| UniProt ID | TAF3_YEAST | |
|---|---|---|
| UniProt AC | Q12297 | |
| Protein Name | Transcription initiation factor TFIID subunit 3 | |
| Gene Name | TAF3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 353 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.. | |
| Protein Sequence | MTTNNDFYFALLRISILQLLKAQGFDRARPSLVDVMTDLYAKFLSLLASEVSSIAQARCDQDDTIALQDITLALENLGIVKPTNVLDVYDENSELSSSRGMEKFKDWCIYSTQLTDARITALPTVELLQSEEKESDPLSAIPDYLNQLLQNKGAKQKLETKNRKTELIEDLINNNGLDDWIKLVIARQRINMIERASKKESQNVPALPHIAGYKSSILSRHHHTTITNEDRMPSAMTPRDEDALTEIQENPFVTSKLPIMRKENRLENITLSFEDEELESLGEVEGPNQKSQENNNEESFKENNKSLTESPHGDDRDISMFQFDSNVDTKWAEQEDMDSTFQRRTSLDYGGYF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 214 | Acetylation | LPHIAGYKSSILSRH CCCCCCCHHCHHHHC | 36.49 | 24489116 | |
| 215 | Phosphorylation | PHIAGYKSSILSRHH CCCCCCHHCHHHHCC | 17.71 | 19795423 | |
| 216 | Phosphorylation | HIAGYKSSILSRHHH CCCCCHHCHHHHCCC | 24.32 | 19795423 | |
| 219 | Phosphorylation | GYKSSILSRHHHTTI CCHHCHHHHCCCCCC | 28.09 | 19795423 | |
| 237 | Phosphorylation | DRMPSAMTPRDEDAL CCCCCCCCCCCHHHH | 18.19 | 28889911 | |
| 280 | Phosphorylation | FEDEELESLGEVEGP ECHHHHHHHCCCCCC | 55.06 | 20377248 | |
| 291 | Phosphorylation | VEGPNQKSQENNNEE CCCCCHHCCCCCCHH | 32.72 | 28889911 | |
| 299 | Phosphorylation | QENNNEESFKENNKS CCCCCHHHHHHHHHC | 35.13 | 23749301 | |
| 306 | Phosphorylation | SFKENNKSLTESPHG HHHHHHHCCCCCCCC | 42.52 | 24961812 | |
| 308 | Phosphorylation | KENNKSLTESPHGDD HHHHHCCCCCCCCCC | 41.32 | 20377248 | |
| 310 | Phosphorylation | NNKSLTESPHGDDRD HHHCCCCCCCCCCCC | 19.57 | 17330950 | |
| 319 | Phosphorylation | HGDDRDISMFQFDSN CCCCCCCCEEEECCC | 20.17 | 28889911 | |
| 345 | Phosphorylation | DSTFQRRTSLDYGGY CHHHHHHHCCCCCCC | 35.51 | 22890988 | |
| 346 | Phosphorylation | STFQRRTSLDYGGYF HHHHHHHCCCCCCCC | 19.89 | 22369663 | |
| 349 | Phosphorylation | QRRTSLDYGGYF--- HHHHCCCCCCCC--- | 20.11 | 22890988 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAF3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAF3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237; SER-310 ANDSER-346, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND MASSSPECTROMETRY. | |
