| UniProt ID | HST1_YEAST | |
|---|---|---|
| UniProt AC | P53685 | |
| Protein Name | NAD-dependent protein deacetylase HST1 | |
| Gene Name | HST1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 503 | |
| Subcellular Localization | Nucleus . But not nucleolar, and cytoplasmic. | |
| Protein Description | NAD-dependent histone deacetylase involved in telomeric silencing. Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Restores silencing at HMR in SIR2 mutants when overexpressed. Required to repress middle sporulation genes during vegetative growth. Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. Regulates the gene expression of de novo NAD(+) biosynthesis genes.. | |
| Protein Sequence | MNILLMQRIVSFILVVSQGRYFHVGELTMTMLKRPQEEESDNNATKKLKTRLTYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNITSNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRLRLPNFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVTHAEFDLNLLGFCDDVASLVAKKCHWDIPHKKWQDLKKIDYNCTEIDKGTYKIKKQPRKKQQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Phosphorylation | KRPQEEESDNNATKK CCCCCCCCCCCCCHH | 49.25 | 28889911 | |
| 91 | Phosphorylation | LKDNDLKTFLEYFLP EECCCHHHHHHHHCC | 40.52 | 28889911 | |
| 95 | Phosphorylation | DLKTFLEYFLPVEVN CHHHHHHHHCCCCHH | 16.74 | 28889911 | |
| 103 | Phosphorylation | FLPVEVNSIYIYFMI HCCCCHHHHHHHHHH | 23.19 | 28889911 | |
| 105 | Phosphorylation | PVEVNSIYIYFMIKL CCCHHHHHHHHHHHH | 6.87 | 28889911 | |
| 107 | Phosphorylation | EVNSIYIYFMIKLLG CHHHHHHHHHHHHHC | 3.10 | 28889911 | |
| 137 | Phosphorylation | ITSNKERSSAELSSI CCCCCCCCHHHHHHH | 34.68 | 22369663 | |
| 138 | Phosphorylation | TSNKERSSAELSSIH CCCCCCCHHHHHHHH | 31.80 | 22369663 | |
| 142 | Phosphorylation | ERSSAELSSIHAKAE CCCHHHHHHHHHHCC | 20.82 | 21440633 | |
| 143 | Phosphorylation | RSSAELSSIHAKAED CCHHHHHHHHHHCCC | 30.90 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HST1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HST1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HST1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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