dbPTM

CWC15_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CWC15_YEAST
UniProt AC	Q03772
Protein Name	Pre-mRNA-splicing factor CWC15
Gene Name	CWC15
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	175
Subcellular Localization	Nucleus .
Protein Description	Involved in pre-mRNA splicing..
Protein Sequence	MTTSHRPQLEARSGAKAAAYTPTGIEHARLLPGHTTLKYRKFKEEENLRANCAQEDRSNDKSLEEAVMNEEKQDVVGSGNLQETRSEKDQKDSLQELLVTQKNKVEDKAELEGNEQLKGGNSSRRSWRKGTAFGRHKVTKETNIKEHATKKSASGYINDMTKSEYHQEFLHKHVR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GAKAAAYTPTGIEHA CCCCCCCCCCCHHHH	15.06	28132839
41	Acetylation	HTTLKYRKFKEEENL CCCCCCCCCHHHHCH	58.67	25381059
62	Phosphorylation	EDRSNDKSLEEAVMN CHHCCCHHHHHHHHC	43.83	28889911
88	Acetylation	LQETRSEKDQKDSLQ HHHHCCHHHHHHHHH	67.70	24489116
104	Acetylation	LLVTQKNKVEDKAEL HHHHHHCHHCCHHHH	54.78	24489116
108	Acetylation	QKNKVEDKAELEGNE HHCHHCCHHHHCCCC	30.19	24489116
152	Phosphorylation	KEHATKKSASGYIND HHHHCHHHHCCCCCC	29.26	24961812
154	Phosphorylation	HATKKSASGYINDMT HHCHHHHCCCCCCCC	38.94	24961812
156	Phosphorylation	TKKSASGYINDMTKS CHHHHCCCCCCCCHH	8.28	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CWC15_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CWC15_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CWC15_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP19_YEAST	PRP19	genetic	19061648
STP1_YEAST	STP1	genetic	19061648
CWC21_YEAST	CWC21	genetic	19061648
ELP2_YEAST	ELP2	genetic	19061648
ISY1_YEAST	ISY1	genetic	19061648
RU2A_YEAST	LEA1	genetic	19061648
NCBP2_YEAST	CBC2	genetic	19061648
TGS1_YEAST	TGS1	genetic	19061648
BRR1_YEAST	BRR1	genetic	19061648
YPT6_YEAST	YPT6	genetic	19061648
APC11_YEAST	APC11	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
PSB7_YEAST	PRE4	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
NOP56_YEAST	NOP56	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
TAF5_YEAST	TAF5	genetic	27708008
TECR_YEAST	TSC13	genetic	27708008
PRP11_YEAST	PRP11	genetic	27708008
RPN5_YEAST	RPN5	genetic	27708008
SYF1_YEAST	SYF1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
RNA15_YEAST	RNA15	genetic	27708008
PRP18_YEAST	PRP18	genetic	27708008
COAD_YEAST	CAB4	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
KRE9_YEAST	KRE9	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
CWC16_YEAST	YJU2	genetic	27708008
CLF1_YEAST	CLF1	genetic	27708008
IMB1_YEAST	KAP95	genetic	27708008
TAF4_YEAST	TAF4	genetic	27708008
MED11_YEAST	MED11	genetic	27708008
CEF1_YEAST	CEF1	genetic	27708008
SPC98_YEAST	SPC98	genetic	27708008
SMP3_YEAST	SMP3	genetic	27708008
MED4_YEAST	MED4	genetic	27708008
TOA1_YEAST	TOA1	genetic	27708008
DYR_YEAST	DFR1	genetic	27708008
TIM50_YEAST	TIM50	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
ARP7_YEAST	ARP7	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
WHI4_YEAST	WHI4	genetic	27708008
CWC21_YEAST	CWC21	genetic	27708008
BUD27_YEAST	BUD27	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
ICE2_YEAST	ICE2	genetic	27708008
ISY1_YEAST	ISY1	genetic	27708008
MUD2_YEAST	MUD2	genetic	27708008
KTI12_YEAST	KTI12	genetic	27708008
GBLP_YEAST	ASC1	genetic	27708008
SIW14_YEAST	SIW14	genetic	27708008
MAS5_YEAST	YDJ1	genetic	27708008
KC12_YEAST	YCK2	genetic	27708008
PHO80_YEAST	PHO80	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
AIM44_YEAST	AIM44	genetic	27708008
RU2A_YEAST	LEA1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CWC15_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, AND MASSSPECTROMETRY.	18407956 [Abstract]