| UniProt ID | DUS1_YEAST | |
|---|---|---|
| UniProt AC | P53759 | |
| Protein Name | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)] | |
| Gene Name | DUS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 423 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs.. | |
| Protein Sequence | MTEPALSSANNALMQKLTGRQLFDKIGRPTRIVAPMVDQSELAWRILSRRYGATLAYTPMLHAKLFATSKKYREDNWSSLDGSSVDRPLVVQFCANDPEYLLAAAKLVEDKCDAVDLNLGCPQGIAKKGHYGSFLMEEWDLIHNLINTLHKNLKVPVTAKIRIFDDCEKSLNYAKMVLDAGAQFLTVHGRVREQKGQKTGLANWETIKYLRDNLPKETVFFANGNILYPEDISRCMEHIGADAVMSAEGNLYNPGVFNVGQTKNKEKIFPRVDKIIREYFQIVKECQESKASKTAMKSHFFKILRPFLPHHTDIRSTLATMNAKATWEEWEEQVVKPVEKVVQEIFEQPDIAIKDEITIGEKQSWGGSYRTVPYWRCQPYFRPVNGITGDKRVMQGLIDESVNKKRKADVPLESADKKKDVKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MTEPALSSA ------CCHHHHHHH | 51.15 | 22814378 | |
| 7 | Phosphorylation | -MTEPALSSANNALM -CCHHHHHHHHHHHH | 29.52 | 30377154 | |
| 8 | Phosphorylation | MTEPALSSANNALMQ CCHHHHHHHHHHHHH | 35.55 | 19779198 | |
| 18 | Phosphorylation | NALMQKLTGRQLFDK HHHHHHHHHHHHHHH | 37.04 | 19779198 | |
| 25 | Acetylation | TGRQLFDKIGRPTRI HHHHHHHHHCCCEEE | 39.46 | 24489116 | |
| 169 | Ubiquitination | RIFDDCEKSLNYAKM EEECCHHHHCCHHHH | 67.58 | 23749301 | |
| 391 | Acetylation | VNGITGDKRVMQGLI CCCCCCCHHHHHHHC | 48.51 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DUS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DUS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DUS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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