PUS1_YEAST - dbPTM
PUS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUS1_YEAST
UniProt AC Q12211
Protein Name tRNA pseudouridine synthase 1
Gene Name PUS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 544
Subcellular Localization Nucleus .
Protein Description Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). [PubMed: 9671058]
Protein Sequence MSEENLRPAYDDQVNEDVYKRGAQSKLTKARKADFDDEKDKKKDNDKHIDKRPKSGPRLDENGNPLPKEPRLPKRKVAVMVGYCGTGYHGMQYNPPNPTIESALFKAFVEAGAISKDNSNDLKKNGFMRAARTDKGVHAGGNLISLKMIIEDPDIKQKINEKLPEGIRVWDIERVNKAFDCRKMCSSRWYEYLLPTYSLIGPKPGSILYRDIEESKTELPGVLDEDLESKEFWEEFKKDANEKFSTEEIEAILAYVPPARDEFDINEELYQKVKKYKQLENAHRRRYRISAAKLAKFRASTSQYLGAHNFHNFTLGKDFKEPSAIRFMKDIKVSDPFVIGDAQTEWISIKIHGQSFMLHQIRKMVSMATLITRCGCPVERISQAYGQQKINIPKAPALGLLLEAPVFEGYNKRLEQFGYKAIDFSKYQDEVDKFKMKHIYDKIYKEEVDENVFNAFFSYIDSFNKVTGAQGEETADKSGPAVQKSIFEFLTAKGIPGLTDAPESNKKIKQRKRMEEEEAASKKAEISSTTQSNEPEVQPEAAAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEENLRPA
------CCHHHCCCC		54.3322369663
10PhosphorylationEENLRPAYDDQVNED
HHHCCCCCCHHCCHH		23.8030377154
20AcetylationQVNEDVYKRGAQSKL
HCCHHHHHHHHHHHH		44.1724489116
26AcetylationYKRGAQSKLTKARKA
HHHHHHHHHHHHHHC		48.3624489116
116AcetylationVEAGAISKDNSNDLK
HHHCCCCCCCCCHHH		55.6124489116
156AcetylationIIEDPDIKQKINEKL
EECCCCHHHHHHHHC		53.5824489116
156UbiquitinationIIEDPDIKQKINEKL
EECCCCHHHHHHHHC		53.5823749301
158UbiquitinationEDPDIKQKINEKLPE
CCCCHHHHHHHHCCC		42.3622817900
177AcetylationWDIERVNKAFDCRKM
EEHHHHHHHHHHHHH		47.8025381059
366PhosphorylationHQIRKMVSMATLITR
HHHHHHHHHHHHHHH		10.1322369663
369PhosphorylationRKMVSMATLITRCGC
HHHHHHHHHHHHCCC		15.2822369663
372PhosphorylationVSMATLITRCGCPVE
HHHHHHHHHCCCCHH		24.0322369663
394UbiquitinationQQKINIPKAPALGLL
CCCCCCCCCCHHHHH		64.3023749301
420AcetylationRLEQFGYKAIDFSKY
HHHHHCCCCCCHHHC		38.9624489116
426AcetylationYKAIDFSKYQDEVDK
CCCCCHHHCHHHHHH		47.1024489116
442AcetylationKMKHIYDKIYKEEVD
HHHHHHHHHHHHHCC		30.8522865919
477UbiquitinationQGEETADKSGPAVQK
CCCCCCCCCCHHHHH		55.6523749301
478PhosphorylationGEETADKSGPAVQKS
CCCCCCCCCHHHHHH		51.0230377154
504PhosphorylationGLTDAPESNKKIKQR
CCCCCCHHHHHHHHH		53.5423749301
521PhosphorylationMEEEEAASKKAEISS
HHHHHHHHHHHHHHC		41.5623749301
522AcetylationEEEEAASKKAEISST
HHHHHHHHHHHHHCC		51.8025381059
527PhosphorylationASKKAEISSTTQSNE
HHHHHHHHCCCCCCC		17.0921551504
528PhosphorylationSKKAEISSTTQSNEP
HHHHHHHCCCCCCCC		40.9327017623
529PhosphorylationKKAEISSTTQSNEPE
HHHHHHCCCCCCCCC		23.2830377154
530PhosphorylationKAEISSTTQSNEPEV
HHHHHCCCCCCCCCC		31.7619779198
532PhosphorylationEISSTTQSNEPEVQP
HHHCCCCCCCCCCCH		40.8619779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUS1_YEASTPUS1physical
14759368
UTP22_YEASTUTP22physical
11805826
XPOT_YEASTLOS1genetic
8641292
XPOT_YEASTLOS1genetic
18314501
ARC1_YEASTARC1genetic
19061648
XPOT_YEASTLOS1genetic
19061648
PAP2_YEASTPAP2genetic
19061648
TRM10_YEASTTRM10genetic
19061648
LSM7_YEASTLSM7genetic
19061648
MEX67_YEASTMEX67genetic
19061648
SYNC_YEASTDED81genetic
19061648
POP8_YEASTPOP8genetic
19061648
HIR2_YEASTHIR2genetic
19061648
IF2G_YEASTGCD11genetic
19061648
SSB2_YEASTSSB2physical
19536198
SSB1_YEASTSSB1physical
19536198
PUS2_YEASTPUS2genetic
18408719
STE50_YEASTSTE50genetic
27708008
SRF1_YEASTSRF1genetic
27708008
TRMB_YEASTTRM8genetic
27708008
MAF1_YEASTMAF1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
TRM82_YEASTTRM82genetic
27708008
GCN1_YEASTGCN1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
FRA1_YEASTFRA1genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
DUS3_YEASTDUS3genetic
27708008
TRM10_YEASTTRM10genetic
27708008
PUS1_YEASTPUS1genetic
26873591
COPB2_HUMANCOPB2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUS1_YEAST

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Related Literatures of Post-Translational Modification

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