TRMB_YEAST - dbPTM
TRMB_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRMB_YEAST
UniProt AC Q12009
Protein Name tRNA (guanine-N(7)-)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}
Gene Name TRM8 {ECO:0000255|HAMAP-Rule:MF_03055}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 286
Subcellular Localization Nucleus .
Protein Description Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity..
Protein Sequence MKAKPLSQDPGSKRYAYRINKEENRKELKHVKINESSLVQEGQKIDLPKKRYYRQRAHSNPFSDHQLEYPVSPQDMDWSKLYPYYKNAENGQMTKKVTIADIGCGFGGLMIDLSPAFPEDLILGMEIRVQVTNYVEDRIIALRNNTASKHGFQNINVLRGNAMKFLPNFFEKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLKEGGVVYTITDVKDLHEWMVKHLEEHPLFERLSKEWEENDECVKIMRNATEEGKKVERKKGDKFVACFTRLPTPAIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MKAKPLSQDPGSKR
-CCCCCCCCCCCCHH		40.8519823750
12PhosphorylationPLSQDPGSKRYAYRI
CCCCCCCCHHHEEEC		21.2419823750
13AcetylationLSQDPGSKRYAYRIN
CCCCCCCHHHEEECC		56.1725381059
21AcetylationRYAYRINKEENRKEL
HHEEECCCHHHHHHH		65.1225381059
32AcetylationRKELKHVKINESSLV
HHHHCCCEECHHHHH		39.2622865919
36PhosphorylationKHVKINESSLVQEGQ
CCCEECHHHHHCCCC		25.2022369663
37PhosphorylationHVKINESSLVQEGQK
CCEECHHHHHCCCCC		26.7822369663
59PhosphorylationYYRQRAHSNPFSDHQ
HHHHCCCCCCCCCCC		45.2517330950
63PhosphorylationRAHSNPFSDHQLEYP
CCCCCCCCCCCCCCC		35.1321551504
69PhosphorylationFSDHQLEYPVSPQDM
CCCCCCCCCCCHHHC		19.9521551504
72PhosphorylationHQLEYPVSPQDMDWS
CCCCCCCCHHHCCHH		16.6124961812
79PhosphorylationSPQDMDWSKLYPYYK
CHHHCCHHHHCCCCC		14.4424961812
149AcetylationLRNNTASKHGFQNIN
EECCCHHHCCCCCCC		45.3322865919
164AcetylationVLRGNAMKFLPNFFE
EECCCHHHHCCCHHH		41.1424489116
172AcetylationFLPNFFEKGQLSKMF
HCCCHHHHCCCHHHE		46.9624489116
230AcetylationDLHEWMVKHLEEHPL
HHHHHHHHHHHHCCH		26.7724489116
282PhosphorylationACFTRLPTPAIL---
EEEECCCCCCCC---		29.9121551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
7SPhosphorylationKinaseATMP38110
Uniprot
7SPhosphorylationKinaseATRP38111
Uniprot
7SPhosphorylationKinaseATM/ATR-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRMB_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRMB_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRM82_YEASTTRM82physical
12403464
TRM82_YEASTTRM82physical
16554755
YRA1_YEASTYRA1physical
16554755
DUS1_YEASTDUS1genetic
16387656
DUS2_YEASTSMM1genetic
16387656
PAP2_YEASTPAP2genetic
16387656
RRP6_YEASTRRP6genetic
16387656
TRM82_YEASTTRM82physical
18184583
TRM82_YEASTTRM82physical
18029735
TRM82_YEASTTRM82physical
18164779
MOD5_YEASTMOD5genetic
18314501
PUS1_YEASTPUS1genetic
18314501
XPOT_YEASTLOS1genetic
18314501
TRM10_YEASTTRM10genetic
18314501
MET22_YEASTMET22genetic
18443146
XRN2_YEASTRAT1genetic
18443146
XRN1_YEASTXRN1genetic
18443146
PAP2_YEASTPAP2genetic
18443146
RRP6_YEASTRRP6genetic
18443146
RIC1_YEASTRIC1genetic
19061648
NCL1_YEASTNCL1genetic
19061648
POP8_YEASTPOP8genetic
19061648
PUS7_YEASTPUS7genetic
19061648
PUS1_YEASTPUS1genetic
19061648
UTP9_YEASTUTP9genetic
19061648
PES4_YEASTPES4genetic
19061648
EFM7_YEASTNNT1genetic
19061648
LHP1_YEASTLHP1genetic
19061648
TRM7_YEASTTRM7genetic
19061648
MRT4_YEASTMRT4genetic
19061648
UAF30_YEASTUAF30genetic
19061648
USA1_YEASTUSA1genetic
19061648
MRD1_YEASTMRD1genetic
19061648
TRM82_YEASTTRM82physical
20826334
DUS4_YEASTDUS4genetic
16387656
TRM10_YEASTTRM10genetic
16387656
NCL1_YEASTNCL1genetic
16387656
PUS7_YEASTPUS7genetic
16387656
DUS3_YEASTDUS3genetic
16387656
NCL1_YEASTNCL1genetic
22895820
EF1A_YEASTTEF2genetic
22895820
MET22_YEASTMET22genetic
22895820
NCL1_YEASTNCL1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
MCFS2_YEASTEHT1genetic
27708008
UBP3_YEASTUBP3genetic
27708008
PUS1_YEASTPUS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRMB_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-37, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.

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