic	12149442
LSM6_YEAST	LSM6	genetic	17314980
SWR1_YEAST	SWR1	genetic	17314980
SERB_YEAST	SER2	genetic	17314980
SPT3_YEAST	SPT3	genetic	17314980
DPOD3_YEAST	POL32	genetic	17314980
PUS3_YEAST	DEG1	genetic	17314980
SAW1_YEAST	SAW1	genetic	17314980
CBF3B_YEAST	CEP3	physical	18719252
CSM2_YEAST	CSM2	physical	18719252
DPOZ_YEAST	REV3	genetic	19496932
SRS2_YEAST	SRS2	genetic	19496932
RAD9_YEAST	RAD9	genetic	19496932
RV161_YEAST	RVS161	genetic	18931302
SNT1_YEAST	SNT1	genetic	18931302
STE50_YEAST	STE50	genetic	20093466
PAC11_YEAST	PAC11	genetic	20093466
RIM15_YEAST	RIM15	genetic	20093466
ZRT1_YEAST	ZRT1	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
ASK10_YEAST	ASK10	genetic	20093466
ACA2_YEAST	CST6	genetic	20093466
FEN1_YEAST	RAD27	genetic	20093466
EF1G2_YEAST	TEF4	genetic	20093466
HMX1_YEAST	HMX1	genetic	20093466
MSN2_YEAST	MSN2	genetic	20093466
PP2C1_YEAST	PTC1	genetic	21127252
KCS1_YEAST	KCS1	genetic	21127252
RAD51_YEAST	RAD51	genetic	21127252
SHU2_YEAST	SHU2	genetic	17206143
CLA4_YEAST	CLA4	genetic	17206143
SLX4_YEAST	SLX4	genetic	17206143
CSM2_YEAST	CSM2	physical	22465956
CSM2_YEAST	CSM2	physical	22749910
DPOZ_YEAST	REV3	genetic	24339919
SRS2_YEAST	SRS2	genetic	24339919
CSM2_YEAST	CSM2	physical	23575680
RAD51_YEAST	RAD51	physical	23575680
GPR1_YEAST	GPR1	genetic	27708008
RMI1_YEAST	RMI1	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
DPOD3_YEAST	POL32	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
FEN1_YEAST	RAD27	genetic	27708008
VAM3_YEAST	VAM3	genetic	27708008
RAD51_YEAST	RAD51	physical	26215801
RFA2_YEAST	RFA2	physical	26215801
CSM2_YEAST	CSM2	physical	29069504
SHU1_YEAST	SHU1	physical	29069504
SHU2_YEAST	SHU2	physical	29069504
GOGA2_HUMAN	GOLGA2	physical	27107014
LDOC1_HUMAN	LDOC1	physical	27107014
ZFHX3_HUMAN	ZFHX3	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.