| UniProt ID | XPOT_YEAST | |
|---|---|---|
| UniProt AC | P33418 | |
| Protein Name | Exportin-T | |
| Gene Name | LOS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1100 | |
| Subcellular Localization | Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm and the localization is regulated by SNF1 kinase, nutrient supply and stress. | |
| Protein Description | tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.. | |
| Protein Sequence | MLERIQQLVNAVNDPRSDVATKRQAIELLNGIKSSENALEIFISLVINENSNDLLKFYGLSTLIELMTEGVNANPNGLNLVKFEITKWLKFQVLGNKQTKLPDFLMNKISEVLTTLFMLMYSDCNGNQWNSFFDDLMSLFQVDSAISNTSPSTDGNILLGLEFFNKLCLMINSEIADQSFIRSKESQLKNNNIKDWMRDNDIMKLSNVWFQCLKLDEQIVSQCPGLINSTLDCIGSFISWIDINLIIDANNYYLQLIYKFLNLKETKISCYNCILAIISKKMKPMDKLAFLNMINLTNELTYYHQAISMNPQIITFDNLEVWESLTKLITSFGIEFTIIIEQVNDDQKLDTLYKQSVISNVDSILLEKIIPILLEFMNNEFDSITAKTFPFWSNYLAFLKKYKASSPNFVPLHKDFLDNFQQICFKRMKFSDDEVTQDDFEEFNETVRFKLKNFQEIIVVIDPSLFLNNISQEISANLMNCKNESWQIFELTIYQIFNLSECTKNNYFGLNKNEIMTSQPSLTLVRFLNELLMMKDFLLAIDNEQIQILFMELIVKNYNFIFSTSANTANATDDDEKYLLILNIFMSSFAMFNKRENVRLRSWYLFTRFLKLTRINLKKILFANKNLVNEITNKISPLLHIKVTSINAQGTDDNDTIFDNQLYIFEGIGFIITLNNSSQELTAATANTPIDYDILDQILTPLFTQLEGCITQGASPVVILECHHILMAIGTLARGLHIGLVPENQVNNMVVNKKLINDSLIHKFSNIAEVILVTFSFFNKFENIRDASRFTFARLIPILSNKILPFINKLIELILSSTDLKSWEMIDFLGFLSQLIHMFHTDTDCYQLFNQLLTPLINKVHSIIEEIDEQHDQQSSSNKPIDTAVTATSVNKNIVVTDSYRDKILLKKAYCTFLQSFTNNSVTSILLSDINRAILPVILNDLVTYTPQEIQETSMMKVSLNVLCNFIKCFGNGTCLDNDDINKDPNLKIDGLNEYFIMKCVPIIFEIPFNPIYKFNIKEGNFKTMAYDLARLLRELFIVSSNPTTNENECVKYLTQIYLPQIQLPQELTIQLVNMLTTMGQKQFEKWFVDNFISVLKQGQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 279 | Phosphorylation | NCILAIISKKMKPMD HHHHHHHHHCCCCCC | 21.80 | 23749301 | |
| 280 | Ubiquitination | CILAIISKKMKPMDK HHHHHHHHCCCCCCH | 46.61 | 23749301 | |
| 356 | Phosphorylation | LDTLYKQSVISNVDS HHHHHHHHHHHCHHH | 19.78 | 29136822 | |
| 359 | Phosphorylation | LYKQSVISNVDSILL HHHHHHHHCHHHHHH | 28.75 | 29136822 | |
| 363 | Phosphorylation | SVISNVDSILLEKII HHHHCHHHHHHHHHH | 15.74 | 29136822 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XPOT_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XPOT_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XPOT_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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