dbPTM

ZFHX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZFHX3_HUMAN
UniProt AC	Q15911
Protein Name	Zinc finger homeobox protein 3
Gene Name	ZFHX3
Organism	Homo sapiens (Human).
Sequence Length	3703
Subcellular Localization	Nucleus . Cytoplasm . Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
Protein Description	Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. [PubMed: 25105025 Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression]
Protein Sequence	MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFASLQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGKQGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGPGHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVLQTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILPSASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLGNPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEAIQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPLLPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEGCDSPVVSGKD --CCCCCCCCCCCCC	24.54	29255136
10	Phosphorylation	GCDSPVVSGKDNGCG CCCCCCCCCCCCCCC	40.12	29255136
35	Acetylation	NSTHLPDKPSSMEQS CCCCCCCCCCCCCCC	44.88	26051181
219	O-linked_Glycosylation	DQAFPNTSALAGLSP CCCCCCHHHHCCCCH	28.11	30059200
252	Ubiquitination	LNSDGSAKSSCVSKD CCCCCCCCCHHCCCC	44.60	-
258	Acetylation	AKSSCVSKDVPNNVD CCCHHCCCCCCCCCC	42.20	26051181
258	Ubiquitination	AKSSCVSKDVPNNVD CCCHHCCCCCCCCCC	42.20	-
267	Phosphorylation	VPNNVDLSKFDGFVL CCCCCCHHHCCCEEE	27.15	22817900
275	Phosphorylation	KFDGFVLYGKRKPIL HCCCEEECCCCCCHH	18.46	24260401
293	Phosphorylation	LCKLSFGYVRSFVTH HHHCCHHHHHHHHHH	7.23	-
323	Phosphorylation	ILSNKNISAIIQGIG HHHCCCHHHHHCCCC	23.86	-
353	O-linked_Glycosylation	NFQHPLVSTANLIGP CCCCCCCEECCEECC	29.50	30059200
354	O-linked_Glycosylation	FQHPLVSTANLIGPG CCCCCCEECCEECCC	16.46	30059200
365	Phosphorylation	IGPGHSFYGKFSGIR ECCCCCCCCCCCCCE	23.56	28555341
369	Phosphorylation	HSFYGKFSGIRMEGE CCCCCCCCCCEECCC	36.47	24719451
399	Phosphorylation	AGLLTPSTLLNLGGL CCCCCHHHHHHCCCC	36.15	24173317
413	Phosphorylation	LTSSVLKTPITSVPL CCHHHCCCCCCCCCC	18.76	23403867
416	Phosphorylation	SVLKTPITSVPLGPL HHCCCCCCCCCCCCC	25.52	23403867
417	Phosphorylation	VLKTPITSVPLGPLA HCCCCCCCCCCCCCC	23.58	23663014
425	Phosphorylation	VPLGPLASSPTKSSE CCCCCCCCCCCCCCC	44.53	30266825
426	Phosphorylation	PLGPLASSPTKSSEG CCCCCCCCCCCCCCC	30.86	30266825
428	Phosphorylation	GPLASSPTKSSEGKD CCCCCCCCCCCCCCC	45.57	30266825
