ORC4_YEAST - dbPTM
ORC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC4_YEAST
UniProt AC P54791
Protein Name Origin recognition complex subunit 4
Gene Name ORC4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 529
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication..
Protein Sequence MTISEARLSPQVNLLPIKRHSNEEVEETAAILKKRTIDNEKCKDSDPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMPQIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLSNNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGTMIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTISEARLS
------CCCCHHHCC		32.9622369663
4Phosphorylation----MTISEARLSPQ
----CCCCHHHCCCC		18.9422369663
9PhosphorylationTISEARLSPQVNLLP
CCCHHHCCCCCCEEE		14.0322369663
18UbiquitinationQVNLLPIKRHSNEEV
CCCEEEECCCCCHHH		41.9624961812
21PhosphorylationLLPIKRHSNEEVEET
EEEECCCCCHHHHHH		50.3919779198
262AcetylationNILEYLEKRVKSRFS
HHHHHHHHHHHHHHH		60.9524489116
262UbiquitinationNILEYLEKRVKSRFS
HHHHHHHHHHHHHHH		60.9524961812
293PhosphorylationDAVRNLLTVRSEISP
HHHHHHHHHHHHHHH		19.6221126336
299PhosphorylationLTVRSEISPWVSQWN
HHHHHHHHHHHHHHH		14.5227017623
308PhosphorylationWVSQWNETLEKELSD
HHHHHHHHHHHHHCC		36.6827017623
314PhosphorylationETLEKELSDPRSNLN
HHHHHHHCCCCHHHH		46.8127017623
424PhosphorylationKMIKAINSRIPTVAP
HHHHHHHHCCCCCCC		26.0228889911
428PhosphorylationAINSRIPTVAPTTNV
HHHHCCCCCCCCCCC		27.2528889911
432PhosphorylationRIPTVAPTTNVGTGQ
CCCCCCCCCCCCCCC		22.6728889911
433PhosphorylationIPTVAPTTNVGTGQS
CCCCCCCCCCCCCCC		27.1828889911
440PhosphorylationTNVGTGQSTFSIDNT
CCCCCCCCEEECCCH		32.5328889911
441PhosphorylationNVGTGQSTFSIDNTI
CCCCCCCEEECCCHH		17.3228889911
443PhosphorylationGTGQSTFSIDNTIKL
CCCCCEEECCCHHHH		29.1728889911
447PhosphorylationSTFSIDNTIKLWLKK
CEEECCCHHHHHHHH		18.7528889911
482PhosphorylationVGLRDNATAAFYASN
CCCCCCCHHEEEEEC		25.4427017623
486PhosphorylationDNATAAFYASNYQFQ
CCCHHEEEEECCEEE		12.3727017623
495PhosphorylationSNYQFQGTMIPFDLR
ECCEEECEEEECCHH		10.9227017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B2_YEASTHTB2physical
16554755
YRA1_YEASTYRA1physical
16554755
HAT2_YEASTHAT2physical
16554755
ORC5_YEASTORC5physical
17107343
ORC1_YEASTORC1physical
17880717
ORC2_YEASTORC2physical
17880717
ORC3_YEASTORC3physical
17880717
ORC4_YEASTORC4physical
17880717
ORC5_YEASTORC5physical
17880717
ORC6_YEASTORC6physical
17880717
HAT1_YEASTHAT1physical
17880717
HAT2_YEASTHAT2physical
17880717
ORC5_YEASTORC5physical
17825065
ORC1_YEASTORC1physical
17825065
ORC5_YEASTORC5physical
18647841
HSP7F_YEASTSSE1physical
19536198
ORC2_YEASTORC2physical
20732327
ORC1_YEASTORC1physical
22421151
ORC5_YEASTORC5physical
22421151
CDC6_YEASTCDC6physical
26456755
RMRP_YEASTSNM1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
MED7_YEASTMED7genetic
27708008
DYR_YEASTDFR1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
ITC1_YEASTITC1genetic
27708008
ENV10_YEASTENV10genetic
27708008
SIW14_YEASTSIW14genetic
27708008
RFA1_YEASTRFA1genetic
27708008
MCM2_YEASTMCM2genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
CDC27_YEASTCDC27genetic
27708008
ORC2_YEASTORC2genetic
27708008
RFC5_YEASTRFC5genetic
27708008
MCM7_YEASTMCM7genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC7_YEASTCDC7genetic
27708008
DPOD_YEASTPOL3genetic
27708008
DBF4_YEASTDBF4genetic
27708008
SECU_YEASTPDS1genetic
27708008
SPC19_YEASTSPC19genetic
27708008
TRS23_YEASTTRS23genetic
27708008
MOB2_YEASTMOB2genetic
27708008
CDC14_YEASTCDC14genetic
27708008
RNA15_YEASTRNA15genetic
27708008
HSF_YEASTHSF1genetic
27708008
SLD3_YEASTSLD3genetic
27708008
CDC20_YEASTCDC20genetic
27708008
OKP1_YEASTOKP1genetic
27708008
