DUS4_YEAST - dbPTM
DUS4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DUS4_YEAST
UniProt AC Q06063
Protein Name tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]
Gene Name DUS4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 367
Subcellular Localization
Protein Description Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20a and U20b in cytoplasmic tRNAs..
Protein Sequence MHTMHIPSGDVLIPKPKLITEETDPLHIIKTRQKTHGRPVTIAGPMVRYSKLPFRQLCREYNVDIVYSPMILAREYVRNEHARISDLSTNNEDTPLIVQVGVNNVADLLKFVEMVAPYCDGIGINCGCPIKEQIREGIGCALIYNSDLLCSMVHAVKDKYGDKLRIETKIRIHEALDETVELCRKLCDAGVDWITIHGRTRRTRSSQPANLDAIKYIIENISDKNVPVIANGDCFKLSDLERITKYTGAHGVMAVRGLLSNPALFAGYTTCPWGCIEKFCYWALEFGGLPFQLAQHHLYCMLENMELKKSLLKKMMNLKNYISLIDWFNKTFEFKRYGEDGFGMGVEIPYKANSCVQRSASVVERQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MHTMHIPSGD
-----CCCCCCCCCC		14.7830377154
30AcetylationTDPLHIIKTRQKTHG
CCCCEEEECCCCCCC		36.7324489116
195PhosphorylationDAGVDWITIHGRTRR
HCCCCEEEEECCCCC		11.5823749301
321PhosphorylationKMMNLKNYISLIDWF
HHHCHHHHHHHHHHH		7.1219823750
323PhosphorylationMNLKNYISLIDWFNK
HCHHHHHHHHHHHHC		14.6519795423
354PhosphorylationEIPYKANSCVQRSAS
EECCCCCCCHHHCCC		22.1121440633
359PhosphorylationANSCVQRSASVVERQ
CCCCHHHCCCHHCCC		14.0622890988
361PhosphorylationSCVQRSASVVERQE-
CCHHHCCCHHCCCC-		28.1319823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DUS4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DUS4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DUS4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STP3_YEASTSTP3genetic
19061648
SAP30_YEASTSAP30genetic
19061648
SRS2_YEASTSRS2genetic
21459050
CKS1_YEASTCKS1genetic
27708008
MED8_YEASTMED8genetic
27708008
RRP1_YEASTRRP1genetic
27708008
SHG1_YEASTSHG1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
SDC1_YEASTSDC1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MAL12_YEASTMAL12genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
FEN1_YEASTRAD27genetic
27708008
NNK1_YEASTNNK1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
POM33_YEASTPOM33genetic
27708008
RAD14_YEASTRAD14genetic
27708008
ODP2_YEASTLAT1genetic
27708008
HAP5_YEASTHAP5genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DUS4_YEAST

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Related Literatures of Post-Translational Modification

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