430	Phosphorylation	LASSPTKSSEGKDSG CCCCCCCCCCCCCCC	35.78	23663014
431	Phosphorylation	ASSPTKSSEGKDSGA CCCCCCCCCCCCCCC	52.50	23663014
434	Acetylation	PTKSSEGKDSGAAEG CCCCCCCCCCCCCCC	44.67	26051181
436	Phosphorylation	KSSEGKDSGAAEGEK CCCCCCCCCCCCCCC	33.54	30177828
497	Phosphorylation	GCKGLFPSELDEELE CCCCCCCHHHCHHHH	43.38	23186163
517	Phosphorylation	EPGAAAGSSSKKDLA CCCCCCCCCCHHHHH	27.06	23186163
518	Phosphorylation	PGAAAGSSSKKDLAL CCCCCCCCCHHHHHH	45.30	23186163
519	Phosphorylation	GAAAGSSSKKDLALS CCCCCCCCHHHHHHC	45.48	23186163
526	Phosphorylation	SKKDLALSNQSISNS CHHHHHHCCCCCCCC	27.50	22199227
529	Phosphorylation	DLALSNQSISNSPLM HHHHCCCCCCCCCCC	32.03	22199227
531	Phosphorylation	ALSNQSISNSPLMPN HHCCCCCCCCCCCHH	36.18	22199227
533	Phosphorylation	SNQSISNSPLMPNVL CCCCCCCCCCCHHHH	16.78	22199227
542	Phosphorylation	LMPNVLQTLSRGTAS CCHHHHHHHHCCCCC	23.65	29978859
544	Phosphorylation	PNVLQTLSRGTASTS HHHHHHHHCCCCCCC	31.86	29978859
571	O-linked_Glycosylation	ANRRNRLSFNSEGVR CCCCCCCCCCCCCCE	21.10	30059200
571	Phosphorylation	ANRRNRLSFNSEGVR CCCCCCCCCCCCCCE	21.10	25159151
574	O-linked_Glycosylation	RNRLSFNSEGVRANV CCCCCCCCCCCEEHH	33.44	30059200
574	Phosphorylation	RNRLSFNSEGVRANV CCCCCCCCCCCEEHH	33.44	29523821
647	Phosphorylation	VECPKCDTVLGSSRS CCCCCCCEEECCCCC	27.40	-
651	Phosphorylation	KCDTVLGSSRSLGGH CCCEEECCCCCCCCH	20.58	22210691
654	Phosphorylation	TVLGSSRSLGGHMTM EEECCCCCCCCHHHH	33.06	23403867
664	Phosphorylation	GHMTMMHSRNSCKTL CHHHHEECCCCCCCC	18.43	22210691
670	Phosphorylation	HSRNSCKTLKCPKCN ECCCCCCCCCCCCCC	35.46	22210691
718	Phosphorylation	PRLARGESYTCGYKP CCCCCCCCCCCCCCC	28.68	28857561
724	Acetylation	ESYTCGYKPFRCEVC CCCCCCCCCEEEEEC	23.98	26051181
742	Phosphorylation	TTTKGNLSIHMQSDK CCCCCCEEEEECCCH	17.91	28555341
794	Phosphorylation	SSSCGAPSPTKPKTK HHHCCCCCCCCCCCC	44.67	21406692
796	Phosphorylation	SCGAPSPTKPKTKPT HCCCCCCCCCCCCCC	65.40	21406692
924	Phosphorylation	LGGGQLVSEELMNLG CCCCHHCCHHHHHHC	33.67	24043423
933	Phosphorylation	ELMNLGESFIQTNDP HHHHHCHHHHHCCCC	26.33	24043423
937	Phosphorylation	LGESFIQTNDPSLKL HCHHHHHCCCCCCHH	36.45	28634120
941	Phosphorylation	FIQTNDPSLKLFQCA HHHCCCCCCHHHEEH	40.79	28634120
970	Phosphorylation	LHMNVERSLSEDEWK CCCCHHCCCCHHHHH	23.81	21815630
972	Phosphorylation	MNVERSLSEDEWKAV CCHHCCCCHHHHHHH	44.22	26270265
1115	Phosphorylation	RSMKHQRSESLRKLQ HHCCHHHHHHHHHHH	25.60	-
1117	Phosphorylation	MKHQRSESLRKLQRL CCHHHHHHHHHHHHH	34.42	-
