RKM2_YEAST - dbPTM
RKM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RKM2_YEAST
UniProt AC Q03942
Protein Name Ribosomal lysine N-methyltransferase 2 {ECO:0000303|PubMed:17005568}
Gene Name RKM2 {ECO:0000303|PubMed:17005568}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 479
Subcellular Localization
Protein Description S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at 'Lys-4' and 'Lys-11'..
Protein Sequence MEGKVDVLLTWLKKSDKFYIAPNISICESPETGRGIVLSHGSIRKNDIIVSVPSSKQLNFHTILYHISKFNKELNIPGITIDRKPINYEDNIIEAENKAWADPRYGLYSELSKEFLLSLSSFQLVSFYILVENFLLPKWTHNEIYSDWKPFFDVWPSMEELRSIPAIWNCDPNSRYHSLIEYLPAASRKHMARISGLVREDWETISEVVLKWNEIYGSLSCTKNSDKFTSDELFSLFVHVYFIINSRCLYAKIPLKIEDSPSNFTLVPYVDFMNHICESDLHCYPQLSPQLRSEGENIIGIGQFTIRCGDHLYDNINEELFLNYGAHSNDFLLNEYGFVVDGNKWNYLDISDEIIELIDDDKKEVKTFLLEHDYWGDYTINETDISYRIFVALNYYVTRDERRVRKFIEGYISEDYFKPKISSVLKELLVSLTAKYTKTLSELTEKVSNLENNLCLQNLITIYKGYIKILTQHLQDLQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
195PhosphorylationRKHMARISGLVREDW
HHHHHHHHHHHHCCH		22.1128889911
235PhosphorylationFTSDELFSLFVHVYF
CCHHHHHHHHHHHHH		33.2625521595
241PhosphorylationFSLFVHVYFIINSRC
HHHHHHHHHHHCCCE		3.6825521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RKM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RKM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RKM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CWC15_YEASTCWC15genetic
19061648
POP7_YEASTPOP7genetic
19061648
SWD3_YEASTSWD3genetic
19061648
RPB4_YEASTRPB4genetic
19061648
PFD5_YEASTGIM5genetic
19061648
SAP30_YEASTSAP30genetic
19061648
NU170_YEASTNUP170genetic
19061648
EAF5_YEASTEAF5genetic
19061648
SWD3_YEASTSWD3genetic
19547744
PFD5_YEASTGIM5genetic
19547744
CSG2_YEASTCSG2genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
IME2_YEASTIME2genetic
27708008
AIM34_YEASTAIM34genetic
27708008
SIW14_YEASTSIW14genetic
27708008
AGA1_YEASTAGA1genetic
27708008
INO4_YEASTINO4genetic
27708008
ASE1_YEASTASE1genetic
27708008
VPS21_YEASTVPS21genetic
27708008
SFL1_YEASTSFL1genetic
27708008
PDR5_YEASTPDR5genetic
27708008
KIN4_YEASTKIN4genetic
27708008
YDC1_YEASTYDC1genetic
27708008
DBP1_YEASTDBP1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
ASNS1_YEASTASN1genetic
27708008
ATG13_YEASTATG13genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RKM2_YEAST

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Related Literatures of Post-Translational Modification

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