RFM1_YEAST - dbPTM
RFM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RFM1_YEAST
UniProt AC Q12192
Protein Name Repression factor of MSEs protein 1
Gene Name RFM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 310
Subcellular Localization Nucleus.
Protein Description Tethering factor required for histone deacetylase HST1-mediated repression. Probably involved in targeting HST1 to a subset of SUM1-regulated genes..
Protein Sequence MSTNTEIIKNSDLQSLINDKRRLINEIKDFNKSIKPLEFESYQDYFLIKTFKKGISASGHVDIDSLRNKEYGIYYKKIKRNSTQEVGEPIPRNTSSSSSSTRSNSSADISDTEYSGENTPTTTGAASRRRRTRSRAIQRENSLPASLPSISEANANNDDVTISEINGSELPFPIPISEVENIDIASDITERDGIRRRSSRISERDKRRSQSRLGSEEDEEGDGHDGDEGETKIQDLYESLVPKILESRRRSDWILPPKARYTPEKQMRTKPSFKSIKINELVGNKRIRSILSRFEGGVAGIRKRDWDSTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
82PhosphorylationYKKIKRNSTQEVGEP
EEECCCCCCCCCCCC		35.1923749301
83PhosphorylationKKIKRNSTQEVGEPI
EECCCCCCCCCCCCC		32.0930377154
103PhosphorylationSSSSSTRSNSSADIS
CCCCCCCCCCCCCCC		40.9528132839
105PhosphorylationSSSTRSNSSADISDT
CCCCCCCCCCCCCCC		28.3119779198
106PhosphorylationSSTRSNSSADISDTE
CCCCCCCCCCCCCCC		33.9223749301
110PhosphorylationSNSSADISDTEYSGE
CCCCCCCCCCCCCCC		38.7428152593
112PhosphorylationSSADISDTEYSGENT
CCCCCCCCCCCCCCC		29.9928152593
114PhosphorylationADISDTEYSGENTPT
CCCCCCCCCCCCCCC		24.8627738172
119PhosphorylationTEYSGENTPTTTGAA
CCCCCCCCCCCCCHH		20.0823749301
186PhosphorylationVENIDIASDITERDG
EECEECCCCCCHHHC		29.8527214570
209PhosphorylationSERDKRRSQSRLGSE
CHHHHHHHHHHCCCC		36.2221551504
211PhosphorylationRDKRRSQSRLGSEED
HHHHHHHHHCCCCCC		30.6223749301
215PhosphorylationRSQSRLGSEEDEEGD
HHHHHCCCCCCCCCC		42.2619823750
231PhosphorylationHDGDEGETKIQDLYE
CCCCCCCHHHHHHHH		44.2819823750
274AcetylationMRTKPSFKSIKINEL
HCCCCCCCCCCHHHH		56.4625381059
285AcetylationINELVGNKRIRSILS
HHHHHCCHHHHHHHH		43.1825381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RFM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RFM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RFM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HST1_YEASTHST1physical
12612074
SUM1_YEASTSUM1physical
12612074
ORC2_YEASTORC2genetic
18990212
STE50_YEASTSTE50genetic
27708008
MMR1_YEASTMMR1genetic
27708008
ORC2_YEASTORC2genetic
27708008
RPN5_YEASTRPN5genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
SNU56_YEASTSNU56genetic
27708008
ACT_YEASTACT1genetic
27708008
ORC6_YEASTORC6genetic
27708008
MOB1_YEASTMOB1genetic
27708008
PSF2_YEASTPSF2genetic
27708008
ORC3_YEASTORC3genetic
27708008
MCM5_YEASTMCM5genetic
27708008
TAD3_YEASTTAD3genetic
27708008
NAB3_YEASTNAB3genetic
27708008
IPL1_YEASTIPL1genetic
27708008
SYH_YEASTHTS1genetic
27708008
ORC4_YEASTORC4genetic
27708008
LTE1_YEASTLTE1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
INO2_YEASTINO2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MDM35_YEASTMDM35genetic
27708008
SRL3_YEASTSRL3genetic
27708008
GTR1_YEASTGTR1genetic
27708008
MGR3_YEASTMGR3genetic
27708008
CRZ1_YEASTCRZ1genetic
27708008
RTG1_YEASTRTG1genetic
27708008
DBP1_YEASTDBP1genetic
27708008
YP098_YEASTYPR098Cgenetic
27708008
CTF4_YEASTCTF4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RFM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASSSPECTROMETRY.

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