1126	Ubiquitination	RKLQRLQKGLPEEDE HHHHHHHHCCCCCCC	67.99	-
1140	Phosphorylation	EDLGQIFTIRRCPST CCHHHHEEEEECCCC	18.40	26074081
1146	Phosphorylation	FTIRRCPSTDPEEAI EEEEECCCCCHHHHH	49.41	25849741
1147	Phosphorylation	TIRRCPSTDPEEAIE EEEECCCCCHHHHHH	40.49	30266825
1160	Phosphorylation	IEDVEGPSETAADPE HHCCCCCCCCCCCHH	59.44	30266825
1162	Phosphorylation	DVEGPSETAADPEEL CCCCCCCCCCCHHHH	31.33	30266825
1178	Phosphorylation	KDQEGGASSSQAEKE HCCCCCCCCHHHHHH	33.52	22210691
1179	Phosphorylation	DQEGGASSSQAEKEL CCCCCCCCHHHHHHH	26.40	22210691
1180	Phosphorylation	QEGGASSSQAEKELT CCCCCCCHHHHHHHC	30.80	17525332
1187	Phosphorylation	SQAEKELTDSPATSK HHHHHHHCCCCCCCC	35.21	30266825
1189	Phosphorylation	AEKELTDSPATSKRI HHHHHCCCCCCCCCC	15.93	25849741
1192	Phosphorylation	ELTDSPATSKRISFP HHCCCCCCCCCCCCC	37.86	30266825
1193	Phosphorylation	LTDSPATSKRISFPG HCCCCCCCCCCCCCC	23.26	30266825
1197	Phosphorylation	PATSKRISFPGSSES CCCCCCCCCCCCCCC	29.44	25159151
1201	Phosphorylation	KRISFPGSSESPLSS CCCCCCCCCCCCCCC	31.04	30266825
1202	Phosphorylation	RISFPGSSESPLSSK CCCCCCCCCCCCCCC	48.27	30266825
1204	Phosphorylation	SFPGSSESPLSSKRP CCCCCCCCCCCCCCC	32.84	30266825
1207	Phosphorylation	GSSESPLSSKRPKTA CCCCCCCCCCCCCCH	36.88	29255136
1208	Phosphorylation	SSESPLSSKRPKTAE CCCCCCCCCCCCCHH	40.13	29255136
1223	Phosphorylation	EIKPEQMYQCPYCKY HCCHHHHCCCCCCCC	13.47	25599653
1227	Phosphorylation	EQMYQCPYCKYSNAD HHHCCCCCCCCCCCC	14.81	25599653
1229	Acetylation	MYQCPYCKYSNADVN HCCCCCCCCCCCCHH	45.96	26051181
1230	Phosphorylation	YQCPYCKYSNADVNR CCCCCCCCCCCCHHH	12.00	25599653
1231	Phosphorylation	QCPYCKYSNADVNRL CCCCCCCCCCCHHHH	15.84	25599653
1244	Phosphorylation	RLRVHAMTQHSVQPM HHHHEEHHHCCCCHH	24.74	28464451
1247	Phosphorylation	VHAMTQHSVQPMLRC HEEHHHCCCCHHHCC	16.78	28464451
1298	Phosphorylation	TPEMVMPSSMFLPAA CHHHHCCHHHCCCCC	19.15	24719451
1299	Phosphorylation	PEMVMPSSMFLPAAV HHHHCCHHHCCCCCC	14.00	24719451
1325	Phosphorylation	AGKQPETSEDLGKNI CCCCCCCCHHHHHCC	27.70	21815630
1335	Phosphorylation	LGKNILPSASTEQSG HHHCCCCCCCCCCCC	31.26	29978859
1337	Phosphorylation	KNILPSASTEQSGDL HCCCCCCCCCCCCCC	36.49	29978859
1338	Phosphorylation	NILPSASTEQSGDLK CCCCCCCCCCCCCCC	37.45	29978859
1341	Phosphorylation	PSASTEQSGDLKPSP CCCCCCCCCCCCCCC	28.21	29978859
1347	Phosphorylation	QSGDLKPSPADPGSV CCCCCCCCCCCCCCC	31.00	25850435
1353	Phosphorylation	PSPADPGSVREDSGF CCCCCCCCCCCCCCE	24.32	25850435
1358	Phosphorylation	PGSVREDSGFICWKK CCCCCCCCCEEEECC	30.74	29978859