ORC6_YEASTORC6genetic
27708008
DNA2_YEASTDNA2genetic
27708008
CDC23_YEASTCDC23genetic
27708008
CTF8_YEASTCTF8genetic
27708008
MCM10_YEASTMCM10genetic
27708008
STS1_YEASTSTS1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
CDC6_YEASTCDC6genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
CDT1_YEASTTAH11genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RFC2_YEASTRFC2genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
CDC16_YEASTCDC16genetic
27708008
PRI2_YEASTPRI2genetic
27708008
CENPA_YEASTCSE4genetic
27708008
PRS7_YEASTRPT1genetic
27708008
ORC3_YEASTORC3genetic
27708008
CFT2_YEASTCFT2genetic
27708008
MCM5_YEASTMCM5genetic
27708008
ORC1_YEASTORC1genetic
27708008
POB3_YEASTPOB3genetic
27708008
PDS5_YEASTPDS5genetic
27708008
LCB1_YEASTLCB1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
APC5_YEASTAPC5genetic
27708008
DEP1_YEASTDEP1genetic
27708008
FUN30_YEASTFUN30genetic
27708008
HIR1_YEASTHIR1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
CSG2_YEASTCSG2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
HPC2_YEASTHPC2genetic
27708008
DCC1_YEASTDCC1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
PER1_YEASTPER1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
MAF1_YEASTMAF1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
NBP2_YEASTNBP2genetic
27708008
SAS4_YEASTSAS4genetic
27708008
UME6_YEASTUME6genetic
27708008
RAD9_YEASTRAD9genetic
27708008
RT103_YEASTRTT103genetic
27708008
SUM1_YEASTSUM1genetic
27708008
IPK1_YEASTIPK1genetic
27708008
MSN5_YEASTMSN5genetic
27708008
SPT2_YEASTSPT2genetic
27708008
CHD1_YEASTCHD1genetic
27708008
RAD24_YEASTRAD24genetic
27708008
FAB1_YEASTFAB1genetic
27708008
PUF4_YEASTPUF4genetic
27708008
CLG1_YEASTCLG1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
DBF2_YEASTDBF2genetic
27708008
SKN1_YEASTSKN1genetic
27708008
PBP1_YEASTPBP1genetic
27708008
BUB1_YEASTBUB1genetic
27708008
SMI1_YEASTSMI1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
NPR3_YEASTNPR3genetic
27708008
RRM3_YEASTRRM3genetic
27708008
SDS3_YEASTSDS3genetic
27708008
PTPA1_YEASTRRD1genetic
27708008
MPH1_YEASTMPH1genetic
27708008
ASF1_YEASTASF1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
YAK1_YEASTYAK1genetic
27708008
MNN11_YEASTMNN11genetic
27708008
SWE1_YEASTSWE1genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
HIR3_YEASTHIR3genetic
27708008
BUD2_YEASTBUD2genetic
27708008
FEN1_YEASTRAD27genetic
27708008
DBP7_YEASTDBP7genetic
27708008
RIC1_YEASTRIC1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
ACE2_YEASTACE2genetic
27708008
BUD6_YEASTBUD6genetic
27708008
VIP1_YEASTVIP1genetic
27708008
TDA5_YEASTTDA5genetic
27708008
SUB1_YEASTSUB1genetic
27708008
CSM3_YEASTCSM3genetic
27708008
CTF18_YEASTCTF18genetic
27708008
HSC82_YEASTHSC82genetic
27708008
SCS7_YEASTSCS7genetic
27708008
BUL1_YEASTBUL1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
BRE5_YEASTBRE5genetic
27708008
TLG2_YEASTTLG2genetic
27708008
HST3_YEASTHST3genetic
27708008
BUB3_YEASTBUB3genetic
27708008
STI1_YEASTSTI1genetic
27708008
HIR2_YEASTHIR2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
WHI5_YEASTWHI5genetic
27708008
ELG1_YEASTELG1genetic
27708008
LIS1_YEASTPAC1genetic
27708008
PALA_YEASTRIM20genetic
27708008
RFM1_YEASTRFM1genetic
27708008
RAD17_YEASTRAD17genetic
27708008
RTC6_YEASTRTC6genetic
27708008
DDC1_YEASTDDC1genetic
27708008
PUS1_YEASTPUS1genetic
27708008
ORC1_YEASTORC1physical
28191893
ORC2_YEASTORC2physical
28191893
CDC6_YEASTCDC6physical
28191893
GOGA2_HUMANGOLGA2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-440, AND MASSSPECTROMETRY.

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