1394	Phosphorylation	KRPQLPVSDRHVYKY CCCCCCCCCCCEEEE	27.30	25159151
1420	Phosphorylation	IEKLQLHSQYHVIRA HHHHHHHCHHHHHHH	40.81	26074081
1422	Phosphorylation	KLQLHSQYHVIRAAT HHHHHCHHHHHHHHH	10.89	26074081
1497	Phosphorylation	EEDKEEESDLEDKQS CCCCCCCCCCCCCCC	51.26	21815630
1504	Phosphorylation	SDLEDKQSPTGSDSG CCCCCCCCCCCCCCC	30.12	23312004
1506	Phosphorylation	LEDKQSPTGSDSGSV CCCCCCCCCCCCCCC	55.34	23312004
1508	Phosphorylation	DKQSPTGSDSGSVQE CCCCCCCCCCCCCCC	30.95	23312004
1510	Phosphorylation	QSPTGSDSGSVQEDS CCCCCCCCCCCCCCC	34.36	23312004
1512	Phosphorylation	PTGSDSGSVQEDSGS CCCCCCCCCCCCCCC	25.28	23312004
1517	Phosphorylation	SGSVQEDSGSEPKRA CCCCCCCCCCCCCCC	43.39	23312004
1519	Phosphorylation	SVQEDSGSEPKRALP CCCCCCCCCCCCCCC	55.46	23312004
1534	Phosphorylation	FRKGPNFTMEKFLDP CCCCCCCCHHHHCCC	30.94	24144214
1580	Phosphorylation	LKRALQESATGQPEP HHHHHHHHHCCCCCC	20.40	24732914
1582	Phosphorylation	RALQESATGQPEPTS HHHHHHHCCCCCCCC	45.70	24732914
1588	Phosphorylation	ATGQPEPTSSPDNKP HCCCCCCCCCCCCCC	39.93	30266825
1589	Phosphorylation	TGQPEPTSSPDNKPF CCCCCCCCCCCCCCC	51.06	30266825
1590	Phosphorylation	GQPEPTSSPDNKPFK CCCCCCCCCCCCCCC	38.46	30266825
1594	Acetylation	PTSSPDNKPFKCNTC CCCCCCCCCCCCCCC	60.25	26051181
1721	Phosphorylation	KLADMIASRQQQQQQ HHHHHHHHHHHHHHH	21.50	-
1876	Acetylation	QPSQHPEKKNKLVIK CCCCCHHHCCCEEEC	67.12	26051181
1879	Ubiquitination	QHPEKKNKLVIKEKE CCHHHCCCEEECHHH	53.67	-
1927	Phosphorylation	ELAPGGGSEPSMLPP HCCCCCCCCCCCCCH	50.00	-
1930	Phosphorylation	PGGGSEPSMLPPRIA CCCCCCCCCCCHHHC	28.97	-
1938	Phosphorylation	MLPPRIASDARGNAT CCCHHHCCCCCCHHH	29.45	-
1945	Phosphorylation	SDARGNATKALLENF CCCCCHHHHHHHHHH	22.35	-
1993	Phosphorylation	DSCGKLFSNILILKS CCHHHHHHHEEEHHH	33.14	20068231
2013	Ubiquitination	HQNYFPFKQLERFAK HHHCCCHHHHHHHHH	54.96	-
2169	Phosphorylation	QYFDINNSPSEEQIK HHHCCCCCCCHHHHH	25.89	21815630
2171	Phosphorylation	FDINNSPSEEQIKEM HCCCCCCCHHHHHHH	54.29	20068231
2182	Phosphorylation	IKEMADKSGLPQKVI HHHHHHHCCCCHHHH	46.22	-
2207	Phosphorylation	ERQRNKDSPYNFSNP HHHHCCCCCCCCCCC	30.78	30266825
2209	Phosphorylation	QRNKDSPYNFSNPPI HHCCCCCCCCCCCCC	32.56	30266825
2212	Phosphorylation	KDSPYNFSNPPITSL CCCCCCCCCCCCCCH	44.80	30266825
2217	Phosphorylation	NFSNPPITSLEELKI CCCCCCCCCHHHHCC	32.79	30266825
2218	Phosphorylation	FSNPPITSLEELKID CCCCCCCCHHHHCCC	34.21	-
2226	Phosphorylation	LEELKIDSRPPSPEP HHHHCCCCCCCCCCC	50.59	30266825
2230	Phosphorylation	KIDSRPPSPEPPKQE CCCCCCCCCCCCCCC	44.57	30266825
2238	Phosphorylation	PEPPKQEYWGSKRSS CCCCCCCCCCCCCCC	16.75	23186163
2241	Phosphorylation	PKQEYWGSKRSSRTR CCCCCCCCCCCCCCC	15.68	23186163
2349	Sumoylation	DLIKHQKKLCYKDED HHHHHHHHHCCCCCC	36.90	24651376
2437	Phosphorylation	PKLAEAPSAQPNQTQ CCHHCCCCCCCCCCH	46.73	20068231
2443	Phosphorylation	PSAQPNQTQEKQGQP CCCCCCCCHHCCCCC	45.39	20068231
2476	Phosphorylation	QKLPQLVSLPSLPQP HHCCHHCCCCCCCCC	43.06	30177828
2479	Phosphorylation	PQLVSLPSLPQPPPQ CHHCCCCCCCCCCCC	58.96	30177828
2497	Phosphorylation	PQCPLPQSSPSPSQL CCCCCCCCCCCHHHH	42.13	30177828
2498	Phosphorylation	QCPLPQSSPSPSQLS CCCCCCCCCCHHHHC	24.93	30177828
2500	Phosphorylation	PLPQSSPSPSQLSHL CCCCCCCCHHHHCCC	38.85	30177828
2502	Phosphorylation	PQSSPSPSQLSHLPL CCCCCCHHHHCCCCC	48.36	30177828
2505	Phosphorylation	SPSPSQLSHLPLKPL CCCHHHHCCCCCCCC	18.49	30177828
2514	Phosphorylation	LPLKPLHTSTPQQLA CCCCCCCCCCHHHHH	41.81	25627689
2515	Phosphorylation	PLKPLHTSTPQQLAN CCCCCCCCCHHHHHC	27.61	25627689
2516	Phosphorylation	LKPLHTSTPQQLANL CCCCCCCCHHHHHCC	26.69	25627689
2623	Phosphorylation	RKLEEKASASPGEND HHHHHHHHCCCCCCC	40.11	29255136
2625	Phosphorylation	LEEKASASPGENDSG HHHHHHCCCCCCCCC	30.83	29255136
2631	Phosphorylation	ASPGENDSGTGGEEP CCCCCCCCCCCCCCC	50.24	28985074
2633	Phosphorylation	PGENDSGTGGEEPQR CCCCCCCCCCCCCCC	46.06	21712546
2646	Phosphorylation	QRDKRLRTTITPEQL CCCCCCCCCCCHHHH	27.43	21712546
2647	Phosphorylation	RDKRLRTTITPEQLE CCCCCCCCCCHHHHH	19.20	21712546
2649	Phosphorylation	KRLRTTITPEQLEIL CCCCCCCCHHHHHHH	20.76	21712546
2664	Phosphorylation	YQKYLLDSNPTRKML HHHHHCCCCCHHHHH	44.68	21815630
2667	Phosphorylation	YLLDSNPTRKMLDHI HHCCCCCHHHHHHHH	47.36	26270265
2724	Phosphorylation	RALFKAKTALEAHIR HHHHHHHHHHHHHHH	41.14	23403867
2771	Phosphorylation	IFDGTSFSHLPPSSS ECCCCCCCCCCCCCC	24.71	27251275
2776	Phosphorylation	SFSHLPPSSSDGQGV CCCCCCCCCCCCCCC	40.30	30266825
2777	Phosphorylation	FSHLPPSSSDGQGVP CCCCCCCCCCCCCCC	37.92	30266825
2778	Phosphorylation	SHLPPSSSDGQGVPL CCCCCCCCCCCCCCC	50.53	30266825
2786	Phosphorylation	DGQGVPLSPVSKTME CCCCCCCCCCCCCCE	19.72	30266825
2789	Phosphorylation	GVPLSPVSKTMELSP CCCCCCCCCCCEECC	26.28	30266825
2791	Phosphorylation	PLSPVSKTMELSPRT CCCCCCCCCEECCCC	14.36	23403867
2795	Phosphorylation	VSKTMELSPRTLLSP CCCCCEECCCCCCCC	10.07	30266825
2798	Phosphorylation	TMELSPRTLLSPSSI CCEECCCCCCCCCCE	35.12	30266825
2801	Phosphorylation	LSPRTLLSPSSIKVE ECCCCCCCCCCEEEE	26.33	25849741
2803	Phosphorylation	PRTLLSPSSIKVEGI CCCCCCCCCEEEECC	41.12	30266825
2804	Phosphorylation	RTLLSPSSIKVEGIE CCCCCCCCEEEECCC	29.79	30266825
2806	Sumoylation	LLSPSSIKVEGIEDF CCCCCCEEEECCCCC	35.86	24651376
2815	Phosphorylation	EGIEDFESPSMSSVN ECCCCCCCCCCCEEE	23.44	27732954
2817	Phosphorylation	IEDFESPSMSSVNLN CCCCCCCCCCEEECC	40.34	27732954
2819	Phosphorylation	DFESPSMSSVNLNFD CCCCCCCCEEECCCC	35.16	27732954
2820	Phosphorylation	FESPSMSSVNLNFDQ CCCCCCCEEECCCCC	13.34	27732954
2828	Phosphorylation	VNLNFDQTKLDNDDC EECCCCCCCCCCCCC	35.10	27732954
2865	Phosphorylation	ATGIATETKSSSAPN CCCEECCCCCCCCCC	31.69	-
2867	Phosphorylation	GIATETKSSSAPNEG CEECCCCCCCCCCCH	36.62	-
2868	Phosphorylation	IATETKSSSAPNEGL EECCCCCCCCCCCHH	31.88	-
2876	Phosphorylation	SAPNEGLTKAAMMAM CCCCCHHHHHHHHHH	29.51	-
2884	Phosphorylation	KAAMMAMSEYEDRLS HHHHHHHHHHHHHHH	27.73	28348404
2891	Phosphorylation	SEYEDRLSSGLVSPA HHHHHHHHCCCCCCC	24.21	23403867
2892	Phosphorylation	EYEDRLSSGLVSPAP HHHHHHHCCCCCCCC	40.51	23403867
2896	Phosphorylation	RLSSGLVSPAPSFYS HHHCCCCCCCCCCCC	22.01	27362937
2900	Phosphorylation	GLVSPAPSFYSKEYD CCCCCCCCCCCCCCC	38.63	27362937
2902	Phosphorylation	VSPAPSFYSKEYDNE CCCCCCCCCCCCCCC	24.14	23403867
2903	Phosphorylation	SPAPSFYSKEYDNEG CCCCCCCCCCCCCCC	19.59	23403867
2925	Phosphorylation	SSLADPCSPSPGASG CCCCCCCCCCCCCCC	33.53	28985074
2951	Phosphorylation	PGQKRFRTQMTNLQL CCCHHHHHHHHHHHH	21.71	28509920
2954	Phosphorylation	KRFRTQMTNLQLKVL HHHHHHHHHHHHHHH	23.98	19413330
3007	Phosphorylation	KEKKSKLSMAKHFGI HHHHHHHHHHHHHCC	22.04	-
3017	Phosphorylation	KHFGINQTSYEGPKT HHHCCCCCCCCCCCC	28.87	21712546
3018	Phosphorylation	HFGINQTSYEGPKTE HHCCCCCCCCCCCCE	16.07	25159151
3053	Ubiquitination	QQHISKVKDTIGSQL HHHHHHHHHHHHCHH	53.54	-
3064	Ubiquitination	GSQLDKEKEYFDPAT HCHHHHHHHHCCHHH	64.55	-
3066	Phosphorylation	QLDKEKEYFDPATVR HHHHHHHHCCHHHHH	25.09	27642862
3258	Sumoylation	GEPLPVPKKEKGEAP CCCCCCCCCCCCCCC	74.02	24651376
3399	Phosphorylation	QQQQPKASQTPVPPG HHHCCCHHCCCCCCC	40.49	30266825
3401	Phosphorylation	QQPKASQTPVPPGAP HCCCHHCCCCCCCCC	24.61	30266825
3409	Phosphorylation	PVPPGAPSPDKDPAK CCCCCCCCCCCCCCC	45.24	30266825
3416	Acetylation	SPDKDPAKESPKPEE CCCCCCCCCCCCHHH	65.20	7675329
3418	Phosphorylation	DKDPAKESPKPEEQK CCCCCCCCCCHHHHC	37.20	27362937
3420	Acetylation	DPAKESPKPEEQKNT CCCCCCCCHHHHCCC	74.47	7675339
3432	Phosphorylation	KNTPREVSPLLPKLP CCCCCCCCCCCCCCC	12.70	29255136
3446	Phosphorylation	PEEPEAESKSADSLY CCCCCHHCCCCCCCC	38.67	23403867
3447	Ubiquitination	EEPEAESKSADSLYD CCCCHHCCCCCCCCC	40.96	-
3448	Phosphorylation	EPEAESKSADSLYDP CCCHHCCCCCCCCCC	46.73	22199227
3451	Phosphorylation	AESKSADSLYDPFIV HHCCCCCCCCCCCCC	28.66	27732954
3453	Phosphorylation	SKSADSLYDPFIVPK CCCCCCCCCCCCCCH	26.06	27732954
3460	Ubiquitination	YDPFIVPKVQYKLVC CCCCCCCHHHHHHHH	30.95	-
3570	Phosphorylation	RNAKEHPSLLPHSAC HHHHHCCCCCCCCCC	44.43	23663014
3575	Phosphorylation	HPSLLPHSACFPDPS CCCCCCCCCCCCCCC	25.45	23663014
3582	Phosphorylation	SACFPDPSTASTSQS CCCCCCCCCCCCCHH	43.94	23663014
3583	Phosphorylation	ACFPDPSTASTSQSA CCCCCCCCCCCCHHH	29.98	23663014
3585	Phosphorylation	FPDPSTASTSQSAAH CCCCCCCCCCHHHHC	28.78	23663014
3586	Phosphorylation	PDPSTASTSQSAAHS CCCCCCCCCHHHHCC	28.46	23663014
3587	Phosphorylation	DPSTASTSQSAAHSN CCCCCCCCHHHHCCC	21.46	23663014
3589	Phosphorylation	STASTSQSAAHSNDS CCCCCCHHHHCCCCC	27.47	23663014
3593	Phosphorylation	TSQSAAHSNDSPPPP CCHHHHCCCCCCCCC	37.29	23663014
3596	Phosphorylation	SAAHSNDSPPPPSAA HHHCCCCCCCCCCCC	43.48	23663014
3601	Phosphorylation	NDSPPPPSAAAPSSA CCCCCCCCCCCCCCC	35.99	23663014
3606	Phosphorylation	PPSAAAPSSASPHAS CCCCCCCCCCCCCCC	33.53	23663014
3607	Phosphorylation	PSAAAPSSASPHASR CCCCCCCCCCCCCCC	31.54	23663014
3609	Phosphorylation	AAAPSSASPHASRKS CCCCCCCCCCCCCCC	21.11	23663014
3613	Phosphorylation	SSASPHASRKSWPQV CCCCCCCCCCCHHHH	36.89	23663014
3616	Phosphorylation	SPHASRKSWPQVVSR CCCCCCCCHHHHHHH	42.76	28555341
3672	Phosphorylation	DTDLSQKSDGPASPV CCCHHHCCCCCCCCC	39.91	20363803
3677	O-linked_Glycosylation	QKSDGPASPVEGPKD HCCCCCCCCCCCCCC	32.39	30059200
3677	Phosphorylation	QKSDGPASPVEGPKD HCCCCCCCCCCCCCC	32.39	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM25	Q14258	PMID:22452784

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZFHX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZFHX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NINL_HUMAN	NINL	physical	16189514
TRI25_HUMAN	TRIM25	physical	22452784
PIAS3_HUMAN	PIAS3	physical	14715251
STAT3_HUMAN	STAT3	physical	14715251
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZFHX3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1197 AND SER-1204, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.	18088087 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1180, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, AND MASSSPECTROMETRY.	17081983 [Abstract]